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The map label for this gene is fabF [H]

Identifier: 209548662

GI number: 209548662

Start: 1076469

End: 1077731

Strand: Direct

Name: fabF [H]

Synonym: Rleg2_1059

Alternate gene names: 209548662

Gene position: 1076469-1077731 (Clockwise)

Preceding gene: 209548661

Following gene: 209548663

Centisome position: 23.72

GC content: 65.56

Gene sequence:

>1263_bases
ATGAGACGTGTCGTCATAACAGGTACCGGCATGGTATCACCCTTGGGATGCGGAACCGAGGTGACGTGGTCCCGGCTGCT
TGCCGGTCAGAACGGCGCCCGCCTCGTCACCGAATTCGAGGTCGACGACCTTCCCGCCAAGATCGCCTGCCGTATTCCCA
TCGGCGACGGCACCGACGGCACCTTCAATGTCGATCAGTGGATGGAGCCGAAGGAGCAGCGCAAGGTCGACCCCTTCATC
ATCTACGGCATGGCCGCCGCCGATATGGCGCTTGCCGATGCCGGCTGGCATCCCGAGACCGATGAGGACCAGATCGCCAC
CGGCGTGCTGATCGGCTCCGGCATCGGCGGCATCGAAGGCATCGTCGAGGCAGGTTACACCCTGCGCGACAAGGGCCCGC
GCCGCATCTCCCCCTTCTTCATTCCCGGCCGCCTGATCAACCTCGTCTCTGGCCAGGTCTCGATCCGCCACAAGCTGCGC
GGACCCAATCACTCGGTCGTCACCGCCTGCTCGACAGGCGCGCATGCGATCGGCGATGCCGCGCGGCTGATTGCGCTTGG
CGATGCCGACGTCATGGTCGCCGGCGGCACGGAATCCCCCGTCAGCCGCATTTCGCTCGCCGGCTTTGCCGCCTGCAAGG
CACTGTCGACCCAGCACAACGATGACCCGCAGAAGGCCTCGCGCCCCTATGACCGCGACCGTGACGGCTTCGTCATGGGT
GAGGGCGCCGGCATCGTCGTGCTCGAGGAACTGGAACACGCCAAGGCGCGCGGCGCCAGGATCTACGCCGAAATCGTCGG
CTACGGCCTGTCGGGCGACGCCTATCACATCACCGCGCCGTCCGAAGACGGCGAGGGCGCCGGCCGTTGCATGGCGATGG
CGCTGAAGCGCGCCGGACTGACGCCGGCCGATATCGACTACATCAACGCCCACGGCACTTCGACCATGGCCGACACGATC
GAGCTCGGCGCCGTCGAGCGGCTGGTCGGCAATGCGGCGTCGAAGATCTCCATGTCATCGACCAAATCGGCAACAGGACA
CCTTCTTGGTGCTGCCGGCGCGATCGAGGCGATCTTCACCACGCTCGCCATCCGTGACAATGTCGCGCCGCCGACGCTCA
ACCTCGACAATCCCGAACGCGAGACGGCGATCGATCTTGTTCCGCACAAGGCGCGCGAGCGAGAAATCAATGTGGCGCTG
TCCAACTCGTTCGGATTCGGCGGCACGAACGCGTCGCTCGTCCTGCGCCGTTACGCGCAATAG

Upstream 100 bases:

>100_bases
GGCCTGATTCTGTAATTTTGAGAAAGGGCGGGCCTGGAGTCCGCCCTTTTCTTTTCGGCATATTTCTCCATAGAACATAA
CAGACGGGGGAAAGCACGCG

Downstream 100 bases:

>100_bases
AGTCTCGTACGCGCGGTGTAATGGGTGTCCCTTACACCGCAAACCGGCCGGTCCTCTGCATTGCGGAGCAGCGTGTGCGG
GAGCATAACGGCCGGCAGCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVITGTGMVSPLGCGTEVTWSRLLAGQNGARLVTEFEVDDLPAKIACRIPIGDGTDGTFNVDQWMEPKEQRKVDPFI
IYGMAAADMALADAGWHPETDEDQIATGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLVSGQVSIRHKLR
GPNHSVVTACSTGAHAIGDAARLIALGDADVMVAGGTESPVSRISLAGFAACKALSTQHNDDPQKASRPYDRDRDGFVMG
EGAGIVVLEELEHAKARGARIYAEIVGYGLSGDAYHITAPSEDGEGAGRCMAMALKRAGLTPADIDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSATGHLLGAAGAIEAIFTTLAIRDNVAPPTLNLDNPERETAIDLVPHKAREREINVAL
SNSFGFGGTNASLVLRRYAQ

Sequences:

>Translated_420_residues
MRRVVITGTGMVSPLGCGTEVTWSRLLAGQNGARLVTEFEVDDLPAKIACRIPIGDGTDGTFNVDQWMEPKEQRKVDPFI
IYGMAAADMALADAGWHPETDEDQIATGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLVSGQVSIRHKLR
GPNHSVVTACSTGAHAIGDAARLIALGDADVMVAGGTESPVSRISLAGFAACKALSTQHNDDPQKASRPYDRDRDGFVMG
EGAGIVVLEELEHAKARGARIYAEIVGYGLSGDAYHITAPSEDGEGAGRCMAMALKRAGLTPADIDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSATGHLLGAAGAIEAIFTTLAIRDNVAPPTLNLDNPERETAIDLVPHKAREREINVAL
SNSFGFGGTNASLVLRRYAQ
>Mature_420_residues
MRRVVITGTGMVSPLGCGTEVTWSRLLAGQNGARLVTEFEVDDLPAKIACRIPIGDGTDGTFNVDQWMEPKEQRKVDPFI
IYGMAAADMALADAGWHPETDEDQIATGVLIGSGIGGIEGIVEAGYTLRDKGPRRISPFFIPGRLINLVSGQVSIRHKLR
GPNHSVVTACSTGAHAIGDAARLIALGDADVMVAGGTESPVSRISLAGFAACKALSTQHNDDPQKASRPYDRDRDGFVMG
EGAGIVVLEELEHAKARGARIYAEIVGYGLSGDAYHITAPSEDGEGAGRCMAMALKRAGLTPADIDYINAHGTSTMADTI
ELGAVERLVGNAASKISMSSTKSATGHLLGAAGAIEAIFTTLAIRDNVAPPTLNLDNPERETAIDLVPHKAREREINVAL
SNSFGFGGTNASLVLRRYAQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=53.3492822966507, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=44.559585492228, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI41872631, Length=365, Percent_Identity=26.027397260274, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=52.6315789473684, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=39.7163120567376, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=39.1509433962264, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=43.609022556391, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.7441860465116, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=323, Percent_Identity=25.3869969040248, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=42.0581655480984, Blast_Score=306, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=46.2085308056872, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI19920632, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221330659, Length=369, Percent_Identity=26.0162601626016, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581345, Length=374, Percent_Identity=24.0641711229947, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44201; Mature: 44201

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGTGMVSPLGCGTEVTWSRLLAGQNGARLVTEFEVDDLPAKIACRIPIGDGTDG
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCC
TFNVDQWMEPKEQRKVDPFIIYGMAAADMALADAGWHPETDEDQIATGVLIGSGIGGIEG
EEEHHHHCCCHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCHHHH
IVEAGYTLRDKGPRRISPFFIPGRLINLVSGQVSIRHKLRGPNHSVVTACSTGAHAIGDA
HHHCCCEEECCCCCCCCCEEECHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCHHHCCC
ARLIALGDADVMVAGGTESPVSRISLAGFAACKALSTQHNDDPQKASRPYDRDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEELEHAKARGARIYAEIVGYGLSGDAYHITAPSEDGEGAGRCMAMALKRAGL
CCCCEEEEECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
TPADIDYINAHGTSTMADTIELGAVERLVGNAASKISMSSTKSATGHLLGAAGAIEAIFT
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCCEEEHHHHHHHHHH
TLAIRDNVAPPTLNLDNPERETAIDLVPHKAREREINVALSNSFGFGGTNASLVLRRYAQ
HHHHCCCCCCCCCCCCCCCHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRRVVITGTGMVSPLGCGTEVTWSRLLAGQNGARLVTEFEVDDLPAKIACRIPIGDGTDG
CCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCC
TFNVDQWMEPKEQRKVDPFIIYGMAAADMALADAGWHPETDEDQIATGVLIGSGIGGIEG
EEEHHHHCCCHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCHHHH
IVEAGYTLRDKGPRRISPFFIPGRLINLVSGQVSIRHKLRGPNHSVVTACSTGAHAIGDA
HHHCCCEEECCCCCCCCCEEECHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCHHHCCC
ARLIALGDADVMVAGGTESPVSRISLAGFAACKALSTQHNDDPQKASRPYDRDRDGFVMG
EEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEELEHAKARGARIYAEIVGYGLSGDAYHITAPSEDGEGAGRCMAMALKRAGL
CCCCEEEEECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
TPADIDYINAHGTSTMADTIELGAVERLVGNAASKISMSSTKSATGHLLGAAGAIEAIFT
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCCEEEHHHHHHHHHH
TLAIRDNVAPPTLNLDNPERETAIDLVPHKAREREINVALSNSFGFGGTNASLVLRRYAQ
HHHHCCCCCCCCCCCCCCCHHHEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]