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The map label for this gene is pip [H]

Identifier: 209548636

GI number: 209548636

Start: 1053366

End: 1054328

Strand: Reverse

Name: pip [H]

Synonym: Rleg2_1033

Alternate gene names: 209548636

Gene position: 1054328-1053366 (Counterclockwise)

Preceding gene: 209548637

Following gene: 209548635

Centisome position: 23.23

GC content: 62.41

Gene sequence:

>963_bases
ATGACCGAGAGACTGCGCACGCTCTATCCTGAAATCGAAGCCTATGCTTCAGGCCATCTCGATGTCGGCGATGGTCATGT
GATCTATTGGGAGCGCTCGGGAACGCCTGGCGCCAAGCCCGCCGTTTTCCTGCATGGCGGCCCCGGTGGCGGCTTCTCGC
CCGTCCATCGCCGGCTTTTCGATGCCGCCCTCTACGACGTCATGCTGTTCGACCAGCGCGGTTGCGGCAGGTCGACGCCG
CATGCGGAACTGAATGCCAATACGACCTGGCACCTCGTCGCCGATATCGAGCGGCTGCGGGAAATGGCCGGCGTCGACAG
CTGGCAGGTGTTCGGCGGCTCCTGGGGTTCGACGCTGGCGCTCGCCTATGCCGAGGCGCATCCGGAGCGCGTCTCCGAAC
TCATTCTGCGCGGCATCTATACGCTGACCAAGGCCGAGCTCGACTGGTACTATCAGTTCGGCGTCTCGGAAATGTTCCCG
GACAAATGGGAGCGCTTCATCGCTCCCATTCCGCCGGAGGAGCGGCATGAGATGATGCATGCCTATCATCGCCGCCTGAC
ACATGAGGATCGGTCCGTGCGCCTTGCCGCCGCGCAGACATGGAGCATCTGGGAAGGCGAAACGATCACGCTGCTGCCTG
AGCCTTCGACCAGCGGCAAGTTCGAAGAACCGGAATTCGCCTATGCATTTGCGCGCATCGAGAATCATTTCTTCGTCAAT
GCCGGCTGGATGGACGAGGGACAGCTGATCCGCGATGCCGGCCGGCTGAAGGATATTCCCGGCGTCATCGTACATGGCCG
CTACGACATGCCCTGCCCGGCCAAATACGCCTGGCTGCTGCACAAGGCCTGGCCGAAGGCGGAATTTCACCTGATCGAGG
GTGCCGGCCATGCCTATTCGGAGCCCGGCATTCTCGACCGGCTGATCCGGGCGACGGACAAGTTTGCCGGGAAACCCGAC
TGA

Upstream 100 bases:

>100_bases
TGCTGAAGGATCAGGATTTCTACGCACGGCAGGAAGCGATCATCTCCTTCCAGCATCCCGATCACGATACCGAAGTCTGG
CCCGCGAAAGGCGTGAAAAT

Downstream 100 bases:

>100_bases
CTGTCCTGGCTAAGGCGCCCCTCACCCTAGCCCTCTCCCCGCGCGCGGGGAGAGGGGACGTGCCTTGCGATACGGTGCGG
CATCCGCACCACACAACACC

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTERLRTLYPEIEAYASGHLDVGDGHVIYWERSGTPGAKPAVFLHGGPGGGFSPVHRRLFDAALYDVMLFDQRGCGRSTP
HAELNANTTWHLVADIERLREMAGVDSWQVFGGSWGSTLALAYAEAHPERVSELILRGIYTLTKAELDWYYQFGVSEMFP
DKWERFIAPIPPEERHEMMHAYHRRLTHEDRSVRLAAAQTWSIWEGETITLLPEPSTSGKFEEPEFAYAFARIENHFFVN
AGWMDEGQLIRDAGRLKDIPGVIVHGRYDMPCPAKYAWLLHKAWPKAEFHLIEGAGHAYSEPGILDRLIRATDKFAGKPD

Sequences:

>Translated_320_residues
MTERLRTLYPEIEAYASGHLDVGDGHVIYWERSGTPGAKPAVFLHGGPGGGFSPVHRRLFDAALYDVMLFDQRGCGRSTP
HAELNANTTWHLVADIERLREMAGVDSWQVFGGSWGSTLALAYAEAHPERVSELILRGIYTLTKAELDWYYQFGVSEMFP
DKWERFIAPIPPEERHEMMHAYHRRLTHEDRSVRLAAAQTWSIWEGETITLLPEPSTSGKFEEPEFAYAFARIENHFFVN
AGWMDEGQLIRDAGRLKDIPGVIVHGRYDMPCPAKYAWLLHKAWPKAEFHLIEGAGHAYSEPGILDRLIRATDKFAGKPD
>Mature_319_residues
TERLRTLYPEIEAYASGHLDVGDGHVIYWERSGTPGAKPAVFLHGGPGGGFSPVHRRLFDAALYDVMLFDQRGCGRSTPH
AELNANTTWHLVADIERLREMAGVDSWQVFGGSWGSTLALAYAEAHPERVSELILRGIYTLTKAELDWYYQFGVSEMFPD
KWERFIAPIPPEERHEMMHAYHRRLTHEDRSVRLAAAQTWSIWEGETITLLPEPSTSGKFEEPEFAYAFARIENHFFVNA
GWMDEGQLIRDAGRLKDIPGVIVHGRYDMPCPAKYAWLLHKAWPKAEFHLIEGAGHAYSEPGILDRLIRATDKFAGKPD

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36320; Mature: 36189

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERLRTLYPEIEAYASGHLDVGDGHVIYWERSGTPGAKPAVFLHGGPGGGFSPVHRRLF
CCCHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHH
DAALYDVMLFDQRGCGRSTPHAELNANTTWHLVADIERLREMAGVDSWQVFGGSWGSTLA
HHHHHHHHEECCCCCCCCCCCCEECCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCEE
LAYAEAHPERVSELILRGIYTLTKAELDWYYQFGVSEMFPDKWERFIAPIPPEERHEMMH
EEHHHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHCCHHHHHHHCCCCCCHHHHHHHH
AYHRRLTHEDRSVRLAAAQTWSIWEGETITLLPEPSTSGKFEEPEFAYAFARIENHFFVN
HHHHHHCCCCCCEEEEEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHEECCCEEEEE
AGWMDEGQLIRDAGRLKDIPGVIVHGRYDMPCPAKYAWLLHKAWPKAEFHLIEGAGHAYS
CCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCC
EPGILDRLIRATDKFAGKPD
CCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TERLRTLYPEIEAYASGHLDVGDGHVIYWERSGTPGAKPAVFLHGGPGGGFSPVHRRLF
CCHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHH
DAALYDVMLFDQRGCGRSTPHAELNANTTWHLVADIERLREMAGVDSWQVFGGSWGSTLA
HHHHHHHHEECCCCCCCCCCCCEECCCCEEEHHHHHHHHHHHHCCCCEEEECCCCCCCEE
LAYAEAHPERVSELILRGIYTLTKAELDWYYQFGVSEMFPDKWERFIAPIPPEERHEMMH
EEHHHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHCCHHHHHHHCCCCCCHHHHHHHH
AYHRRLTHEDRSVRLAAAQTWSIWEGETITLLPEPSTSGKFEEPEFAYAFARIENHFFVN
HHHHHHCCCCCCEEEEEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHEECCCEEEEE
AGWMDEGQLIRDAGRLKDIPGVIVHGRYDMPCPAKYAWLLHKAWPKAEFHLIEGAGHAYS
CCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCC
EPGILDRLIRATDKFAGKPD
CCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]