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The map label for this gene is rsh [H]

Identifier: 209548596

GI number: 209548596

Start: 1015988

End: 1018222

Strand: Direct

Name: rsh [H]

Synonym: Rleg2_0993

Alternate gene names: 209548596

Gene position: 1015988-1018222 (Clockwise)

Preceding gene: 209548595

Following gene: 209548597

Centisome position: 22.39

GC content: 61.83

Gene sequence:

>2235_bases
ATGATGCGGCAGTACGAGCTCGTGGAGCGGGTTCAGCAATACAAGCCCGATGCCAATGAAGCACTGCTGAACAAAGCCTA
TGTCTACGCCATGCAGAAACATGGCCAGCAGAAGCGCGCGAGCGGCGATCCCTATATCTCCCATCCGCTCGAAGTCGCAG
CCATCCTCACGGACATGCATCTCGATGAATCGACGATCGCGGTCGCGCTGCTGCACGATACGATCGAGGATACGACGGCA
ACGCGCGCCGAGATCGACGAACTCTTCGGCGAGGATATCGGCCGCCTGGTCGAGGGCCTGACCAAGATCAAGAAGCTCGA
TCTCGTCACCAAGAAGGCCAAGCAGGCGGAAAATCTGCGCAAGCTGCTGCTCGCCATTTCCGACGATGTGCGCGTGCTGC
TGGTCAAGCTTGCCGATCGCCTGCACAATATGCGCACCCTCGATCATATGTCGGCCGACAAGCGTGCCCGCATCTCCGAG
GAGACGATGGAAATCTATGCGCCGCTCGCCGGCCGCATGGGCATGCAGGACATGCGCGAAGAGCTGGAAGAGCTTTCCTT
CCGCCATATGAACCCGGAAGCCTACGAGACCGTCACCAAAAGGCTGGAAGAGCTTTCCAAGCGCAATGAAGGCATCGTCA
AGAAGATCGAGGCGGAACTGCGCGACTTGCTGGTCGCAAGCGGCCTGACGAGCGCCTATGTCAAGGGCCGGCAGAAGAAG
CCCTATTCGGTCTTCCGCAAGATGCAGTCGAAGTCGCTTTCCTTCGAGCAGCTTTCCGATGTCTACGGTTTTCGGCTCAT
CGTCGAAGATATCCCGTCCTGCTACCGGGCGCTCGGCATTGTCCACACCCGCTGGCGCGTCGTGCCCGGCCGCTTCAAGG
ATTATATCTCGACGCCGAAGCAGAACGATTACCGTTCCCTGCACACCACCATCGTCGGTCCATCCAGCCAGCGCATCGAA
CTGCAGATCCGCACCAAGCGCATGCACGAAATCGCCGAATTCGGCATCGCCGCCCACACGCTCTATAAGGACGGCGCCAC
CAATGCCGACGGCGACATTCTCTCCCGTGAATCCAACGCTTATTCCTGGCTGCGCCATACGATCGAGGCGCTGGCCGAGG
GCGACAGCCCGGAAGAATTCCTCGAGCACACCAAGCTCGAACTCTTCCAGGACCAGGTCTTCTGCTTCACGCCGAAAGGC
AAGCTGATTGCTCTGCCGCGTGGCGCCACGCCGATCGATTTCGCCTATGCGGTGCACACCAATATCGGCGATACCACGGT
GGGCGCCAAGATCAACGGCCGCATCATGCCGCTGGTGACGCGGCTTGCCAACGGCGACGAGGTCGAGATCATCCGCTCCG
GCGTGCAGGTTCCGCCGGCCGCCTGGGAGGAGATCGTCGTCACCGGCAAGGCGCGCGCCGCCATCCGCCGCGCCACCCGC
ATGGCGATCCGCAAGCAATATGCCGGCCTCGGCCACCGCATTCTCGAGCGCACCTTCGACAGGGCCGGCAAGATCTTTTC
ACGCGAGGCGATGAAGCCGGCGCTGCATCGTCTCGGCCAGAAGGATGTCGAGGATGCGATCGCCGCCGTCGGCCGCGGCG
AGATGTCCTCGCTCGATGTGCTGCGCGCCGTCTATCCCGACCATCAGGATGAGCGCGTCACGGTGAAACCCTCGGGCGAC
GACGGCTGGTTCAACGTCCGCAGCGCGGCCGGCATGATCTTCAAGATCCCCGGCAAAACCAAGCCCGGGCTCGACGGCGG
CCATTCGGACATCGACACCGACGCCGATATCGGGCCGATCCGCGGCCTGTCCGGCAATGTCGACGTCAAGTTCGCGTCGA
CAGGCGCGGTGCCCGGCGATCGCATCGTCGGCATCATGGACCAGAGCAAGGGCATCACCATCTATCCGATCCAGTCGCCG
AGCCTGCAGCGCTTCGACGATCAGCCCGACCGTTGGATCGACGTCCGCTGGGATCTCGACGAAGCCAACAAGTCGCGTTT
CATGGCGCGCATCATGGTCAACGGGTTGAATGAGCCCGGCACACTGGCCAAGGTCGCCCAGACGGTTGCCGGCCTCGACG
TCAATATCCGTCTGCTGAATACGGTGCGGGTCGCGGCGGATTTCACCGAAATGATGCTCGAGGTCGAGGTCTGGGACCTG
CGTCAACTCAATCAGCTGCTCGCCCAGATGAAGGAACTGGATTGCATCGCCACGGTCCGGCGGCTCTATGAGTAA

Upstream 100 bases:

>100_bases
AATCGTCAATCTTGCGCCTTTATTGCTTAGGCATATTATTGCCCATGTGTGCGCCAATCGTTGATTGGCGCGCTTTTATT
TTTACCGGAGTGGCTTTGGA

Downstream 100 bases:

>100_bases
AGCTTTTGTTAAGCCCTGAGGAATCTAAGCGCGCAATTGCACATTTTATGATCGTTCTGTGGTGAGGGTGGTACGCTAAA
AAGGCAAGCAATGCATTGTA

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MMRQYELVERVQQYKPDANEALLNKAYVYAMQKHGQQKRASGDPYISHPLEVAAILTDMHLDESTIAVALLHDTIEDTTA
TRAEIDELFGEDIGRLVEGLTKIKKLDLVTKKAKQAENLRKLLLAISDDVRVLLVKLADRLHNMRTLDHMSADKRARISE
ETMEIYAPLAGRMGMQDMREELEELSFRHMNPEAYETVTKRLEELSKRNEGIVKKIEAELRDLLVASGLTSAYVKGRQKK
PYSVFRKMQSKSLSFEQLSDVYGFRLIVEDIPSCYRALGIVHTRWRVVPGRFKDYISTPKQNDYRSLHTTIVGPSSQRIE
LQIRTKRMHEIAEFGIAAHTLYKDGATNADGDILSRESNAYSWLRHTIEALAEGDSPEEFLEHTKLELFQDQVFCFTPKG
KLIALPRGATPIDFAYAVHTNIGDTTVGAKINGRIMPLVTRLANGDEVEIIRSGVQVPPAAWEEIVVTGKARAAIRRATR
MAIRKQYAGLGHRILERTFDRAGKIFSREAMKPALHRLGQKDVEDAIAAVGRGEMSSLDVLRAVYPDHQDERVTVKPSGD
DGWFNVRSAAGMIFKIPGKTKPGLDGGHSDIDTDADIGPIRGLSGNVDVKFASTGAVPGDRIVGIMDQSKGITIYPIQSP
SLQRFDDQPDRWIDVRWDLDEANKSRFMARIMVNGLNEPGTLAKVAQTVAGLDVNIRLLNTVRVAADFTEMMLEVEVWDL
RQLNQLLAQMKELDCIATVRRLYE

Sequences:

>Translated_744_residues
MMRQYELVERVQQYKPDANEALLNKAYVYAMQKHGQQKRASGDPYISHPLEVAAILTDMHLDESTIAVALLHDTIEDTTA
TRAEIDELFGEDIGRLVEGLTKIKKLDLVTKKAKQAENLRKLLLAISDDVRVLLVKLADRLHNMRTLDHMSADKRARISE
ETMEIYAPLAGRMGMQDMREELEELSFRHMNPEAYETVTKRLEELSKRNEGIVKKIEAELRDLLVASGLTSAYVKGRQKK
PYSVFRKMQSKSLSFEQLSDVYGFRLIVEDIPSCYRALGIVHTRWRVVPGRFKDYISTPKQNDYRSLHTTIVGPSSQRIE
LQIRTKRMHEIAEFGIAAHTLYKDGATNADGDILSRESNAYSWLRHTIEALAEGDSPEEFLEHTKLELFQDQVFCFTPKG
KLIALPRGATPIDFAYAVHTNIGDTTVGAKINGRIMPLVTRLANGDEVEIIRSGVQVPPAAWEEIVVTGKARAAIRRATR
MAIRKQYAGLGHRILERTFDRAGKIFSREAMKPALHRLGQKDVEDAIAAVGRGEMSSLDVLRAVYPDHQDERVTVKPSGD
DGWFNVRSAAGMIFKIPGKTKPGLDGGHSDIDTDADIGPIRGLSGNVDVKFASTGAVPGDRIVGIMDQSKGITIYPIQSP
SLQRFDDQPDRWIDVRWDLDEANKSRFMARIMVNGLNEPGTLAKVAQTVAGLDVNIRLLNTVRVAADFTEMMLEVEVWDL
RQLNQLLAQMKELDCIATVRRLYE
>Mature_744_residues
MMRQYELVERVQQYKPDANEALLNKAYVYAMQKHGQQKRASGDPYISHPLEVAAILTDMHLDESTIAVALLHDTIEDTTA
TRAEIDELFGEDIGRLVEGLTKIKKLDLVTKKAKQAENLRKLLLAISDDVRVLLVKLADRLHNMRTLDHMSADKRARISE
ETMEIYAPLAGRMGMQDMREELEELSFRHMNPEAYETVTKRLEELSKRNEGIVKKIEAELRDLLVASGLTSAYVKGRQKK
PYSVFRKMQSKSLSFEQLSDVYGFRLIVEDIPSCYRALGIVHTRWRVVPGRFKDYISTPKQNDYRSLHTTIVGPSSQRIE
LQIRTKRMHEIAEFGIAAHTLYKDGATNADGDILSRESNAYSWLRHTIEALAEGDSPEEFLEHTKLELFQDQVFCFTPKG
KLIALPRGATPIDFAYAVHTNIGDTTVGAKINGRIMPLVTRLANGDEVEIIRSGVQVPPAAWEEIVVTGKARAAIRRATR
MAIRKQYAGLGHRILERTFDRAGKIFSREAMKPALHRLGQKDVEDAIAAVGRGEMSSLDVLRAVYPDHQDERVTVKPSGD
DGWFNVRSAAGMIFKIPGKTKPGLDGGHSDIDTDADIGPIRGLSGNVDVKFASTGAVPGDRIVGIMDQSKGITIYPIQSP
SLQRFDDQPDRWIDVRWDLDEANKSRFMARIMVNGLNEPGTLAKVAQTVAGLDVNIRLLNTVRVAADFTEMMLEVEVWDL
RQLNQLLAQMKELDCIATVRRLYE

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=137, Percent_Identity=40.1459854014599, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1790082, Length=699, Percent_Identity=37.6251788268956, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789147, Length=740, Percent_Identity=30.1351351351351, Blast_Score=344, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=38.0597014925373, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650996, Length=123, Percent_Identity=39.0243902439024, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83674; Mature: 83674

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVQQYKPDANEALLNKAYVYAMQKHGQQKRASGDPYISHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHC
LDESTIAVALLHDTIEDTTATRAEIDELFGEDIGRLVEGLTKIKKLDLVTKKAKQAENLR
CCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISDDVRVLLVKLADRLHNMRTLDHMSADKRARISEETMEIYAPLAGRMGMQDMRE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELSFRHMNPEAYETVTKRLEELSKRNEGIVKKIEAELRDLLVASGLTSAYVKGRQKK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
PYSVFRKMQSKSLSFEQLSDVYGFRLIVEDIPSCYRALGIVHTRWRVVPGRFKDYISTPK
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCC
QNDYRSLHTTIVGPSSQRIELQIRTKRMHEIAEFGIAAHTLYKDGATNADGDILSRESNA
CCCHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
YSWLRHTIEALAEGDSPEEFLEHTKLELFQDQVFCFTPKGKLIALPRGATPIDFAYAVHT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEEC
NIGDTTVGAKINGRIMPLVTRLANGDEVEIIRSGVQVPPAAWEEIVVTGKARAAIRRATR
CCCCCEECCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHEEEECHHHHHHHHHHH
MAIRKQYAGLGHRILERTFDRAGKIFSREAMKPALHRLGQKDVEDAIAAVGRGEMSSLDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHH
LRAVYPDHQDERVTVKPSGDDGWFNVRSAAGMIFKIPGKTKPGLDGGHSDIDTDADIGPI
HHHHCCCCCCCEEEEEECCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
RGLSGNVDVKFASTGAVPGDRIVGIMDQSKGITIYPIQSPSLQRFDDQPDRWIDVRWDLD
CCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHCCCCCCCEEEEEECCC
EANKSRFMARIMVNGLNEPGTLAKVAQTVAGLDVNIRLLNTVRVAADFTEMMLEVEVWDL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
RQLNQLLAQMKELDCIATVRRLYE
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMRQYELVERVQQYKPDANEALLNKAYVYAMQKHGQQKRASGDPYISHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHC
LDESTIAVALLHDTIEDTTATRAEIDELFGEDIGRLVEGLTKIKKLDLVTKKAKQAENLR
CCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISDDVRVLLVKLADRLHNMRTLDHMSADKRARISEETMEIYAPLAGRMGMQDMRE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELSFRHMNPEAYETVTKRLEELSKRNEGIVKKIEAELRDLLVASGLTSAYVKGRQKK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
PYSVFRKMQSKSLSFEQLSDVYGFRLIVEDIPSCYRALGIVHTRWRVVPGRFKDYISTPK
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCC
QNDYRSLHTTIVGPSSQRIELQIRTKRMHEIAEFGIAAHTLYKDGATNADGDILSRESNA
CCCHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
YSWLRHTIEALAEGDSPEEFLEHTKLELFQDQVFCFTPKGKLIALPRGATPIDFAYAVHT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEEC
NIGDTTVGAKINGRIMPLVTRLANGDEVEIIRSGVQVPPAAWEEIVVTGKARAAIRRATR
CCCCCEECCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHEEEECHHHHHHHHHHH
MAIRKQYAGLGHRILERTFDRAGKIFSREAMKPALHRLGQKDVEDAIAAVGRGEMSSLDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHH
LRAVYPDHQDERVTVKPSGDDGWFNVRSAAGMIFKIPGKTKPGLDGGHSDIDTDADIGPI
HHHHCCCCCCCEEEEEECCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCC
RGLSGNVDVKFASTGAVPGDRIVGIMDQSKGITIYPIQSPSLQRFDDQPDRWIDVRWDLD
CCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHCCCCCCCEEEEEECCC
EANKSRFMARIMVNGLNEPGTLAKVAQTVAGLDVNIRLLNTVRVAADFTEMMLEVEVWDL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
RQLNQLLAQMKELDCIATVRRLYE
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA