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The map label for this gene is qor [C]

Identifier: 209548550

GI number: 209548550

Start: 970359

End: 971372

Strand: Reverse

Name: qor [C]

Synonym: Rleg2_0947

Alternate gene names: 209548550

Gene position: 971372-970359 (Counterclockwise)

Preceding gene: 209548552

Following gene: 209548549

Centisome position: 21.41

GC content: 63.61

Gene sequence:

>1014_bases
ATGCGCGCCGTTGCCTACAATAGCCCACAACCCATTACCGCCGAGACCTCGCTGATCGATATCGAGCTGCCGATGCCGGA
AGCCCGAGGCCACGACCTGCTGGTCGAGATCAAGGCCGTTTCCGTCAATCCAGCCGATGTCAAAATCCGCGCTCATGTGG
CGCCGCCCACGGACGAGCCGAGGGTGCTGGGCTGGGATGCCGCCGGCATCGTCAAGGCCGTCGGCGCCGACGTCACCCTG
TTCAAGCCCGGCGACCAGGTGTTCTATTCGGGCGCCCTCGCCCGCTCCGGCACCAATGCCGAATTCCATCTCGTCGACGA
GCGCATCGTCGGCGCCAAGCCGAAGAGCCTCGATTTCGCCGCTGCTGCAGCGCTGCCGCTGACCACGATCACCGCCTATG
AGGCTCTGTTCGATCGGCTGAAGGTGCAGGATCCGGTTTCGGGTGCGGCGCGCTCCATCCTCATCATCGGCGGCGCTGGC
GGCGTCGGCTCGATCGCCATCCAGATCGCGCGGGTGCTGACCGATCTCACCGTCATTGCCACGGCGTCGCGGCGTGAAAC
GCAGGACTGGGTGAAGGATCTCGGCGCCCACCACGTCATCGACCATTCCAGCCCGATCGCGCCGCAGGTGGCAGCGCTCG
GCATCGGCGCCCCAGGCTTCATCTTCTCGACGACGAACACCGACCTCCATATCGGCGACATCGTCGAAGTCATCGCGCCG
CAGGGCCGCTTCGCGTTGATCGACAATCCGAAGACCCTCGATGTCGTGCCCTTCATGCGCAAGAGCGCCTCTATCCACTG
GGAGCTGATGTTTACCCGTCCGCTCTTCGAAACGCCCGACATGATCGAGCAGCACAGGCTGTTGAACAGGATTTCCGAGC
TCGTCGACGCCGGCAAAATCCGCACGACACTTTCCGAAACCATCGGCCCGATCAATGCGGCAAACCTGAAGAAAGCGCAT
GCGATGGTTGAAACGGGCCGGATGAAGGGCAAGGCTGTGCTTGCCGGGTTCTGA

Upstream 100 bases:

>100_bases
ACAGTATCCTTTTTGGTACTATGTACAGAATTTGTGCATTCTTGCGCTGTTTCATCATAGTGCGCATCTAGCCTCCGTGC
AAAGAACACAGGAGTTTGCC

Downstream 100 bases:

>100_bases
GACCCGGTCGCCCGTGCAAATACCTCTCCTGGAATGTCGCATCGCGAGGTGCGACATTCTGGCGTTAAGCATTTCTCCCG
CTTGACTTATTCCGCGTTCG

Product: zinc-binding alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRAVAYNSPQPITAETSLIDIELPMPEARGHDLLVEIKAVSVNPADVKIRAHVAPPTDEPRVLGWDAAGIVKAVGADVTL
FKPGDQVFYSGALARSGTNAEFHLVDERIVGAKPKSLDFAAAAALPLTTITAYEALFDRLKVQDPVSGAARSILIIGGAG
GVGSIAIQIARVLTDLTVIATASRRETQDWVKDLGAHHVIDHSSPIAPQVAALGIGAPGFIFSTTNTDLHIGDIVEVIAP
QGRFALIDNPKTLDVVPFMRKSASIHWELMFTRPLFETPDMIEQHRLLNRISELVDAGKIRTTLSETIGPINAANLKKAH
AMVETGRMKGKAVLAGF

Sequences:

>Translated_337_residues
MRAVAYNSPQPITAETSLIDIELPMPEARGHDLLVEIKAVSVNPADVKIRAHVAPPTDEPRVLGWDAAGIVKAVGADVTL
FKPGDQVFYSGALARSGTNAEFHLVDERIVGAKPKSLDFAAAAALPLTTITAYEALFDRLKVQDPVSGAARSILIIGGAG
GVGSIAIQIARVLTDLTVIATASRRETQDWVKDLGAHHVIDHSSPIAPQVAALGIGAPGFIFSTTNTDLHIGDIVEVIAP
QGRFALIDNPKTLDVVPFMRKSASIHWELMFTRPLFETPDMIEQHRLLNRISELVDAGKIRTTLSETIGPINAANLKKAH
AMVETGRMKGKAVLAGF
>Mature_337_residues
MRAVAYNSPQPITAETSLIDIELPMPEARGHDLLVEIKAVSVNPADVKIRAHVAPPTDEPRVLGWDAAGIVKAVGADVTL
FKPGDQVFYSGALARSGTNAEFHLVDERIVGAKPKSLDFAAAAALPLTTITAYEALFDRLKVQDPVSGAARSILIIGGAG
GVGSIAIQIARVLTDLTVIATASRRETQDWVKDLGAHHVIDHSSPIAPQVAALGIGAPGFIFSTTNTDLHIGDIVEVIAP
QGRFALIDNPKTLDVVPFMRKSASIHWELMFTRPLFETPDMIEQHRLLNRISELVDAGKIRTTLSETIGPINAANLKKAH
AMVETGRMKGKAVLAGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=340, Percent_Identity=30.2941176470588, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI194239674, Length=293, Percent_Identity=30.3754266211604, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI13236495, Length=293, Percent_Identity=30.3754266211604, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=36.231884057971, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI24308257, Length=298, Percent_Identity=26.510067114094, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI18379349, Length=176, Percent_Identity=34.6590909090909, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI67078404, Length=194, Percent_Identity=31.4432989690722, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1790485, Length=172, Percent_Identity=31.9767441860465, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=357, Percent_Identity=29.9719887955182, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=240, Percent_Identity=32.9166666666667, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35985; Mature: 35985

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVAYNSPQPITAETSLIDIELPMPEARGHDLLVEIKAVSVNPADVKIRAHVAPPTDEP
CCCCCCCCCCCCEECCEEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCC
RVLGWDAAGIVKAVGADVTLFKPGDQVFYSGALARSGTNAEFHLVDERIVGAKPKSLDFA
EEEEECHHHHHHHHCCCEEEECCCCCEEEECCHHCCCCCCEEEEECCHHCCCCCCCCCHH
AAAALPLTTITAYEALFDRLKVQDPVSGAARSILIIGGAGGVGSIAIQIARVLTDLTVIA
HHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEE
TASRRETQDWVKDLGAHHVIDHSSPIAPQVAALGIGAPGFIFSTTNTDLHIGDIVEVIAP
ECCCHHHHHHHHHCCCCEEECCCCCCCCCHHEEECCCCCEEEECCCCCEEHHHHHHHHCC
QGRFALIDNPKTLDVVPFMRKSASIHWELMFTRPLFETPDMIEQHRLLNRISELVDAGKI
CCCEEEECCCCEEEEHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHH
RTTLSETIGPINAANLKKAHAMVETGRMKGKAVLAGF
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MRAVAYNSPQPITAETSLIDIELPMPEARGHDLLVEIKAVSVNPADVKIRAHVAPPTDEP
CCCCCCCCCCCCEECCEEEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCC
RVLGWDAAGIVKAVGADVTLFKPGDQVFYSGALARSGTNAEFHLVDERIVGAKPKSLDFA
EEEEECHHHHHHHHCCCEEEECCCCCEEEECCHHCCCCCCEEEEECCHHCCCCCCCCCHH
AAAALPLTTITAYEALFDRLKVQDPVSGAARSILIIGGAGGVGSIAIQIARVLTDLTVIA
HHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEE
TASRRETQDWVKDLGAHHVIDHSSPIAPQVAALGIGAPGFIFSTTNTDLHIGDIVEVIAP
ECCCHHHHHHHHHCCCCEEECCCCCCCCCHHEEECCCCCEEEECCCCCEEHHHHHHHHCC
QGRFALIDNPKTLDVVPFMRKSASIHWELMFTRPLFETPDMIEQHRLLNRISELVDAGKI
CCCEEEECCCCEEEEHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHH
RTTLSETIGPINAANLKKAHAMVETGRMKGKAVLAGF
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]