Click here to switch to the map view.

The map label for this gene is mdtG [H]

Identifier: 209548443

GI number: 209548443

Start: 859456

End: 860697

Strand: Reverse

Name: mdtG [H]

Synonym: Rleg2_0840

Alternate gene names: 209548443

Gene position: 860697-859456 (Counterclockwise)

Preceding gene: 209548445

Following gene: 209548441

Centisome position: 18.97

GC content: 64.9

Gene sequence:

>1242_bases
ATGACCGATACGGAATTGGACGCGGCGAGCGTGAGCGCAGGCTCGATCTACTGGAAGCGCAACCTGGCGATCTCGCTGAT
CGGCTCCTTCACCACCATCGTGGCGATGACGCTGCTGCTGCCTTTCCTGCCGCTTTATGTCGAGGAGCTCGGCGTCAGCG
ATCATGCGGCGATTGTGCAATGGTCTGGCATCGCCTATGGCGCCACCTTTCTGGCTGCGGCTCTGGTCGCGCCGCTCTGG
GGGCGGCTCGGCGATATTTACGGGCGCAAGCTGATGCTGGTGCGCGCGAGCCTCGGCATGACGCTGGCGATCTCGTTGAT
GGGCATGGCCGGCAATATCTGGCAGCTGGTGGCGCTGCGCCTCTTCGTCGGGCTTGCCGGCGGTTATTCCTCCGGCTCGA
TGGTGCTGGTGGCGACGCAGACGCCGAAAGACCGCTCGGCCTGGGCGCTCGGCCTCCTCTCCTCCGGTATCATGGCCGGC
AATCTCGTCGGGCCGCTGATCGGCGGAGCGCTGCCGCCGCTGATCGGCATCCGAGGCACCTTTCTCGCCGCCGGGGCGAT
GATCTTCCTCGCCTTTCTCGCCACGACCTTTTTGATCAAAGAGGAGAAGTCGCCGGCCCGCAAACAGGCGGCCAAGGCGA
GCGGCGGCTGGAAATCCATCGCCGACAAACGGCCTGTCATCGCCATGCTGGCGACCGGCATGCTGTTGATGTTCGCCAAT
ATGTCGATCGAGCCGATCATCACCGTCTATGTCGCGCAGATCGTGCCGGCCGCCGATGCGGTGACGATAATCTCCGGCAT
CGTCATGTCGGCGGCCGCCCTCGGCAGCATTCTTTCGGCCTCATGGCTCGGCAAGCTTGCCGACAGGATCGGTCATTGGC
CGGTGATTTCAGGCGCGCTCGCCGTCGCCGGGCTGCTGCTGATCCCGCAGGCCTTCGTCACCAGCGCCTGGCAGCTGATC
ATCCTGCGCTTCCTGATGGGCGCGGCGCTCGGCGGACTGCTGCCCTGCATCGCCGCTGTCATCCGTCACAGCGTGCCGGA
CAGTGCGGCCGGCAGCATTCTCGGGTTTTCCATTTCCTCGCAATATGTCGGCCAGGTGGCCGGCCCGATCCTCGGCGGCT
TCGTCGGCGGGCATATCGGCATGCGGGCGGTTTTCCTCGGCACCTCGGTGCTGCTTGTCGCCGGTGCTGCCTATGCCTGG
CTGGTGAGGCCAACAGATAAGCAGACATCCCACCTGGATTAG

Upstream 100 bases:

>100_bases
TTAACCGATTGCATCACGCAATCAGTATATCTAGCACTTTTACCCGAGATGATCCAGTTTCGGCGCAATCGCGCCCTCGT
GATCAATGCCGAGGCAAGGA

Downstream 100 bases:

>100_bases
CGCCGTCCGCAGATCAGTTCGACGCCGGAGCGGGCGATCGCTTCCAGCGTCTCGCGGCTGTCGCCGGCGCGGGCGCGCAC
GGCAAGCGAATGCATGACGG

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTDTELDAASVSAGSIYWKRNLAISLIGSFTTIVAMTLLLPFLPLYVEELGVSDHAAIVQWSGIAYGATFLAAALVAPLW
GRLGDIYGRKLMLVRASLGMTLAISLMGMAGNIWQLVALRLFVGLAGGYSSGSMVLVATQTPKDRSAWALGLLSSGIMAG
NLVGPLIGGALPPLIGIRGTFLAAGAMIFLAFLATTFLIKEEKSPARKQAAKASGGWKSIADKRPVIAMLATGMLLMFAN
MSIEPIITVYVAQIVPAADAVTIISGIVMSAAALGSILSASWLGKLADRIGHWPVISGALAVAGLLLIPQAFVTSAWQLI
ILRFLMGAALGGLLPCIAAVIRHSVPDSAAGSILGFSISSQYVGQVAGPILGGFVGGHIGMRAVFLGTSVLLVAGAAYAW
LVRPTDKQTSHLD

Sequences:

>Translated_413_residues
MTDTELDAASVSAGSIYWKRNLAISLIGSFTTIVAMTLLLPFLPLYVEELGVSDHAAIVQWSGIAYGATFLAAALVAPLW
GRLGDIYGRKLMLVRASLGMTLAISLMGMAGNIWQLVALRLFVGLAGGYSSGSMVLVATQTPKDRSAWALGLLSSGIMAG
NLVGPLIGGALPPLIGIRGTFLAAGAMIFLAFLATTFLIKEEKSPARKQAAKASGGWKSIADKRPVIAMLATGMLLMFAN
MSIEPIITVYVAQIVPAADAVTIISGIVMSAAALGSILSASWLGKLADRIGHWPVISGALAVAGLLLIPQAFVTSAWQLI
ILRFLMGAALGGLLPCIAAVIRHSVPDSAAGSILGFSISSQYVGQVAGPILGGFVGGHIGMRAVFLGTSVLLVAGAAYAW
LVRPTDKQTSHLD
>Mature_412_residues
TDTELDAASVSAGSIYWKRNLAISLIGSFTTIVAMTLLLPFLPLYVEELGVSDHAAIVQWSGIAYGATFLAAALVAPLWG
RLGDIYGRKLMLVRASLGMTLAISLMGMAGNIWQLVALRLFVGLAGGYSSGSMVLVATQTPKDRSAWALGLLSSGIMAGN
LVGPLIGGALPPLIGIRGTFLAAGAMIFLAFLATTFLIKEEKSPARKQAAKASGGWKSIADKRPVIAMLATGMLLMFANM
SIEPIITVYVAQIVPAADAVTIISGIVMSAAALGSILSASWLGKLADRIGHWPVISGALAVAGLLLIPQAFVTSAWQLII
LRFLMGAALGGLLPCIAAVIRHSVPDSAAGSILGFSISSQYVGQVAGPILGGFVGGHIGMRAVFLGTSVLLVAGAAYAWL
VRPTDKQTSHLD

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=414, Percent_Identity=40.3381642512077, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI87082404, Length=370, Percent_Identity=25.1351351351351, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42741; Mature: 42610

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTELDAASVSAGSIYWKRNLAISLIGSFTTIVAMTLLLPFLPLYVEELGVSDHAAIVQ
CCCCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEE
WSGIAYGATFLAAALVAPLWGRLGDIYGRKLMLVRASLGMTLAISLMGMAGNIWQLVALR
ECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHCCCHHHHHHHHH
LFVGLAGGYSSGSMVLVATQTPKDRSAWALGLLSSGIMAGNLVGPLIGGALPPLIGIRGT
HHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCHH
FLAAGAMIFLAFLATTFLIKEEKSPARKQAAKASGGWKSIADKRPVIAMLATGMLLMFAN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHC
MSIEPIITVYVAQIVPAADAVTIISGIVMSAAALGSILSASWLGKLADRIGHWPVISGAL
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AVAGLLLIPQAFVTSAWQLIILRFLMGAALGGLLPCIAAVIRHSVPDSAAGSILGFSISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHH
QYVGQVAGPILGGFVGGHIGMRAVFLGTSVLLVAGAAYAWLVRPTDKQTSHLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure 
TDTELDAASVSAGSIYWKRNLAISLIGSFTTIVAMTLLLPFLPLYVEELGVSDHAAIVQ
CCCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEE
WSGIAYGATFLAAALVAPLWGRLGDIYGRKLMLVRASLGMTLAISLMGMAGNIWQLVALR
ECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHCCCHHHHHHHHH
LFVGLAGGYSSGSMVLVATQTPKDRSAWALGLLSSGIMAGNLVGPLIGGALPPLIGIRGT
HHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCHH
FLAAGAMIFLAFLATTFLIKEEKSPARKQAAKASGGWKSIADKRPVIAMLATGMLLMFAN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHC
MSIEPIITVYVAQIVPAADAVTIISGIVMSAAALGSILSASWLGKLADRIGHWPVISGAL
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AVAGLLLIPQAFVTSAWQLIILRFLMGAALGGLLPCIAAVIRHSVPDSAAGSILGFSISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHH
QYVGQVAGPILGGFVGGHIGMRAVFLGTSVLLVAGAAYAWLVRPTDKQTSHLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA