Click here to switch to the map view.

The map label for this gene is higB [H]

Identifier: 209548378

GI number: 209548378

Start: 793060

End: 793353

Strand: Direct

Name: higB [H]

Synonym: Rleg2_0774

Alternate gene names: 209548378

Gene position: 793060-793353 (Clockwise)

Preceding gene: 209548376

Following gene: 209548379

Centisome position: 17.48

GC content: 50.68

Gene sequence:

>294_bases
ATGCACATCATCACGCAGAAAAAGATCTGGGAGGCGAAAGACCGATGGCCTCAAACGGCCAATGCTCTGGATACCTGGTA
TAGGCTGATGAAAGCGGCGGAATCGACGGATTTCGCTGACATGAAATCGCTCTTTCCGGCGACAGATAAGGTCGGGCAAC
ACCATGTATTCGACATTGGCGGGAATAAGCTCCGCCTGATTGCGATGGTGCACTACAGATTCAAGAAGGTCTATATTCAG
CGGATTATGGATCACGCGGAATACGACAAAGGAGCATGGAAGGGTCAAGCCTGA

Upstream 100 bases:

>100_bases
TGTTTGCCGGTCTCCGATCGCATCCATAGCAGCTTGCTATAATCGAATGGTTGCGCTAGATTGCGCATATAGCAAAATGC
GATTGCTCGATCTCGGATTC

Downstream 100 bases:

>100_bases
TGAGCGCACTTGTAAAACTGGTAAGCGAGCACTGGACGCATGTGGCCCCGCTTCTTGCCATGCCGGCCGATGAAGCTGAA
TATGATCATCTTGTGGAGCA

Product: hypothetical protein

Products: NA

Alternate protein names: Endoribonuclease HigB; Toxin HigB [H]

Number of amino acids: Translated: 97; Mature: 97

Protein sequence:

>97_residues
MHIITQKKIWEAKDRWPQTANALDTWYRLMKAAESTDFADMKSLFPATDKVGQHHVFDIGGNKLRLIAMVHYRFKKVYIQ
RIMDHAEYDKGAWKGQA

Sequences:

>Translated_97_residues
MHIITQKKIWEAKDRWPQTANALDTWYRLMKAAESTDFADMKSLFPATDKVGQHHVFDIGGNKLRLIAMVHYRFKKVYIQ
RIMDHAEYDKGAWKGQA
>Mature_97_residues
MHIITQKKIWEAKDRWPQTANALDTWYRLMKAAESTDFADMKSLFPATDKVGQHHVFDIGGNKLRLIAMVHYRFKKVYIQ
RIMDHAEYDKGAWKGQA

Specific function: Part of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase [H]

COG id: COG4680

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HigB mRNA interferase family [H]

Homologues:

Organism=Escherichia coli, GI1789465, Length=92, Percent_Identity=35.8695652173913, Blast_Score=72, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018669 [H]

Pfam domain/function: PF09907 DUF2136 [H]

EC number: NA

Molecular weight: Translated: 11409; Mature: 11409

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIITQKKIWEAKDRWPQTANALDTWYRLMKAAESTDFADMKSLFPATDKVGQHHVFDIG
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECC
GNKLRLIAMVHYRFKKVYIQRIMDHAEYDKGAWKGQA
CCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHIITQKKIWEAKDRWPQTANALDTWYRLMKAAESTDFADMKSLFPATDKVGQHHVFDIG
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECC
GNKLRLIAMVHYRFKKVYIQRIMDHAEYDKGAWKGQA
CCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]