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The map label for this gene is degP [H]

Identifier: 209548367

GI number: 209548367

Start: 778524

End: 780029

Strand: Reverse

Name: degP [H]

Synonym: Rleg2_0763

Alternate gene names: 209548367

Gene position: 780029-778524 (Counterclockwise)

Preceding gene: 209548370

Following gene: 209548365

Centisome position: 17.19

GC content: 65.54

Gene sequence:

>1506_bases
ATGTCACACATCCTCCGCAAACATCGCACTGCTGCCCTCATCGGGGCTGCCATCATCGCCGGCGCGGCATGCCTGCCGTT
TACCATTACCGCGGCGAACGCCGTTGCCTCGCCTGCGGATGCCGGCGGCATTCTCGCCGCCAGCGGCTCTTTCGCCTCTA
TCGTCGATGCCGACAAACCTGCCGTCGTCACCATCACCACGACCATGAAGGCAACCGATGTCAGCGCCGACCAGCAGCAG
TCGCCGATGGACGAGCAGTTCCGCCAGTTTTTCGAGGATCAGGGCATCCCGCTGCCGCGCCAGGCGCCGAAAAACCGGTC
TTCGCAGCAGACAATGGCGCTCGGCTCCGGCTTCATCATCAGCCCAGACGGCGTGATCGTTACCAACAACCATGTCATCG
ACAATGCCGTCGACATCAAGGTGACGCTGGATGACGGCACGGAACTGCCGGCCAAGCTGATCGGCACCGACCCGAAATCC
GATGTCGCCGTCGTGAAGATAGAGGCGGGAAAGCCGCTGCAGACCATTGCCTGGGGCGATTCCGACAGGCTGAAGCTCGG
CGACCAGATCCTGGCGATCGGCAACCCCTTCGGCATCGGCACCACGGTGACGGCGGGCATCGTCTCGGCGCGCGGCCGCG
ACCTGCACAGCGGGCCCTATGACGATTTCATCCAGATCGACGCGCCGATCAACCATGGCAACTCAGGCGGGCCGCTCGTC
GACCGCAGCGGCAATGTCGTCGGCATCAACACTGCGATCTATTCGCCGAACGGCGGCAGTGTCGGCGTCGGCTTCGCCAT
TCCGTCCGACGAGGCCAAGGCGATCGTCGCCAAACTGCAGAAGGACGGCTCGATCGATCACGGTTATCTCGGCGTGCAGA
TCCAGCCTGTGACGAAAGACGTCGCCGATGCCGTCGGCCTCGATAAAACAGGCGGCGCACTGGTTGCCGCCGTCACCGCC
GATACGCCGGCGGCCCATGCCGGCGTGAAGCCGGGCGATATCATCACCTCGGTCGGCGGCGAGAGCGTCAAGACGCCGAA
GGACCTGTCGCGGCTGGTCGCCGATCTTTCGCCAGGCGCCAAAAAATCTCTCGGCATCTGGCGTGACGGCAAGACGATCG
ATCTCAACGTCACCGTCGGCGGCAATGAGGACGGCCAGAAACAGGCCGCCGCCGAAAGCTCGGACAGCAAGGGCGAGAGC
AGCGGCCAGCCGAGCCTCGGCATCGGCCTCGCCGACCTGACGCCAGACGTGCGCGAGCAGCTCACCCTGCCGCGCGCCGT
CAGCGGCGCGGTGGTCGCCAGCGTCGATCCCGACAAGTCGGCCGCGGCCGCCGGCATCCAGTCGGGCGATGTCATCGTCT
CGGTCAACGACAGACCGGTCCACAGCACCCGCGACGTCAAGACCGCGATTGCCGAGGCCGGCAAGGCTGGCCGCAAATCG
GTGCTACTGCTCGTCGAACGCGATGGCGGCAAGACCTTCGTCGCCGTGCCGTTCGGTGCGGCCTGA

Upstream 100 bases:

>100_bases
TGGCGCCACCGCATCCGACGCCAGGTCCCAAGACATCGACCCATACGCCATGGAACCACGACGCCATCAAAACCCAACGC
TCTCGCAAGGGACCATCACC

Downstream 100 bases:

>100_bases
CGGCTCGAAGTCAAAGGAAAGCCCGTGAGAGCGGGCTTTCGACCAACCGAACCCCCTCGCGTTCAGCTCTCGCCAATCTA
TTGCGTCGAATTGCTGATGC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSHILRKHRTAALIGAAIIAGAACLPFTITAANAVASPADAGGILAASGSFASIVDADKPAVVTITTTMKATDVSADQQQ
SPMDEQFRQFFEDQGIPLPRQAPKNRSSQQTMALGSGFIISPDGVIVTNNHVIDNAVDIKVTLDDGTELPAKLIGTDPKS
DVAVVKIEAGKPLQTIAWGDSDRLKLGDQILAIGNPFGIGTTVTAGIVSARGRDLHSGPYDDFIQIDAPINHGNSGGPLV
DRSGNVVGINTAIYSPNGGSVGVGFAIPSDEAKAIVAKLQKDGSIDHGYLGVQIQPVTKDVADAVGLDKTGGALVAAVTA
DTPAAHAGVKPGDIITSVGGESVKTPKDLSRLVADLSPGAKKSLGIWRDGKTIDLNVTVGGNEDGQKQAAAESSDSKGES
SGQPSLGIGLADLTPDVREQLTLPRAVSGAVVASVDPDKSAAAAGIQSGDVIVSVNDRPVHSTRDVKTAIAEAGKAGRKS
VLLLVERDGGKTFVAVPFGAA

Sequences:

>Translated_501_residues
MSHILRKHRTAALIGAAIIAGAACLPFTITAANAVASPADAGGILAASGSFASIVDADKPAVVTITTTMKATDVSADQQQ
SPMDEQFRQFFEDQGIPLPRQAPKNRSSQQTMALGSGFIISPDGVIVTNNHVIDNAVDIKVTLDDGTELPAKLIGTDPKS
DVAVVKIEAGKPLQTIAWGDSDRLKLGDQILAIGNPFGIGTTVTAGIVSARGRDLHSGPYDDFIQIDAPINHGNSGGPLV
DRSGNVVGINTAIYSPNGGSVGVGFAIPSDEAKAIVAKLQKDGSIDHGYLGVQIQPVTKDVADAVGLDKTGGALVAAVTA
DTPAAHAGVKPGDIITSVGGESVKTPKDLSRLVADLSPGAKKSLGIWRDGKTIDLNVTVGGNEDGQKQAAAESSDSKGES
SGQPSLGIGLADLTPDVREQLTLPRAVSGAVVASVDPDKSAAAAGIQSGDVIVSVNDRPVHSTRDVKTAIAEAGKAGRKS
VLLLVERDGGKTFVAVPFGAA
>Mature_500_residues
SHILRKHRTAALIGAAIIAGAACLPFTITAANAVASPADAGGILAASGSFASIVDADKPAVVTITTTMKATDVSADQQQS
PMDEQFRQFFEDQGIPLPRQAPKNRSSQQTMALGSGFIISPDGVIVTNNHVIDNAVDIKVTLDDGTELPAKLIGTDPKSD
VAVVKIEAGKPLQTIAWGDSDRLKLGDQILAIGNPFGIGTTVTAGIVSARGRDLHSGPYDDFIQIDAPINHGNSGGPLVD
RSGNVVGINTAIYSPNGGSVGVGFAIPSDEAKAIVAKLQKDGSIDHGYLGVQIQPVTKDVADAVGLDKTGGALVAAVTAD
TPAAHAGVKPGDIITSVGGESVKTPKDLSRLVADLSPGAKKSLGIWRDGKTIDLNVTVGGNEDGQKQAAAESSDSKGESS
GQPSLGIGLADLTPDVREQLTLPRAVSGAVVASVDPDKSAAAAGIQSGDVIVSVNDRPVHSTRDVKTAIAEAGKAGRKSV
LLLVERDGGKTFVAVPFGAA

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=273, Percent_Identity=38.4615384615385, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=35.7142857142857, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI22129776, Length=265, Percent_Identity=35.4716981132075, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=33.5714285714286, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1786356, Length=438, Percent_Identity=38.1278538812785, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789629, Length=426, Percent_Identity=38.7323943661972, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1789630, Length=270, Percent_Identity=41.1111111111111, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24646839, Length=275, Percent_Identity=32.7272727272727, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50944; Mature: 50813

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHILRKHRTAALIGAAIIAGAACLPFTITAANAVASPADAGGILAASGSFASIVDADKP
CCHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHCCCCCCCCEEEECCCEEEEECCCCC
AVVTITTTMKATDVSADQQQSPMDEQFRQFFEDQGIPLPRQAPKNRSSQQTMALGSGFII
EEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEECCCEEE
SPDGVIVTNNHVIDNAVDIKVTLDDGTELPAKLIGTDPKSDVAVVKIEAGKPLQTIAWGD
CCCCEEEECCEEECCEEEEEEEECCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEECC
SDRLKLGDQILAIGNPFGIGTTVTAGIVSARGRDLHSGPYDDFIQIDAPINHGNSGGPLV
CCCEEECCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCEE
DRSGNVVGINTAIYSPNGGSVGVGFAIPSDEAKAIVAKLQKDGSIDHGYLGVQIQPVTKD
ECCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEEEECHHH
VADAVGLDKTGGALVAAVTADTPAAHAGVKPGDIITSVGGESVKTPKDLSRLVADLSPGA
HHHHCCCCCCCCEEEEEEECCCCCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCC
KKSLGIWRDGKTIDLNVTVGGNEDGQKQAAAESSDSKGESSGQPSLGIGLADLTPDVREQ
CCCCCEEECCCEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEHHHCCHHHHHH
LTLPRAVSGAVVASVDPDKSAAAAGIQSGDVIVSVNDRPVHSTRDVKTAIAEAGKAGRKS
HCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCE
VLLLVERDGGKTFVAVPFGAA
EEEEEECCCCCEEEEECCCCC
>Mature Secondary Structure 
SHILRKHRTAALIGAAIIAGAACLPFTITAANAVASPADAGGILAASGSFASIVDADKP
CHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHCCCCCCCCEEEECCCEEEEECCCCC
AVVTITTTMKATDVSADQQQSPMDEQFRQFFEDQGIPLPRQAPKNRSSQQTMALGSGFII
EEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEECCCEEE
SPDGVIVTNNHVIDNAVDIKVTLDDGTELPAKLIGTDPKSDVAVVKIEAGKPLQTIAWGD
CCCCEEEECCEEECCEEEEEEEECCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEECC
SDRLKLGDQILAIGNPFGIGTTVTAGIVSARGRDLHSGPYDDFIQIDAPINHGNSGGPLV
CCCEEECCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCEE
DRSGNVVGINTAIYSPNGGSVGVGFAIPSDEAKAIVAKLQKDGSIDHGYLGVQIQPVTKD
ECCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEEEECHHH
VADAVGLDKTGGALVAAVTADTPAAHAGVKPGDIITSVGGESVKTPKDLSRLVADLSPGA
HHHHCCCCCCCCEEEEEEECCCCCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCC
KKSLGIWRDGKTIDLNVTVGGNEDGQKQAAAESSDSKGESSGQPSLGIGLADLTPDVREQ
CCCCCEEECCCEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEHHHCCHHHHHH
LTLPRAVSGAVVASVDPDKSAAAAGIQSGDVIVSVNDRPVHSTRDVKTAIAEAGKAGRKS
HCCCCCCCCCEEEECCCCCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCE
VLLLVERDGGKTFVAVPFGAA
EEEEEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]