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The map label for this gene is cya1 [H]

Identifier: 209548319

GI number: 209548319

Start: 737609

End: 739522

Strand: Reverse

Name: cya1 [H]

Synonym: Rleg2_0714

Alternate gene names: 209548319

Gene position: 739522-737609 (Counterclockwise)

Preceding gene: 209548320

Following gene: 209548318

Centisome position: 16.3

GC content: 62.96

Gene sequence:

>1914_bases
GTGCGCTGGTCCAAACCGCTCAGACTGCATCTCGGCGTCCTGGTCGTCGCGTCGCTGCTTTGCACCTCGGCGCCGATCAT
CTGGATGGCATTCAGCCACGGAAGCGAAGCTGCGGTCAGCGCTGGCGCGCAGCAGATGCGCGCGATGAGCTTGCGGCTGA
TCGAGGGTTACCGGAATACGCTGCAGAGCGGCACCGAGGCCGTGGCGCTGGCCTCCACCCTGCCGCAGCTCGTTTCCCCG
CCGCCTGAAGATATCAAGGCAAAACAGCAATTCTTTCAGGAGGTTCTGCGAAACGTCCCGAACGCCACCAGCGTTTACGC
CGGCTATCCCGATGGCTCCTACCTGCAGGTGATCAACACGGCCCGGCGCGACGTCCGCCAGACGCTTGCCGCACCCGATG
GTACGGCTTTCGCGATCCGCATGATCGCGAGGCGACCAGCGGCCGATATCATCTCGACGCTTGGTTTTCTCGACAGCTAT
GCAAAGCTGATCGCGGAGCGGAGCATCGAGGATACCTCCTTCGATCCGCGGCAACGCCCCTGGTATCGATCCGTCATTCA
GGACGGCGCGCCGGTTTCCGTCGGACCCTATATCACCGGGACGCTGAATGTTCCGACGCTGACGATCGCCGCCCCGATGC
GGGACGACTGCAAGGTGGTGATCGGCATCAACATTCACCTGCAGACCGTCAGCCGGCTGCTCGACGCAGGCGAGATCTCA
CCGCGGGCCCGGGCCTATATCATCGATGACGACGGCAATCTCGTCGCCCATTCCGATCCTGATATCATGAGCAGGATCAT
CGCCTTGTGGTCGAGAACATCAGGCGCCTTTGCCACGACGGCAAACGGTTTCGACCCGAGCCTTAAAACCGTGGCGCGGC
TCAGGCAGGATCCGGCCTTCGCCGGCGGCGGCCTGGCACGGGTCGATTTCGATGGTGAAACCCATCTGGTGCAGATCGCC
CCGGTCAGCGTCTCCGGCCTGTTCACGGGCAGCGAGGCCGCCATCGTCGTGCCGTTGCAGGACCTGGTGGCGGAAGCCCA
TCGGCTGCTGGTGCGCAACCTCTTCATCGCCGCCGCCTTCGTGCTCGCCGGTGTCGGCGCCTCGGTGATGCTGTCGCGCA
TGGTCAGCCGCTCGCTCTATCGGCTGGCGGACGAGGCGCGCCGGATCGGCGATCTGGATGTGGGGGAGAAGCCGATGTCC
CACTCCTGGATCAGCGAGATCAACACGCTGGCAAACGCGCTGGCGGCCAGCCGTCATGCCATCGCTCAGTTTGCGCTTTA
TGTGCCGCGTGAAGTGGTCCGGCGGATCGTCAATCCCGAGACGAGAACGATCGTCAAGGCGAAGCGACAGGATGTGACCG
TGCTGTTCACCGACATCAAAGACTTCACCACCATCTCGGAACAACATTCGCCCGAAGAGGTGGTCGACACCCTTTCTGCC
TATTTCGAACTGCTGAACACCATCGCCGAGCGCAATGGCGGGGCCGTCGTGCAATATCTCGGCGATTCCATTTTCGTCAT
GTGGAACGCCCCGGTCGACGATACCAGCCATGCCGAACATGGCTGTCGATGCGCGCTGGCCATGAAAGCGGCGGTCGACG
GCTTGAACGAAACCAATCTCAGAAATGGCCGCCCGGAGTTGCTGACGCGCTTCGGATTGCACACCGGCCCGGCCGTCGTC
GGCAGCTTCGGGGCGATTTCGCGCCAGCAATATACGGCGATGGGCGATACGATCAATGTGGCGTCACGGCTGGAAGGCAT
GAACAAGGAGCTGAACACATCGATCCTGGTCAGCGCCGCCACCCGCGACGCCGTCGCCGACCGCTTCACCTTCCGCCCCC
TCGGCCTTGCCCCGGTCAAGGGACGCGCCGAGAAGGTCGACATTTGGGAGCTTGTCGGGGAAATCAAAGAGTGA

Upstream 100 bases:

>100_bases
AAGCCTGCAAAAAGCAGTTAGCTGGCATCGTTGGCTAGCGCATGCCGGACGGGCAATGCGCTATAATGCTGAGACGGGTC
CGCATTTCGGGGGAAATCGC

Downstream 100 bases:

>100_bases
TGATATGAAGGTCTTGCAGCCCTGCTGCTTCAGGATAGACTGATCATTGTCGGCGCTGTGCCGTGCGGTCCCCTCAATAG
CACCGGCGACCGGGCAAAAA

Product: adenylate/guanylate cyclase with integral membrane sensor

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MRWSKPLRLHLGVLVVASLLCTSAPIIWMAFSHGSEAAVSAGAQQMRAMSLRLIEGYRNTLQSGTEAVALASTLPQLVSP
PPEDIKAKQQFFQEVLRNVPNATSVYAGYPDGSYLQVINTARRDVRQTLAAPDGTAFAIRMIARRPAADIISTLGFLDSY
AKLIAERSIEDTSFDPRQRPWYRSVIQDGAPVSVGPYITGTLNVPTLTIAAPMRDDCKVVIGINIHLQTVSRLLDAGEIS
PRARAYIIDDDGNLVAHSDPDIMSRIIALWSRTSGAFATTANGFDPSLKTVARLRQDPAFAGGGLARVDFDGETHLVQIA
PVSVSGLFTGSEAAIVVPLQDLVAEAHRLLVRNLFIAAAFVLAGVGASVMLSRMVSRSLYRLADEARRIGDLDVGEKPMS
HSWISEINTLANALAASRHAIAQFALYVPREVVRRIVNPETRTIVKAKRQDVTVLFTDIKDFTTISEQHSPEEVVDTLSA
YFELLNTIAERNGGAVVQYLGDSIFVMWNAPVDDTSHAEHGCRCALAMKAAVDGLNETNLRNGRPELLTRFGLHTGPAVV
GSFGAISRQQYTAMGDTINVASRLEGMNKELNTSILVSAATRDAVADRFTFRPLGLAPVKGRAEKVDIWELVGEIKE

Sequences:

>Translated_637_residues
MRWSKPLRLHLGVLVVASLLCTSAPIIWMAFSHGSEAAVSAGAQQMRAMSLRLIEGYRNTLQSGTEAVALASTLPQLVSP
PPEDIKAKQQFFQEVLRNVPNATSVYAGYPDGSYLQVINTARRDVRQTLAAPDGTAFAIRMIARRPAADIISTLGFLDSY
AKLIAERSIEDTSFDPRQRPWYRSVIQDGAPVSVGPYITGTLNVPTLTIAAPMRDDCKVVIGINIHLQTVSRLLDAGEIS
PRARAYIIDDDGNLVAHSDPDIMSRIIALWSRTSGAFATTANGFDPSLKTVARLRQDPAFAGGGLARVDFDGETHLVQIA
PVSVSGLFTGSEAAIVVPLQDLVAEAHRLLVRNLFIAAAFVLAGVGASVMLSRMVSRSLYRLADEARRIGDLDVGEKPMS
HSWISEINTLANALAASRHAIAQFALYVPREVVRRIVNPETRTIVKAKRQDVTVLFTDIKDFTTISEQHSPEEVVDTLSA
YFELLNTIAERNGGAVVQYLGDSIFVMWNAPVDDTSHAEHGCRCALAMKAAVDGLNETNLRNGRPELLTRFGLHTGPAVV
GSFGAISRQQYTAMGDTINVASRLEGMNKELNTSILVSAATRDAVADRFTFRPLGLAPVKGRAEKVDIWELVGEIKE
>Mature_637_residues
MRWSKPLRLHLGVLVVASLLCTSAPIIWMAFSHGSEAAVSAGAQQMRAMSLRLIEGYRNTLQSGTEAVALASTLPQLVSP
PPEDIKAKQQFFQEVLRNVPNATSVYAGYPDGSYLQVINTARRDVRQTLAAPDGTAFAIRMIARRPAADIISTLGFLDSY
AKLIAERSIEDTSFDPRQRPWYRSVIQDGAPVSVGPYITGTLNVPTLTIAAPMRDDCKVVIGINIHLQTVSRLLDAGEIS
PRARAYIIDDDGNLVAHSDPDIMSRIIALWSRTSGAFATTANGFDPSLKTVARLRQDPAFAGGGLARVDFDGETHLVQIA
PVSVSGLFTGSEAAIVVPLQDLVAEAHRLLVRNLFIAAAFVLAGVGASVMLSRMVSRSLYRLADEARRIGDLDVGEKPMS
HSWISEINTLANALAASRHAIAQFALYVPREVVRRIVNPETRTIVKAKRQDVTVLFTDIKDFTTISEQHSPEEVVDTLSA
YFELLNTIAERNGGAVVQYLGDSIFVMWNAPVDDTSHAEHGCRCALAMKAAVDGLNETNLRNGRPELLTRFGLHTGPAVV
GSFGAISRQQYTAMGDTINVASRLEGMNKELNTSILVSAATRDAVADRFTFRPLGLAPVKGRAEKVDIWELVGEIKE

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI4580422, Length=229, Percent_Identity=31.8777292576419, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI167830411, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI222080083, Length=209, Percent_Identity=30.622009569378, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI134152694, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4504217, Length=189, Percent_Identity=30.6878306878307, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=183, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71983004, Length=261, Percent_Identity=24.904214559387, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561810, Length=262, Percent_Identity=25.9541984732824, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI86564713, Length=199, Percent_Identity=29.1457286432161, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193206632, Length=198, Percent_Identity=29.7979797979798, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995895, Length=180, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71995893, Length=180, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71995899, Length=180, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534657, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985505, Length=210, Percent_Identity=27.6190476190476, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982300, Length=176, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534649, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534653, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=145, Percent_Identity=31.7241379310345, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=168, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=190, Percent_Identity=28.4210526315789, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212659371, Length=147, Percent_Identity=30.6122448979592, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=190, Percent_Identity=28.4210526315789, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534655, Length=218, Percent_Identity=26.605504587156, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71996442, Length=184, Percent_Identity=29.3478260869565, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193205840, Length=178, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561800, Length=202, Percent_Identity=26.7326732673267, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=168, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17561802, Length=214, Percent_Identity=26.6355140186916, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI62484477, Length=202, Percent_Identity=30.6930693069307, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI62484298, Length=202, Percent_Identity=30.6930693069307, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI116008008, Length=202, Percent_Identity=30.6930693069307, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161078020, Length=183, Percent_Identity=34.4262295081967, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24647268, Length=214, Percent_Identity=33.1775700934579, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24663843, Length=194, Percent_Identity=30.9278350515464, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663839, Length=194, Percent_Identity=30.9278350515464, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574512, Length=180, Percent_Identity=28.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076872, Length=180, Percent_Identity=28.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366459, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281366457, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281366455, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI56292422, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI56292424, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666940, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 69152; Mature: 69152

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWSKPLRLHLGVLVVASLLCTSAPIIWMAFSHGSEAAVSAGAQQMRAMSLRLIEGYRNT
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQSGTEAVALASTLPQLVSPPPEDIKAKQQFFQEVLRNVPNATSVYAGYPDGSYLQVINT
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
ARRDVRQTLAAPDGTAFAIRMIARRPAADIISTLGFLDSYAKLIAERSIEDTSFDPRQRP
HHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
WYRSVIQDGAPVSVGPYITGTLNVPTLTIAAPMRDDCKVVIGINIHLQTVSRLLDAGEIS
HHHHHHCCCCCEEECCEEEEEECCCEEEEECCCCCCCEEEEEEEEEHHHHHHHHHCCCCC
PRARAYIIDDDGNLVAHSDPDIMSRIIALWSRTSGAFATTANGFDPSLKTVARLRQDPAF
CCCEEEEEECCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCC
AGGGLARVDFDGETHLVQIAPVSVSGLFTGSEAAIVVPLQDLVAEAHRLLVRNLFIAAAF
CCCCEEEEECCCCEEEEEEECEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
VLAGVGASVMLSRMVSRSLYRLADEARRIGDLDVGEKPMSHSWISEINTLANALAASRHA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQFALYVPREVVRRIVNPETRTIVKAKRQDVTVLFTDIKDFTTISEQHSPEEVVDTLSA
HHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHH
YFELLNTIAERNGGAVVQYLGDSIFVMWNAPVDDTSHAEHGCRCALAMKAAVDGLNETNL
HHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
RNGRPELLTRFGLHTGPAVVGSFGAISRQQYTAMGDTINVASRLEGMNKELNTSILVSAA
CCCCHHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEH
TRDAVADRFTFRPLGLAPVKGRAEKVDIWELVGEIKE
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRWSKPLRLHLGVLVVASLLCTSAPIIWMAFSHGSEAAVSAGAQQMRAMSLRLIEGYRNT
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQSGTEAVALASTLPQLVSPPPEDIKAKQQFFQEVLRNVPNATSVYAGYPDGSYLQVINT
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
ARRDVRQTLAAPDGTAFAIRMIARRPAADIISTLGFLDSYAKLIAERSIEDTSFDPRQRP
HHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
WYRSVIQDGAPVSVGPYITGTLNVPTLTIAAPMRDDCKVVIGINIHLQTVSRLLDAGEIS
HHHHHHCCCCCEEECCEEEEEECCCEEEEECCCCCCCEEEEEEEEEHHHHHHHHHCCCCC
PRARAYIIDDDGNLVAHSDPDIMSRIIALWSRTSGAFATTANGFDPSLKTVARLRQDPAF
CCCEEEEEECCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCC
AGGGLARVDFDGETHLVQIAPVSVSGLFTGSEAAIVVPLQDLVAEAHRLLVRNLFIAAAF
CCCCEEEEECCCCEEEEEEECEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
VLAGVGASVMLSRMVSRSLYRLADEARRIGDLDVGEKPMSHSWISEINTLANALAASRHA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQFALYVPREVVRRIVNPETRTIVKAKRQDVTVLFTDIKDFTTISEQHSPEEVVDTLSA
HHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHH
YFELLNTIAERNGGAVVQYLGDSIFVMWNAPVDDTSHAEHGCRCALAMKAAVDGLNETNL
HHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
RNGRPELLTRFGLHTGPAVVGSFGAISRQQYTAMGDTINVASRLEGMNKELNTSILVSAA
CCCCHHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEH
TRDAVADRFTFRPLGLAPVKGRAEKVDIWELVGEIKE
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]