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The map label for this gene is tetA [H]

Identifier: 209548287

GI number: 209548287

Start: 711215

End: 712408

Strand: Reverse

Name: tetA [H]

Synonym: Rleg2_0682

Alternate gene names: 209548287

Gene position: 712408-711215 (Counterclockwise)

Preceding gene: 209548288

Following gene: 209548285

Centisome position: 15.7

GC content: 65.49

Gene sequence:

>1194_bases
ATGACCAGATCCCTTATCGTCATCTTCACCGCCATTGTCCTCGATGCCGTCGGCATCGGGTTGATTTTCCCGATCCTGCC
GTCGCTGCTGCGCGATATCACCCATGCCGAAAACGTCGCGCCCTTTATCGGCACGATGACCGCGCTCTATGCGGTGATGC
AGTTCATCTTCGCGCCCGTGCTCGGGGCGCTGAGCGATCGGCTTGGCCGCCGCCCCGTGCTGCTGATTTCGCTTGCCGGC
GCCGCCGTCAACTACTTGTTTCTCGCCTTTGCGCCCAATCTCGCGCTGCTGTTCGTCGGCCGGGCGATTGCCGGGCTGAC
CAGCGCCAATATCTCGGTGGCGACAGCCTATATCACCGATATTTCACCCGAGGAGAAACGCGCCCGCCGCTTCGGACTGT
TCAACGCGATGTTCGGCCTCGGCTTCATCATCGGCCCGGTGCTCGGCGGTGTGCTCGGCGATCATTGGCTGCGGCTGCCG
TTCATCGCGGCCGCCGTGCTCAATGGCGCCAACCTGCTGCTTGCCTTCTTCATCCTTCCGGAATCGCGCCCGGGCAGCCG
CGAGAAGATCGATCTGGCGGCGCTCAATCCCCTCCGACCGCTGCGTTCGGTGCTGGAGGTCAAGAGCCTGCTGCCCGTCG
TCATCCTGTTCTTCATCTTCAGCGCCACCGGCGAGGCCTACGGCACCTGCTGGGCGCTGTGGGGCAGCGACGCCTTCCAC
TGGAACGGGCTGTCGATCGGCCTTTCCCTCGGCGCCTTCGGCATCTGCCAGACGCTGGCCCAGGCCTTGCTGCCGGGACC
GGCCGTCAGGCTGCTCGGCGAACGCGCGGCGATCCTCACCGGTGTCATCGGCGTCTGCATCGCACTGACCGTCATGGCCT
TTGCCGGGAGCGGCTGGGTGATCCTCGCGATCATGCCAGTCTTCGCGCTCGGCGGCATCGGCGTTCCGGCGCTGCAATCG
CTGGCGACCCGACAGGTCGATGAAGATAGCCAGGGCCAGTTCCAGGGCGTGCTGGCCTCCGCCGTCAGCCTCGCCTCGAT
CGTCGCGCCGCTTGGCTTTTCCAGCGTCTATTTCCTTGTGAGGGAGACGTGGCCGGGCGCCATCTGGCTATCGGTGGTCG
TCGTTTACGGGCTCGCGGTGCCGCTGGTTCTCGGCTTGCGGCTGAAGACGGCGGAGCGGGCGCCTGTGAGTTAG

Upstream 100 bases:

>100_bases
GCCTCATCGTGAGCCATCGGCGTCCCGATGCAATTCCGTGATTTGGAAAATCAGGGAGGCGCTGACGGTCCTGCCGGCTT
GCGTCGACCCGGAACGCACC

Downstream 100 bases:

>100_bases
CCAGGCGCCGCAAGGCCATGCCACGCTAAATGAGCGCGGCGGTGCCACTGTCGAACAGGGAATGATCATCGAGGACGTTG
GCGGCCAGCATCGCGCCTTC

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTRSLIVIFTAIVLDAVGIGLIFPILPSLLRDITHAENVAPFIGTMTALYAVMQFIFAPVLGALSDRLGRRPVLLISLAG
AAVNYLFLAFAPNLALLFVGRAIAGLTSANISVATAYITDISPEEKRARRFGLFNAMFGLGFIIGPVLGGVLGDHWLRLP
FIAAAVLNGANLLLAFFILPESRPGSREKIDLAALNPLRPLRSVLEVKSLLPVVILFFIFSATGEAYGTCWALWGSDAFH
WNGLSIGLSLGAFGICQTLAQALLPGPAVRLLGERAAILTGVIGVCIALTVMAFAGSGWVILAIMPVFALGGIGVPALQS
LATRQVDEDSQGQFQGVLASAVSLASIVAPLGFSSVYFLVRETWPGAIWLSVVVVYGLAVPLVLGLRLKTAERAPVS

Sequences:

>Translated_397_residues
MTRSLIVIFTAIVLDAVGIGLIFPILPSLLRDITHAENVAPFIGTMTALYAVMQFIFAPVLGALSDRLGRRPVLLISLAG
AAVNYLFLAFAPNLALLFVGRAIAGLTSANISVATAYITDISPEEKRARRFGLFNAMFGLGFIIGPVLGGVLGDHWLRLP
FIAAAVLNGANLLLAFFILPESRPGSREKIDLAALNPLRPLRSVLEVKSLLPVVILFFIFSATGEAYGTCWALWGSDAFH
WNGLSIGLSLGAFGICQTLAQALLPGPAVRLLGERAAILTGVIGVCIALTVMAFAGSGWVILAIMPVFALGGIGVPALQS
LATRQVDEDSQGQFQGVLASAVSLASIVAPLGFSSVYFLVRETWPGAIWLSVVVVYGLAVPLVLGLRLKTAERAPVS
>Mature_396_residues
TRSLIVIFTAIVLDAVGIGLIFPILPSLLRDITHAENVAPFIGTMTALYAVMQFIFAPVLGALSDRLGRRPVLLISLAGA
AVNYLFLAFAPNLALLFVGRAIAGLTSANISVATAYITDISPEEKRARRFGLFNAMFGLGFIIGPVLGGVLGDHWLRLPF
IAAAVLNGANLLLAFFILPESRPGSREKIDLAALNPLRPLRSVLEVKSLLPVVILFFIFSATGEAYGTCWALWGSDAFHW
NGLSIGLSLGAFGICQTLAQALLPGPAVRLLGERAAILTGVIGVCIALTVMAFAGSGWVILAIMPVFALGGIGVPALQSL
ATRQVDEDSQGQFQGVLASAVSLASIVAPLGFSSVYFLVRETWPGAIWLSVVVVYGLAVPLVLGLRLKTAERAPVS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=328, Percent_Identity=25.3048780487805, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI225703104, Length=388, Percent_Identity=28.0927835051546, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI225703102, Length=388, Percent_Identity=28.0927835051546, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI94721311, Length=360, Percent_Identity=23.3333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217416366, Length=190, Percent_Identity=32.6315789473684, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71996331, Length=331, Percent_Identity=24.4712990936556, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551570, Length=179, Percent_Identity=29.608938547486, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319871, Length=153, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17738085, Length=339, Percent_Identity=25.6637168141593, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357569, Length=369, Percent_Identity=26.2872628726287, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221513297, Length=326, Percent_Identity=26.0736196319018, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656463, Length=350, Percent_Identity=26, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24656468, Length=350, Percent_Identity=26, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI161080926, Length=350, Percent_Identity=26, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI161080924, Length=350, Percent_Identity=26, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41861; Mature: 41730

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSLIVIFTAIVLDAVGIGLIFPILPSLLRDITHAENVAPFIGTMTALYAVMQFIFAPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGALSDRLGRRPVLLISLAGAAVNYLFLAFAPNLALLFVGRAIAGLTSANISVATAYITD
HHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEEC
ISPEEKRARRFGLFNAMFGLGFIIGPVLGGVLGDHWLRLPFIAAAVLNGANLLLAFFILP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
ESRPGSREKIDLAALNPLRPLRSVLEVKSLLPVVILFFIFSATGEAYGTCWALWGSDAFH
CCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCEE
WNGLSIGLSLGAFGICQTLAQALLPGPAVRLLGERAAILTGVIGVCIALTVMAFAGSGWV
ECCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ILAIMPVFALGGIGVPALQSLATRQVDEDSQGQFQGVLASAVSLASIVAPLGFSSVYFLV
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RETWPGAIWLSVVVVYGLAVPLVLGLRLKTAERAPVS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TRSLIVIFTAIVLDAVGIGLIFPILPSLLRDITHAENVAPFIGTMTALYAVMQFIFAPV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGALSDRLGRRPVLLISLAGAAVNYLFLAFAPNLALLFVGRAIAGLTSANISVATAYITD
HHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEEC
ISPEEKRARRFGLFNAMFGLGFIIGPVLGGVLGDHWLRLPFIAAAVLNGANLLLAFFILP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
ESRPGSREKIDLAALNPLRPLRSVLEVKSLLPVVILFFIFSATGEAYGTCWALWGSDAFH
CCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCEE
WNGLSIGLSLGAFGICQTLAQALLPGPAVRLLGERAAILTGVIGVCIALTVMAFAGSGWV
ECCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ILAIMPVFALGGIGVPALQSLATRQVDEDSQGQFQGVLASAVSLASIVAPLGFSSVYFLV
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RETWPGAIWLSVVVVYGLAVPLVLGLRLKTAERAPVS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]