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The map label for this gene is fabI1 [H]

Identifier: 209548197

GI number: 209548197

Start: 617502

End: 618320

Strand: Reverse

Name: fabI1 [H]

Synonym: Rleg2_0591

Alternate gene names: 209548197

Gene position: 618320-617502 (Counterclockwise)

Preceding gene: 209548198

Following gene: 209548196

Centisome position: 13.63

GC content: 61.05

Gene sequence:

>819_bases
ATGGCTCAAGCATCCGGCCTCATGGCAGGCAAACGCGGCGTCATCATGGGTGTCGCCAACAATCGCTCGATTGCGTGGGG
TATTGCCAAGGCCATTCATGCGCAGGGCGGAGAAGTTGCGCTCACCTACCAGGGCGATGCGCTGAAGAAGCGCGTCGAGC
CGCTCGCCGCCGAAATCGGCGCGACGCTGGTCGGCCACTGTGACGTTGCCGACGAAGCCACCATCGACGAGGTTTTCGGA
AACGTCGAAAAGCTCTGGGGCAAGATCGATTTCCTCGTGCATGCGATCGGCTTCTCAGACAAGGATGAGCTGACCGGCCG
CTACGTCGACACCTCGGCCGACAACTTCGCCAAGACGATGCAGATCTCCGTCTATTCCTTCACCTCGGTCGCACGCCGCG
CCGAGAAGCTGATGACGGATGGCGGCGCCATGCTGACGCTGACCTATTATGGCGCCGAAAAGGTGATGCCGAACTATAAC
GTCATGGGTGTCGCCAAGGCCGCGCTAGAAGCGAGCGTCAAGTATCTGGCCGTCGACCTTGGACCGCAGAACATCCGCGT
CAACGCCGTCTCGGCCGGCCCGATCAAGACGCTTGCAGCCTCCGGCATCGGCGATTTCCGCTATATTCTGAAGTGGAACG
AATATAACGCGCCGCTGCGCCGCACCGTCACCATCGAGGAAGTCGGCGATGTCGGCCTCTATCTGCTGTCCGACCTCTCG
CGCTCCGTCACCGGCGAAGTGCACCATGCCGACAGCGGCTATCATGTCATCGGCATGAAGGCGGTCGACGCCCCTGACAT
TTCGGTCGTCAAGGACTGA

Upstream 100 bases:

>100_bases
TTTGTTACGAAACCTAACAGTTGATGATCCAGGCCAAGCTTGAACCGATTAGCGGCCTATGCCATAGGCAGGATCAATCA
GAATTCCTAGGGAGCGAAAT

Downstream 100 bases:

>100_bases
AGCATTCCCGGAGCAGAGACCGTGCTTATCTACGTGATCAGACACGGTCAGACCGACTGGAATGCCGAGCGCCGCCTGCA
GGGCCAGAAGGACATCCCGA

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAQASGLMAGKRGVIMGVANNRSIAWGIAKAIHAQGGEVALTYQGDALKKRVEPLAAEIGATLVGHCDVADEATIDEVFG
NVEKLWGKIDFLVHAIGFSDKDELTGRYVDTSADNFAKTMQISVYSFTSVARRAEKLMTDGGAMLTLTYYGAEKVMPNYN
VMGVAKAALEASVKYLAVDLGPQNIRVNAVSAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDVGLYLLSDLS
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD

Sequences:

>Translated_272_residues
MAQASGLMAGKRGVIMGVANNRSIAWGIAKAIHAQGGEVALTYQGDALKKRVEPLAAEIGATLVGHCDVADEATIDEVFG
NVEKLWGKIDFLVHAIGFSDKDELTGRYVDTSADNFAKTMQISVYSFTSVARRAEKLMTDGGAMLTLTYYGAEKVMPNYN
VMGVAKAALEASVKYLAVDLGPQNIRVNAVSAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDVGLYLLSDLS
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
>Mature_271_residues
AQASGLMAGKRGVIMGVANNRSIAWGIAKAIHAQGGEVALTYQGDALKKRVEPLAAEIGATLVGHCDVADEATIDEVFGN
VEKLWGKIDFLVHAIGFSDKDELTGRYVDTSADNFAKTMQISVYSFTSVARRAEKLMTDGGAMLTLTYYGAEKVMPNYNV
MGVAKAALEASVKYLAVDLGPQNIRVNAVSAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDVGLYLLSDLSR
SVTGEVHHADSGYHVIGMKAVDAPDISVVKD

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=24.031007751938, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=50.1930501930502, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=29.9212598425197, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=26.9961977186312, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=226, Percent_Identity=25.2212389380531, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29087; Mature: 28955

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQASGLMAGKRGVIMGVANNRSIAWGIAKAIHAQGGEVALTYQGDALKKRVEPLAAEIG
CCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHC
ATLVGHCDVADEATIDEVFGNVEKLWGKIDFLVHAIGFSDKDELTGRYVDTSADNFAKTM
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCEEECCCCHHHHEEE
QISVYSFTSVARRAEKLMTDGGAMLTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDL
EEEEEHHHHHHHHHHHHHCCCCEEEEEEEECHHHCCCCCCCHHHHHHHHHHCEEEEEEEE
GPQNIRVNAVSAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDVGLYLLSDLS
CCCEEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHHHCCHHHHHHHHHH
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
HHHCCCEEECCCCEEEEEEEEECCCCCEEECC
>Mature Secondary Structure 
AQASGLMAGKRGVIMGVANNRSIAWGIAKAIHAQGGEVALTYQGDALKKRVEPLAAEIG
CCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHC
ATLVGHCDVADEATIDEVFGNVEKLWGKIDFLVHAIGFSDKDELTGRYVDTSADNFAKTM
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCEEECCCCHHHHEEE
QISVYSFTSVARRAEKLMTDGGAMLTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDL
EEEEEHHHHHHHHHHHHHCCCCEEEEEEEECHHHCCCCCCCHHHHHHHHHHCEEEEEEEE
GPQNIRVNAVSAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDVGLYLLSDLS
CCCEEEEEEECCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHHHCCHHHHHHHHHH
RSVTGEVHHADSGYHVIGMKAVDAPDISVVKD
HHHCCCEEECCCCEEEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]