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The map label for this gene is ribBA [H]

Identifier: 209548191

GI number: 209548191

Start: 610266

End: 611369

Strand: Reverse

Name: ribBA [H]

Synonym: Rleg2_0585

Alternate gene names: 209548191

Gene position: 611369-610266 (Counterclockwise)

Preceding gene: 209548192

Following gene: 209548189

Centisome position: 13.47

GC content: 63.32

Gene sequence:

>1104_bases
ATGTCGTATGATCAAAAGCGCGTCGTCGACGCCATCCGGGCCTTCGAGGCCGGCGAGATCGTCGTCGTCATGGACGACAA
CGACCGCGAGAACGAGGGCGACCTGATCGTCGCCGCCGTCCATACCACGCCTGAAAAAATGGCCTTCATCGTGCGCCACA
CATCCGGCATCGTCTGCGCGCCGATGCCGAAGGAGGAGGCCAAGCGCCTCAACCTCAACGCCATGGTGGCGGAAAACGAT
TCGGCCCATACGACGGCCTTCACCGTCTCGGTCGATTTCAAGCACGGCACGACGACCGGCATCTCAGCCGACGACCGGAC
GCTGACGGTGCGCAACCTCGCCAATCCGAATGTCGGCGCCGCCGATTTCGTCCGTCCCGGCCATATCTTCCCGCTGGTTT
CGCGCGAAGGCGGCGTGCTGATGCGCTCCGGCCATACGGAAGCCGCCGTCGACCTCTGCAAACTCGCCGGCCTGCCGCCG
ATCGGCGTTATCTCCGAACTCGTCAATGACGACGGCACCGTCACGCGCGGTCCGCAGGTGGTCGATTTCGCCGAGCAGCA
CGGGTTGAAGCTCGTCTCCGTCGCCGATCTCATCGCCTATCGCCAGCGCAAGGAAACGCTGGTCGAGCACGGCACGAGCT
TCGACATCGACACACCATTCGGCAAGGCCAAGGCTCATACCTATTCCCTGCCCTGGGACCCGATGCAGCATCTCGCCGTC
GTCTTCGGCGACATCCGCGACGGCGTCGACATCCCGGTGCGCCTGCATCCAGAGAATGTCGCCGAGGATCTCTTCGGCAA
GAACAGCCCGGTCGATTTCTACATGCAGAAGATTTCCGAGGAAGGCCGCGGCGTCATCGTCTATCTGCGTGAAGGCTCGG
TCGGCGTCGGCCATTACGACAACGGCCGCAAGGCCCGCAACCAGGGCCGCGAAGCCCATGCCGAAGCCCAGACGCGCGAC
AGCGAATGGCTGGAAATCGGCCTCGGCGCCCAGATCCTCAAGGACCTCGGCGTCAGCTCAATCAAGCTGCTGACCAGCCG
CGAACGCCACTATGTCGGCCTGGAAGGTTTCGGCATCAAGATCAGCAAGACGGAGATCTGCTGA

Upstream 100 bases:

>100_bases
CCGCGCCGTGCCGATCGGCGAGGCGATGGTCGCCTGCGCCATCGCCGACCATTATCTTCGCGACCGCGGCCAGACCGGCC
GTCTGAAATAGGAGCGCCCC

Downstream 100 bases:

>100_bases
GGGTTTCTCCTCCCTCATCACGATCAATCAGGCCGTGACCGACTGCCTGATTTCGCTAGCGGATGGCGGCTGATACGGGC
ATCTGCGGTGTGAATGTGTC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSYDQKRVVDAIRAFEAGEIVVVMDDNDRENEGDLIVAAVHTTPEKMAFIVRHTSGIVCAPMPKEEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGAADFVRPGHIFPLVSREGGVLMRSGHTEAAVDLCKLAGLPP
IGVISELVNDDGTVTRGPQVVDFAEQHGLKLVSVADLIAYRQRKETLVEHGTSFDIDTPFGKAKAHTYSLPWDPMQHLAV
VFGDIRDGVDIPVRLHPENVAEDLFGKNSPVDFYMQKISEEGRGVIVYLREGSVGVGHYDNGRKARNQGREAHAEAQTRD
SEWLEIGLGAQILKDLGVSSIKLLTSRERHYVGLEGFGIKISKTEIC

Sequences:

>Translated_367_residues
MSYDQKRVVDAIRAFEAGEIVVVMDDNDRENEGDLIVAAVHTTPEKMAFIVRHTSGIVCAPMPKEEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGAADFVRPGHIFPLVSREGGVLMRSGHTEAAVDLCKLAGLPP
IGVISELVNDDGTVTRGPQVVDFAEQHGLKLVSVADLIAYRQRKETLVEHGTSFDIDTPFGKAKAHTYSLPWDPMQHLAV
VFGDIRDGVDIPVRLHPENVAEDLFGKNSPVDFYMQKISEEGRGVIVYLREGSVGVGHYDNGRKARNQGREAHAEAQTRD
SEWLEIGLGAQILKDLGVSSIKLLTSRERHYVGLEGFGIKISKTEIC
>Mature_366_residues
SYDQKRVVDAIRAFEAGEIVVVMDDNDRENEGDLIVAAVHTTPEKMAFIVRHTSGIVCAPMPKEEAKRLNLNAMVAENDS
AHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGAADFVRPGHIFPLVSREGGVLMRSGHTEAAVDLCKLAGLPPI
GVISELVNDDGTVTRGPQVVDFAEQHGLKLVSVADLIAYRQRKETLVEHGTSFDIDTPFGKAKAHTYSLPWDPMQHLAVV
FGDIRDGVDIPVRLHPENVAEDLFGKNSPVDFYMQKISEEGRGVIVYLREGSVGVGHYDNGRKARNQGREAHAEAQTRDS
EWLEIGLGAQILKDLGVSSIKLLTSRERHYVGLEGFGIKISKTEIC

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=49.5, Blast_Score=202, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=49.7512437810945, Blast_Score=196, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40117; Mature: 39986

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDQKRVVDAIRAFEAGEIVVVMDDNDRENEGDLIVAAVHTTPEKMAFIVRHTSGIVCA
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMPKEEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGA
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
ADFVRPGHIFPLVSREGGVLMRSGHTEAAVDLCKLAGLPPIGVISELVNDDGTVTRGPQV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCE
VDFAEQHGLKLVSVADLIAYRQRKETLVEHGTSFDIDTPFGKAKAHTYSLPWDPMQHLAV
EEHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VFGDIRDGVDIPVRLHPENVAEDLFGKNSPVDFYMQKISEEGRGVIVYLREGSVGVGHYD
HHHHHCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEECCCEECCCCC
NGRKARNQGREAHAEAQTRDSEWLEIGLGAQILKDLGVSSIKLLTSRERHYVGLEGFGIK
CCHHHHHCCCHHHHHHHCCCCCEEEECCCHHHHHHCCCCCEEEEECCCCEEEEEECCCEE
ISKTEIC
EECCCCC
>Mature Secondary Structure 
SYDQKRVVDAIRAFEAGEIVVVMDDNDRENEGDLIVAAVHTTPEKMAFIVRHTSGIVCA
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMPKEEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANPNVGA
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
ADFVRPGHIFPLVSREGGVLMRSGHTEAAVDLCKLAGLPPIGVISELVNDDGTVTRGPQV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCE
VDFAEQHGLKLVSVADLIAYRQRKETLVEHGTSFDIDTPFGKAKAHTYSLPWDPMQHLAV
EEHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VFGDIRDGVDIPVRLHPENVAEDLFGKNSPVDFYMQKISEEGRGVIVYLREGSVGVGHYD
HHHHHCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEECCCEECCCCC
NGRKARNQGREAHAEAQTRDSEWLEIGLGAQILKDLGVSSIKLLTSRERHYVGLEGFGIK
CCHHHHHCCCHHHHHHHCCCCCEEEECCCHHHHHHCCCCCEEEEECCCCEEEEEECCCEE
ISKTEIC
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]