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The map label for this gene is nhaA [H]

Identifier: 209548133

GI number: 209548133

Start: 541417

End: 542277

Strand: Direct

Name: nhaA [H]

Synonym: Rleg2_0527

Alternate gene names: 209548133

Gene position: 541417-542277 (Clockwise)

Preceding gene: 209548131

Following gene: 209548134

Centisome position: 11.93

GC content: 63.07

Gene sequence:

>861_bases
ATGGCCGGATTCTGGAGAAAGCTGCTGCCGAAACGGTTCCGCAAGAACGGCATCACCATCCCGGTCGTCAGATTGCAGGG
GCCGATCGTCAGCGGCGGCGGCCCGTTTCGGCCGGCCCTCAATCTCGCCAATGTCGCTCCGGTTCTGGAAAAGGCCTTCG
CCATGAAGGACGCGCCGGCGGTTGCCATAACGATCAATTCGCCGGGCGGTTCGCCCGTCCAGTCCCGCCTGATCTTCACC
CGCATTCGCGAACTCGCCCGCGAGAAGCAGAAGAAGGTCCTGGTCTTCGTCGAGGATGTTGCCGCCTCCGGCGGCTACAT
GATCGCGCTCGCCGGCGACGAGATCATTGCCGACTCGACCTCGATCGTCGGCTCGATCGGCGTCGTCTCCGGCGGTTTCG
GCTTTCCCGAACTTTTGAAGAAGATCGGCGTCGAGCGCCGTGTCTATACCGCTGGCGAAAACAAGGTGATCCTCGATCCG
TTCCAGCCGGAAAAGGAAAAGGACATTGAATATCTGAAGAGCCTGCAGCTCGAAATTCATCAGGTCTTCATCTCGATGGT
GCGCGAGCGCCGCGCTGGCAAGCTGAGGGACGATGCGGCGGTCTTCTCAGGCCTGTTCTGGAGCGGCACGCGCGGCCTCG
AACTCGGCCTCGTCGACGGCCTCGGCGACATGCGCCAGGAATTGAAGCGGCGCTACGGCCAGAAGACCAAGCTGGAGCTC
GTCGCCGCCGGCCGCGGCCTGTTCGGCCGCCGTGTTCCCGGCGTGTCGCCGGTTTCGCTCGAAAGTGCTGCATCCGGCCT
CGCGACAGGGCTTGTCGAAGCGGCGGAAGAAAGAGCATTGTGGAGCCGCTTCGGACTTTGA

Upstream 100 bases:

>100_bases
TGTTTTCGAGAACGCGGCCATTGCGTTTGTCGTTCCAGCGCATACATGGATGCCGATCGTCATTGACGCGATCGTGCGAC
CCGAAAGCGAAGGATTAGAG

Downstream 100 bases:

>100_bases
GGGGAGCAAGAGAGGGAAATGGCGCAGCTTATCACCATCCTGGTCCTGGTGTTCTCAGCCTGGTGGCTCTACCGCCGCTT
CGTCTCCGACGCCCGCAAGC

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MAGFWRKLLPKRFRKNGITIPVVRLQGPIVSGGGPFRPALNLANVAPVLEKAFAMKDAPAVAITINSPGGSPVQSRLIFT
RIRELAREKQKKVLVFVEDVAASGGYMIALAGDEIIADSTSIVGSIGVVSGGFGFPELLKKIGVERRVYTAGENKVILDP
FQPEKEKDIEYLKSLQLEIHQVFISMVRERRAGKLRDDAAVFSGLFWSGTRGLELGLVDGLGDMRQELKRRYGQKTKLEL
VAAGRGLFGRRVPGVSPVSLESAASGLATGLVEAAEERALWSRFGL

Sequences:

>Translated_286_residues
MAGFWRKLLPKRFRKNGITIPVVRLQGPIVSGGGPFRPALNLANVAPVLEKAFAMKDAPAVAITINSPGGSPVQSRLIFT
RIRELAREKQKKVLVFVEDVAASGGYMIALAGDEIIADSTSIVGSIGVVSGGFGFPELLKKIGVERRVYTAGENKVILDP
FQPEKEKDIEYLKSLQLEIHQVFISMVRERRAGKLRDDAAVFSGLFWSGTRGLELGLVDGLGDMRQELKRRYGQKTKLEL
VAAGRGLFGRRVPGVSPVSLESAASGLATGLVEAAEERALWSRFGL
>Mature_285_residues
AGFWRKLLPKRFRKNGITIPVVRLQGPIVSGGGPFRPALNLANVAPVLEKAFAMKDAPAVAITINSPGGSPVQSRLIFTR
IRELAREKQKKVLVFVEDVAASGGYMIALAGDEIIADSTSIVGSIGVVSGGFGFPELLKKIGVERRVYTAGENKVILDPF
QPEKEKDIEYLKSLQLEIHQVFISMVRERRAGKLRDDAAVFSGLFWSGTRGLELGLVDGLGDMRQELKRRYGQKTKLELV
AAGRGLFGRRVPGVSPVSLESAASGLATGLVEAAEERALWSRFGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=195, Percent_Identity=32.8205128205128, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31015; Mature: 30883

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFWRKLLPKRFRKNGITIPVVRLQGPIVSGGGPFRPALNLANVAPVLEKAFAMKDAPA
CCCHHHHHHHHHHHHCCCEEEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VAITINSPGGSPVQSRLIFTRIRELAREKQKKVLVFVEDVAASGGYMIALAGDEIIADST
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCEECCCH
SIVGSIGVVSGGFGFPELLKKIGVERRVYTAGENKVILDPFQPEKEKDIEYLKSLQLEIH
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHH
QVFISMVRERRAGKLRDDAAVFSGLFWSGTRGLELGLVDGLGDMRQELKRRYGQKTKLEL
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEE
VAAGRGLFGRRVPGVSPVSLESAASGLATGLVEAAEERALWSRFGL
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGFWRKLLPKRFRKNGITIPVVRLQGPIVSGGGPFRPALNLANVAPVLEKAFAMKDAPA
CCHHHHHHHHHHHHCCCEEEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VAITINSPGGSPVQSRLIFTRIRELAREKQKKVLVFVEDVAASGGYMIALAGDEIIADST
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCEECCCH
SIVGSIGVVSGGFGFPELLKKIGVERRVYTAGENKVILDPFQPEKEKDIEYLKSLQLEIH
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHH
QVFISMVRERRAGKLRDDAAVFSGLFWSGTRGLELGLVDGLGDMRQELKRRYGQKTKLEL
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEE
VAAGRGLFGRRVPGVSPVSLESAASGLATGLVEAAEERALWSRFGL
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA