Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 209548054

GI number: 209548054

Start: 458201

End: 459214

Strand: Reverse

Name: qor [C]

Synonym: Rleg2_0447

Alternate gene names: 209548054

Gene position: 459214-458201 (Counterclockwise)

Preceding gene: 209548056

Following gene: 209548051

Centisome position: 10.12

GC content: 62.33

Gene sequence:

>1014_bases
ATGTCGAGACAATCAACGATGAAAGTGATGTTGGCGGAATCGCCGAATTCGCCATTGCGGATCGCCGATGTTTCAAAGCC
TGTGCCGGGTGAAGGCCAGGTCCTGGTGCGTATCTTGGCGAGCGGTGTCAATCCGCTCGACCTCAAGATCAGAGCCGGCA
ATGCCGCCCATGCGCGCCACCCGCTTCCGGCCGTGCTTGGCATCGATATGGCCGGCATCGTGGAAGAGATCGGACCTGGC
GTCGGCGGTTTTCGTCGGGGCGACGCGGTCTATGGCATGACCGGTGGCGTTGGCGGCGTTCAGGGATCGCTTGCCGAATT
CGCAGCCGTCGACGCCGCACTGTTGGCTCCGAAGCCGCAGAACCTTTCTATGCGCGAGGCCGCAGCATTGCCGCTGATCG
CAATTACCGCCTGGGAAGGGCTCGTCGACCGCGCCGGCGTGAGAGCCGATCACAAGGTGCTCGTGCTCGGCGGTGGCGGT
GTCGGTCATATCGTCGCGCAGATCGCCAAGGCCGTCGGGGCGGAGGTCTATGTCGTCGATGGCGCTTCGAAAGTGGACTA
TCTCGCCGGTCTTGGTGCAACGCCGATCGATCGTGCCGCAGAGACGGTGGAAACCTATGTCGCCAGATATACCGGTGGCA
AGGGTTTCGATCTGATCTACGATACGGTCGGCGGCCAGGGGCTCGATACTGCGTTCCGGGCCGTCAGCCGGTTCGGCCAT
GTCGTGAGCTGCCTTGGCTGGGGAAATCACGCGCTGGCGCCGCTCTCCTTTAAGGCGGCGACCTATTCCGGGGTTTTCAC
GCTGCTGCCGCTTCTGAGCGGCGAAGGACGCCCACATCACGGCGAGATTATGCGGGAAATGACGAAACTGGTCGAGGCCG
GCGAGGTGATGCCGAGGCTCGACCCGCACCGCTTCACATTTGACGATACCGACGAGGCATATCTGCTGATCGAAAACCGG
CAGGCGGACGGGAAAGTCGTCGTCGAGATCGACCGATCTCACCTCGCCGAATGA

Upstream 100 bases:

>100_bases
TCCTTTTCTTCTATTTTCATTCGCGTTTCAATGAGCGATCTTTCTTCCGGAAAAGCCCGTTGCCACCGTAGACGCTGCAC
TGCGAACGAAGGAGAGTTGC

Downstream 100 bases:

>100_bases
CTGGAACAGGATGATTTGAGGCCCCGGTCGGCCTTAAATCTAATCCTTTGCTAAATCAGAGAGTGGCGCGTGATGTCGTC
TGAAAACACTCACATTTTTC

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSRQSTMKVMLAESPNSPLRIADVSKPVPGEGQVLVRILASGVNPLDLKIRAGNAAHARHPLPAVLGIDMAGIVEEIGPG
VGGFRRGDAVYGMTGGVGGVQGSLAEFAAVDAALLAPKPQNLSMREAAALPLIAITAWEGLVDRAGVRADHKVLVLGGGG
VGHIVAQIAKAVGAEVYVVDGASKVDYLAGLGATPIDRAAETVETYVARYTGGKGFDLIYDTVGGQGLDTAFRAVSRFGH
VVSCLGWGNHALAPLSFKAATYSGVFTLLPLLSGEGRPHHGEIMREMTKLVEAGEVMPRLDPHRFTFDDTDEAYLLIENR
QADGKVVVEIDRSHLAE

Sequences:

>Translated_337_residues
MSRQSTMKVMLAESPNSPLRIADVSKPVPGEGQVLVRILASGVNPLDLKIRAGNAAHARHPLPAVLGIDMAGIVEEIGPG
VGGFRRGDAVYGMTGGVGGVQGSLAEFAAVDAALLAPKPQNLSMREAAALPLIAITAWEGLVDRAGVRADHKVLVLGGGG
VGHIVAQIAKAVGAEVYVVDGASKVDYLAGLGATPIDRAAETVETYVARYTGGKGFDLIYDTVGGQGLDTAFRAVSRFGH
VVSCLGWGNHALAPLSFKAATYSGVFTLLPLLSGEGRPHHGEIMREMTKLVEAGEVMPRLDPHRFTFDDTDEAYLLIENR
QADGKVVVEIDRSHLAE
>Mature_336_residues
SRQSTMKVMLAESPNSPLRIADVSKPVPGEGQVLVRILASGVNPLDLKIRAGNAAHARHPLPAVLGIDMAGIVEEIGPGV
GGFRRGDAVYGMTGGVGGVQGSLAEFAAVDAALLAPKPQNLSMREAAALPLIAITAWEGLVDRAGVRADHKVLVLGGGGV
GHIVAQIAKAVGAEVYVVDGASKVDYLAGLGATPIDRAAETVETYVARYTGGKGFDLIYDTVGGQGLDTAFRAVSRFGHV
VSCLGWGNHALAPLSFKAATYSGVFTLLPLLSGEGRPHHGEIMREMTKLVEAGEVMPRLDPHRFTFDDTDEAYLLIENRQ
ADGKVVVEIDRSHLAE

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=341, Percent_Identity=28.7390029325513, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239674, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13236495, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538446, Length=341, Percent_Identity=28.1524926686217, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI22538444, Length=341, Percent_Identity=28.1524926686217, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI194239676, Length=157, Percent_Identity=35.031847133758, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI24308257, Length=340, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI18379349, Length=318, Percent_Identity=27.6729559748428, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI41872631, Length=238, Percent_Identity=30.2521008403361, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI28557745, Length=228, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790485, Length=303, Percent_Identity=28.3828382838284, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=384, Percent_Identity=26.5625, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17507255, Length=236, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=321, Percent_Identity=25.5451713395639, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45550423, Length=297, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35314; Mature: 35183

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQSTMKVMLAESPNSPLRIADVSKPVPGEGQVLVRILASGVNPLDLKIRAGNAAHARH
CCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCC
PLPAVLGIDMAGIVEEIGPGVGGFRRGDAVYGMTGGVGGVQGSLAEFAAVDAALLAPKPQ
CCCHHHHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
NLSMREAAALPLIAITAWEGLVDRAGVRADHKVLVLGGGGVGHIVAQIAKAVGAEVYVVD
CCCHHHHHCCCEEEEEHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEC
GASKVDYLAGLGATPIDRAAETVETYVARYTGGKGFDLIYDTVGGQGLDTAFRAVSRFGH
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
VVSCLGWGNHALAPLSFKAATYSGVFTLLPLLSGEGRPHHGEIMREMTKLVEAGEVMPRL
HHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DPHRFTFDDTDEAYLLIENRQADGKVVVEIDRSHLAE
CCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHHCCC
>Mature Secondary Structure 
SRQSTMKVMLAESPNSPLRIADVSKPVPGEGQVLVRILASGVNPLDLKIRAGNAAHARH
CCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCC
PLPAVLGIDMAGIVEEIGPGVGGFRRGDAVYGMTGGVGGVQGSLAEFAAVDAALLAPKPQ
CCCHHHHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
NLSMREAAALPLIAITAWEGLVDRAGVRADHKVLVLGGGGVGHIVAQIAKAVGAEVYVVD
CCCHHHHHCCCEEEEEHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEC
GASKVDYLAGLGATPIDRAAETVETYVARYTGGKGFDLIYDTVGGQGLDTAFRAVSRFGH
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
VVSCLGWGNHALAPLSFKAATYSGVFTLLPLLSGEGRPHHGEIMREMTKLVEAGEVMPRL
HHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
DPHRFTFDDTDEAYLLIENRQADGKVVVEIDRSHLAE
CCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]