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The map label for this gene is guaB [H]

Identifier: 209548039

GI number: 209548039

Start: 443359

End: 444843

Strand: Direct

Name: guaB [H]

Synonym: Rleg2_0432

Alternate gene names: 209548039

Gene position: 443359-444843 (Clockwise)

Preceding gene: 209548038

Following gene: 209548040

Centisome position: 9.77

GC content: 65.39

Gene sequence:

>1485_bases
ATGGCACGTATCATTGAAACGGCAACCGGCGCGGACGCGCTTACCTTCGACGACGTGCTGCTGCAGCCCGGCCACTCCGA
GGTCATGCCCGGCCAGACGAATATCGCGACCCGCATCGCCCGGGACTTCGAGCTCAACATCCCGATCCTGTCTTCGGCCA
TGGATACCGTCACCGAAAGCCGTCTGGCGATCGCCATGGCCCAGGCCGGCGGCCTCGGCGTCATCCACCGCAACCTGACG
CCGGTCGAGCAGGCCGAAGAAGTCCGCCAGGTGAAGAAGTTCGAAAGCGGCATGGTCGTCAACCCGGTCACCATCGGTCC
GGAGGCAAAGCTTGCCGAAGCACTCGGCCTGATGAAATCACACGGCATTTCCGGTATCCCGGTCGTCGAGAAGTCGGGCC
GCCTCGTCGGCATCCTGACCAACCGGGACGTGCGCTTCGCCTCCGATCCGGAGCAGAAGATCCACGAGCTGATGACCAAG
GACAATCTGGTCACCGTCAAGGAGAGCGTCGATCAGCAGGAGGCCAAGCGCCTGCTGCATTCGCACCGGATCGAGAAGCT
GCTGGTCGTCGATACCGAAGGCCGCTGCGTCGGCCTCATCACCGTCAAGGACATCGAGAAGTCGCAGCTGAACCCGAACG
CCTCCAAGGATGCGCAGGGCAGGCTTCGCGCCGCCGCTGCCATCAGCGTCGGCGATGACGGCTTCGAGCGCGCCGAACGG
CTGATCGAGGCCGGCGTCGACCTCTTGGTCGTCGATACCGCCCATGGCCATTCGCAGCGCGTGCTCGACGCGGTTACCCG
CGTCAAGAAGCTGTCCAACTCGGTGCGCATCATGGCCGGCAATGTCGCCACCTATGACGGTACGCGAGCGCTGATCGATG
CGGGTGCGGATGCTGTCAAGGTCGGCATCGGCCCGGGCTCGATCTGCACGACGCGCATCGTCGCCGGCGTCGGCGTTCCC
CAGCTTGCCGCCATCATGTCGGCGGTTCAGGCAGCCCAGGCTCAGGACGTGCCCGTCATCGCCGATGGCGGCATCAAATT
TTCCGGCGATCTTGCCAAGGCGATCGCCGCCGGCGCTTCCGCCGTCATGATCGGCTCGCTGCTGGCCGGCACCGATGAGA
GCCCGGGCGAGGTCTATCTCTACCAGGGCCGTTCCTTCAAAGCCTATCGCGGCATGGGCTCCGTCGGCGCCATGGCCCGC
GGTTCCGCCGACCGTTATTTCCAGGCTGAGGTGCGCGACACGCTGAAGCTCGTGCCGGAGGGTATCGAAGGTCAGGTTCC
CTACAAGGGACCGGTCTCGGCCGTCGTCCACCAGCTCGCCGGCGGCCTCAAGGCGGCCATGGGTTATGTCGGCGGCAAGG
ACCTGAAGGATTTCCAGGAGCGGGCGACCTTCGTGCGCATCTCCGGCGCCGGCCTTCGCGAAAGCCATGCCCATGATGTG
ACGATCACCCGCGAGAGCCCGAACTATCCGGGCGCCGGCCTCTGA

Upstream 100 bases:

>100_bases
ACCAGCCCTCGCCAACTTCCAAGCAATCCCATGCACACCGCCGGGGCGGACGATTCGTTTCCGGGCCAGGTTGCATTTTC
TTAAATGAAGGAATTTGGCC

Downstream 100 bases:

>100_bases
TCATGAAGGCGGGCAGCGGGATTCCCCTTTGGACCGTCGCGCTGCTCGCAGCCCTCTGCCTTGCCGTGCTCGCCTGGACG
ACCTTCGGCTTCGTCGTGCC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MARIIETATGADALTFDDVLLQPGHSEVMPGQTNIATRIARDFELNIPILSSAMDTVTESRLAIAMAQAGGLGVIHRNLT
PVEQAEEVRQVKKFESGMVVNPVTIGPEAKLAEALGLMKSHGISGIPVVEKSGRLVGILTNRDVRFASDPEQKIHELMTK
DNLVTVKESVDQQEAKRLLHSHRIEKLLVVDTEGRCVGLITVKDIEKSQLNPNASKDAQGRLRAAAAISVGDDGFERAER
LIEAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRIVAGVGVP
QLAAIMSAVQAAQAQDVPVIADGGIKFSGDLAKAIAAGASAVMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMAR
GSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSAVVHQLAGGLKAAMGYVGGKDLKDFQERATFVRISGAGLRESHAHDV
TITRESPNYPGAGL

Sequences:

>Translated_494_residues
MARIIETATGADALTFDDVLLQPGHSEVMPGQTNIATRIARDFELNIPILSSAMDTVTESRLAIAMAQAGGLGVIHRNLT
PVEQAEEVRQVKKFESGMVVNPVTIGPEAKLAEALGLMKSHGISGIPVVEKSGRLVGILTNRDVRFASDPEQKIHELMTK
DNLVTVKESVDQQEAKRLLHSHRIEKLLVVDTEGRCVGLITVKDIEKSQLNPNASKDAQGRLRAAAAISVGDDGFERAER
LIEAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRIVAGVGVP
QLAAIMSAVQAAQAQDVPVIADGGIKFSGDLAKAIAAGASAVMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMAR
GSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSAVVHQLAGGLKAAMGYVGGKDLKDFQERATFVRISGAGLRESHAHDV
TITRESPNYPGAGL
>Mature_493_residues
ARIIETATGADALTFDDVLLQPGHSEVMPGQTNIATRIARDFELNIPILSSAMDTVTESRLAIAMAQAGGLGVIHRNLTP
VEQAEEVRQVKKFESGMVVNPVTIGPEAKLAEALGLMKSHGISGIPVVEKSGRLVGILTNRDVRFASDPEQKIHELMTKD
NLVTVKESVDQQEAKRLLHSHRIEKLLVVDTEGRCVGLITVKDIEKSQLNPNASKDAQGRLRAAAAISVGDDGFERAERL
IEAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQ
LAAIMSAVQAAQAQDVPVIADGGIKFSGDLAKAIAAGASAVMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMARG
SADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSAVVHQLAGGLKAAMGYVGGKDLKDFQERATFVRISGAGLRESHAHDVT
ITRESPNYPGAGL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=487, Percent_Identity=37.5770020533881, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI217035146, Length=488, Percent_Identity=37.2950819672131, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI34328928, Length=488, Percent_Identity=37.2950819672131, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI156616279, Length=488, Percent_Identity=37.2950819672131, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI34328930, Length=488, Percent_Identity=37.2950819672131, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI217035152, Length=481, Percent_Identity=37.006237006237, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI217035148, Length=488, Percent_Identity=36.4754098360656, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI217035150, Length=488, Percent_Identity=34.2213114754098, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=40.650406504065, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=40.650406504065, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=40.650406504065, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=40.650406504065, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI156104880, Length=240, Percent_Identity=39.1666666666667, Blast_Score=165, Evalue=8e-41,
Organism=Escherichia coli, GI1788855, Length=479, Percent_Identity=56.3674321503132, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=259, Percent_Identity=37.0656370656371, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=473, Percent_Identity=34.8837209302326, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=35.9338061465721, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=289, Percent_Identity=37.7162629757785, Blast_Score=175, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=452, Percent_Identity=38.2743362831858, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=38.8646288209607, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=458, Percent_Identity=39.3013100436681, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=37.0919881305638, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=42.7350427350427, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=464, Percent_Identity=37.2844827586207, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24641073, Length=464, Percent_Identity=37.2844827586207, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI28571163, Length=416, Percent_Identity=38.9423076923077, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52059; Mature: 51928

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIIETATGADALTFDDVLLQPGHSEVMPGQTNIATRIARDFELNIPILSSAMDTVTES
CCCEEECCCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHHHHCEECCCCHHHHHHHHHHHH
RLAIAMAQAGGLGVIHRNLTPVEQAEEVRQVKKFESGMVVNPVTIGPEAKLAEALGLMKS
HHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHH
HGISGIPVVEKSGRLVGILTNRDVRFASDPEQKIHELMTKDNLVTVKESVDQQEAKRLLH
CCCCCCCEEECCCCEEEEEECCCEEECCCHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHH
SHRIEKLLVVDTEGRCVGLITVKDIEKSQLNPNASKDAQGRLRAAAAISVGDDGFERAER
HHCCCEEEEEECCCCEEEEEEEECCHHHCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHH
LIEAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHHHHCCCCEEE
VGIGPGSICTTRIVAGVGVPQLAAIMSAVQAAQAQDVPVIADGGIKFSGDLAKAIAAGAS
EECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCH
AVMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCC
GIEGQVPYKGPVSAVVHQLAGGLKAAMGYVGGKDLKDFQERATFVRISGAGLRESHAHDV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCCCEE
TITRESPNYPGAGL
EEEECCCCCCCCCC
>Mature Secondary Structure 
ARIIETATGADALTFDDVLLQPGHSEVMPGQTNIATRIARDFELNIPILSSAMDTVTES
CCEEECCCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHHHHCEECCCCHHHHHHHHHHHH
RLAIAMAQAGGLGVIHRNLTPVEQAEEVRQVKKFESGMVVNPVTIGPEAKLAEALGLMKS
HHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCHHHHHHHHHHHH
HGISGIPVVEKSGRLVGILTNRDVRFASDPEQKIHELMTKDNLVTVKESVDQQEAKRLLH
CCCCCCCEEECCCCEEEEEECCCEEECCCHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHH
SHRIEKLLVVDTEGRCVGLITVKDIEKSQLNPNASKDAQGRLRAAAAISVGDDGFERAER
HHCCCEEEEEECCCCEEEEEEEECCHHHCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHH
LIEAGVDLLVVDTAHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHHHHCCCCEEE
VGIGPGSICTTRIVAGVGVPQLAAIMSAVQAAQAQDVPVIADGGIKFSGDLAKAIAAGAS
EECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCH
AVMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCC
GIEGQVPYKGPVSAVVHQLAGGLKAAMGYVGGKDLKDFQERATFVRISGAGLRESHAHDV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCCCEE
TITRESPNYPGAGL
EEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA