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The map label for this gene is rmlA1 [H]

Identifier: 209548011

GI number: 209548011

Start: 415604

End: 416515

Strand: Direct

Name: rmlA1 [H]

Synonym: Rleg2_0403

Alternate gene names: 209548011

Gene position: 415604-416515 (Clockwise)

Preceding gene: 209548009

Following gene: 209548012

Centisome position: 9.16

GC content: 56.36

Gene sequence:

>912_bases
TTGTCTTCGAAGAAAAAGCTGCGCAAGGGCATCTTGCTCGCCGGGGGCTCGGGTACCCGTCTCCATCCCGCGACCCTCGC
CATTTCGAAGCAACTCCTTCCGGTTTTTGACAAACCGATGATCTACTATCCCCTGTCAACGCTGATGCTTGCGGGTATCC
GGGATATCCTGATTATCTCTACGCCGCAGGACACGCCGCGCTTTGAACAGCTACTGGGTGACGGCGCCCAATGGGGATTG
AACCTTCAATATGCCGTGCAGGCCGCGCCGGACGGAATTCCCCAGGCGTTCTCGATCGGCAGGGAATTCATCGGGCAAGA
GGCAACTGCCCTCGTGCTCGGAGACAATATCTTTTATGGCAACCTCCTGACGCATGATTTGTCCGCGGCTTCGGCGAGAT
CGGACGAAGCGACGATCTTCGCGTATAAAGTCCACGATCCCGAGCGCTATGGGGTAGTGGAATTTGACGGTCAGGGCAAA
GTCCTCACCTTGGAGGAAAAGCCGTCCAGGCCCCGCTCGTCTTACGCGGTGACGGGTCTATATTTCTACGACAATGAGGT
GATTGACATTGCTGCCGGTTTGAAACCCTCGCCGCGCGGTGAAACCGAAATAACCGACATCAATCGGCATTATTTGTCGG
CCGGCAGGCTGAATGTTGCCGTGCTGGGAAGAGGGCATGCCTGGCTTGATACGGGCACGCACGATTCACTCCTTGAAGCC
AGTCAGTTCATTGCCACCATCGAGCGGCGCCAGGGGCTGAAGATTGCCTGCCCCGAAGAAATCGCCTTTCATTTGGAATA
CATCGATGCCGAGCAATTGCTAAGGTTGGCGGCTCCACTTGAAAAGAGCTCTTACGGTCGATACCTCATCAGCCTGGTGA
GGGAGCCAGCTCCGCATTTCCCAACCGGCTGA

Upstream 100 bases:

>100_bases
TTGCATGCCGATCGATCTATCTGTAGTGAGCAATGTCGAACAGCGACGTCATCACGAAGCCTTGTGAATGCGCGCGGATT
TACCAGTTGCAGGAGGTCTC

Downstream 100 bases:

>100_bases
ACCGGCAAAACTGGAAAACCAATCTTGTCTGCTTTTACCCTGCTTACGTTAAAGACGATGTCCGACGGACGAGGCGCGCT
GACCGTCATGGACGGAATAC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSSKKKLRKGILLAGGSGTRLHPATLAISKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGAQWGL
NLQYAVQAAPDGIPQAFSIGREFIGQEATALVLGDNIFYGNLLTHDLSAASARSDEATIFAYKVHDPERYGVVEFDGQGK
VLTLEEKPSRPRSSYAVTGLYFYDNEVIDIAAGLKPSPRGETEITDINRHYLSAGRLNVAVLGRGHAWLDTGTHDSLLEA
SQFIATIERRQGLKIACPEEIAFHLEYIDAEQLLRLAAPLEKSSYGRYLISLVREPAPHFPTG

Sequences:

>Translated_303_residues
MSSKKKLRKGILLAGGSGTRLHPATLAISKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGAQWGL
NLQYAVQAAPDGIPQAFSIGREFIGQEATALVLGDNIFYGNLLTHDLSAASARSDEATIFAYKVHDPERYGVVEFDGQGK
VLTLEEKPSRPRSSYAVTGLYFYDNEVIDIAAGLKPSPRGETEITDINRHYLSAGRLNVAVLGRGHAWLDTGTHDSLLEA
SQFIATIERRQGLKIACPEEIAFHLEYIDAEQLLRLAAPLEKSSYGRYLISLVREPAPHFPTG
>Mature_302_residues
SSKKKLRKGILLAGGSGTRLHPATLAISKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGAQWGLN
LQYAVQAAPDGIPQAFSIGREFIGQEATALVLGDNIFYGNLLTHDLSAASARSDEATIFAYKVHDPERYGVVEFDGQGKV
LTLEEKPSRPRSSYAVTGLYFYDNEVIDIAAGLKPSPRGETEITDINRHYLSAGRLNVAVLGRGHAWLDTGTHDSLLEAS
QFIATIERRQGLKIACPEEIAFHLEYIDAEQLLRLAAPLEKSSYGRYLISLVREPAPHFPTG

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=70, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=60.1398601398601, Blast_Score=366, Evalue=1e-103,
Organism=Escherichia coli, GI1787488, Length=297, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=191, Percent_Identity=28.2722513089005, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=258, Percent_Identity=25.968992248062, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=22.7091633466135, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=22.7091633466135, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33293; Mature: 33162

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKKKLRKGILLAGGSGTRLHPATLAISKQLLPVFDKPMIYYPLSTLMLAGIRDILIIS
CCCHHHHHCCEEEECCCCCEECHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCEEEEEE
TPQDTPRFEQLLGDGAQWGLNLQYAVQAAPDGIPQAFSIGREFIGQEATALVLGDNIFYG
CCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCEEEC
NLLTHDLSAASARSDEATIFAYKVHDPERYGVVEFDGQGKVLTLEEKPSRPRSSYAVTGL
CHHHHCCHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEE
YFYDNEVIDIAAGLKPSPRGETEITDINRHYLSAGRLNVAVLGRGHAWLDTGTHDSLLEA
EEECCCEEEEECCCCCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCEEECCCCCHHHHHH
SQFIATIERRQGLKIACPEEIAFHLEYIDAEQLLRLAAPLEKSSYGRYLISLVREPAPHF
HHHHHHHHHHCCCEEECHHHHEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
PTG
CCC
>Mature Secondary Structure 
SSKKKLRKGILLAGGSGTRLHPATLAISKQLLPVFDKPMIYYPLSTLMLAGIRDILIIS
CCHHHHHCCEEEECCCCCEECHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCEEEEEE
TPQDTPRFEQLLGDGAQWGLNLQYAVQAAPDGIPQAFSIGREFIGQEATALVLGDNIFYG
CCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCEEEC
NLLTHDLSAASARSDEATIFAYKVHDPERYGVVEFDGQGKVLTLEEKPSRPRSSYAVTGL
CHHHHCCHHHCCCCCCEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEE
YFYDNEVIDIAAGLKPSPRGETEITDINRHYLSAGRLNVAVLGRGHAWLDTGTHDSLLEA
EEECCCEEEEECCCCCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCEEECCCCCHHHHHH
SQFIATIERRQGLKIACPEEIAFHLEYIDAEQLLRLAAPLEKSSYGRYLISLVREPAPHF
HHHHHHHHHHCCCEEECHHHHEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
PTG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]