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The map label for this gene is hisD [H]

Identifier: 209547848

GI number: 209547848

Start: 244671

End: 245969

Strand: Direct

Name: hisD [H]

Synonym: Rleg2_0239

Alternate gene names: 209547848

Gene position: 244671-245969 (Clockwise)

Preceding gene: 209547847

Following gene: 209547849

Centisome position: 5.39

GC content: 64.74

Gene sequence:

>1299_bases
TTGGCAATCTGGCTGGATCAGGCATCGGAAGGTTTCGAGCAGCGTTTTGCCACCTTTCTGACGACGAAGCGTGAAGTCTC
CGAGGATGTGAACACCGTCGTTCGCGCCATCATCGATGATGTCAGGGCCCGCGGCGATGTGGCGCTTGCCGAATATTCGT
TGAAGTTCGACGGCATCGATTTCGCCACCGTGCCGATGCGCGTCACGCCTGAGGAGTTCGACGCCGCGATCGAGGCCGTG
CCTCCGGAAGTGCTGGGTGCGCTGAAGCTCGCAGCACTGCGCATTGAATCCCATCATCGCCGGCAGCTGCCGAAGGACGA
TATTTATGAGGACGACATGGGCGTCGGCCTCGGCTCGCGCTGGACGGCGATCGAGGCGGTCGGGCTCTATGTTCCGGGCG
GCACCGCGAGTTATCCGAGCTCGGTGCTGATGAATGCCGTGCCGGCCAAGGTTGCAGGCGTCGATCGCATCGTCATCGCC
GTTCCCGCCACCGGCGGTGCCGTCAATCCGGCGGTGCTTGCCGCCGCCAGGCTTGTCGGTGTGACCGAGGTTTATCGTGT
CGGCGGCGCCCAGGCGATCGCGGCTCTTGCCTATGGCACCGAGACGATCGCCCCGGTTGCCAAGATCACCGGTCCCGGCA
ATGCCTATGTCGCAGCCGCCAAGCGCCATGTCTTCGGCACTGTCGGCATCGATATGATCGCCGGCCCTTCCGAAGTGCTC
GTCATCGCCGACAAGGACAACAATCCCGATTGGATCGCCGCCGACCTGCTGGCGCAGGCCGAGCACGATGCCAGCGCCCA
GGCGATCCTGATCACCGACGATGCCGAATTCGGCAAGGCGGTGGAGCAGGCGGTCGAGCGCCAGCTGAAGACGCTGAACC
GTGCCGAGACCGCCGCGGCAAGCTGGCGCGATTTCGGCGCGGTCATTCTCGTTGCCGATCTGAAGCAGGCCATTCCGCTT
GCCAACCGCATCGCCGCCGAGCATCTGGAGCTTGCCGTCGCCGATCCGGATCGGCTGCTCGACGGCATCCGCAATGCCGG
CGCGATCTTCATCGGCGCTCATACGCCCGAGGTGATCGGCGATTATGTCGGCGGGTCCAACCACGTGCTGCCGACGGCGC
GCTCGGCGCGTTTCTCCTCCGGCCTTTCGGTGCTCGATTTCGTCAAGCGCACCTCGATCCTGCGGCTCGGCCCGCAGCAA
TTGCGCACCCTCGGCCCGGCGGCGATTGCTCTAGCCGTCTCCGAAGGCCTCGATGCTCATGCGCGATCGGTTGCGATCCG
CCTCAACCTCGAAAGGTGA

Upstream 100 bases:

>100_bases
GCCTGGGAGGCCTCCTCCAAGCCTCGCCACCTCTGACGTCGCTGACGCAGGCGCTTGAGGTTTGAACATCGCAGTTTCGA
GTTGAGAAGGAATATCGGCC

Downstream 100 bases:

>100_bases
GGGGATGGCGGCGGGCGATTTCCGGCTTTGCGACGTCGTCCTCGACGATACGATCGGCCGTTCGACGCCCGATGTCGAGC
ATGAGCGCGCCGTCGCCATC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MAIWLDQASEGFEQRFATFLTTKREVSEDVNTVVRAIIDDVRARGDVALAEYSLKFDGIDFATVPMRVTPEEFDAAIEAV
PPEVLGALKLAALRIESHHRRQLPKDDIYEDDMGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVDRIVIA
VPATGGAVNPAVLAAARLVGVTEVYRVGGAQAIAALAYGTETIAPVAKITGPGNAYVAAAKRHVFGTVGIDMIAGPSEVL
VIADKDNNPDWIAADLLAQAEHDASAQAILITDDAEFGKAVEQAVERQLKTLNRAETAAASWRDFGAVILVADLKQAIPL
ANRIAAEHLELAVADPDRLLDGIRNAGAIFIGAHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPQQ
LRTLGPAAIALAVSEGLDAHARSVAIRLNLER

Sequences:

>Translated_432_residues
MAIWLDQASEGFEQRFATFLTTKREVSEDVNTVVRAIIDDVRARGDVALAEYSLKFDGIDFATVPMRVTPEEFDAAIEAV
PPEVLGALKLAALRIESHHRRQLPKDDIYEDDMGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVDRIVIA
VPATGGAVNPAVLAAARLVGVTEVYRVGGAQAIAALAYGTETIAPVAKITGPGNAYVAAAKRHVFGTVGIDMIAGPSEVL
VIADKDNNPDWIAADLLAQAEHDASAQAILITDDAEFGKAVEQAVERQLKTLNRAETAAASWRDFGAVILVADLKQAIPL
ANRIAAEHLELAVADPDRLLDGIRNAGAIFIGAHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPQQ
LRTLGPAAIALAVSEGLDAHARSVAIRLNLER
>Mature_431_residues
AIWLDQASEGFEQRFATFLTTKREVSEDVNTVVRAIIDDVRARGDVALAEYSLKFDGIDFATVPMRVTPEEFDAAIEAVP
PEVLGALKLAALRIESHHRRQLPKDDIYEDDMGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVDRIVIAV
PATGGAVNPAVLAAARLVGVTEVYRVGGAQAIAALAYGTETIAPVAKITGPGNAYVAAAKRHVFGTVGIDMIAGPSEVLV
IADKDNNPDWIAADLLAQAEHDASAQAILITDDAEFGKAVEQAVERQLKTLNRAETAAASWRDFGAVILVADLKQAIPLA
NRIAAEHLELAVADPDRLLDGIRNAGAIFIGAHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPQQL
RTLGPAAIALAVSEGLDAHARSVAIRLNLER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=429, Percent_Identity=41.958041958042, Blast_Score=297, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=40.5797101449275, Blast_Score=275, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45606; Mature: 45475

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIWLDQASEGFEQRFATFLTTKREVSEDVNTVVRAIIDDVRARGDVALAEYSLKFDGID
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
FATVPMRVTPEEFDAAIEAVPPEVLGALKLAALRIESHHRRQLPKDDIYEDDMGVGLGSR
EEEECEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLVG
CEEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VTEVYRVGGAQAIAALAYGTETIAPVAKITGPGNAYVAAAKRHVFGTVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHHCCHHHCCHHEECCCCCEEEEEHHHHEEEECCCEEECCCCEEE
VIADKDNNPDWIAADLLAQAEHDASAQAILITDDAEFGKAVEQAVERQLKTLNRAETAAA
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SWRDFGAVILVADLKQAIPLANRIAAEHLELAVADPDRLLDGIRNAGAIFIGAHTPEVIG
HHHHCCCEEEEEHHHHHCCHHHHHHHHHHEEEECCHHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPQQLRTLGPAAIALAVSEGLDAH
HHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCC
ARSVAIRLNLER
CEEEEEEEEECC
>Mature Secondary Structure 
AIWLDQASEGFEQRFATFLTTKREVSEDVNTVVRAIIDDVRARGDVALAEYSLKFDGID
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCC
FATVPMRVTPEEFDAAIEAVPPEVLGALKLAALRIESHHRRQLPKDDIYEDDMGVGLGSR
EEEECEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLVG
CEEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VTEVYRVGGAQAIAALAYGTETIAPVAKITGPGNAYVAAAKRHVFGTVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHHCCHHHCCHHEECCCCCEEEEEHHHHEEEECCCEEECCCCEEE
VIADKDNNPDWIAADLLAQAEHDASAQAILITDDAEFGKAVEQAVERQLKTLNRAETAAA
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SWRDFGAVILVADLKQAIPLANRIAAEHLELAVADPDRLLDGIRNAGAIFIGAHTPEVIG
HHHHCCCEEEEEHHHHHCCHHHHHHHHHHEEEECCHHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPQQLRTLGPAAIALAVSEGLDAH
HHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCC
ARSVAIRLNLER
CEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]