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The map label for this gene is pyrD [H]

Identifier: 209547802

GI number: 209547802

Start: 192166

End: 193254

Strand: Direct

Name: pyrD [H]

Synonym: Rleg2_0193

Alternate gene names: 209547802

Gene position: 192166-193254 (Clockwise)

Preceding gene: 209547801

Following gene: 209547806

Centisome position: 4.23

GC content: 66.12

Gene sequence:

>1089_bases
ATGATCGATCCTTTCAAGCGTCTCGCCCGCAAGGGTCTCTTCCTCTTCGATCCGGAAACGGCGCACGGCATGTCGATCGC
CGCGCTGAAATCCGGCCTGGTGCCCGCCTGCCAGATCACGCCCGATCCGCGCCTGTGCCAGACCGTTGCCGGCCTCACCT
TCGAAAACCCGCTCGGCATGGCGGCAGGCTATGACAAGAATGCCGAGGTGCCGGAGGCGCTGCTGAAGCTCGGTTTCGGC
TTTACCGAGATCGGCACGGTGACGCCGAAGCCGCAAGCCGGCAATCCGCGGCCGCGCATCTTCCGCCTGGTCGAGGATGA
GGCGGTCATCAACCGCCTCGGCTTCAACAATGAAGGCCATGAGGCCGCTTTCGGGCGCCTCGCGGCGCTGAGCGGCAGGG
GCATCGTCGGCGTCAATATCGGTGCCAACAAGGACAGCGAGGATCGCATCGCCGACTACGTTGCCGGCATCCGCCGCTTC
CATTCGGTGGCGCGCTATTTCACCGCCAACATCTCCTCGCCGAACACGCCCGGCCTGCGTGACCTGCAGGCGCGTGAAAG
CCTGGCGGCGCTGCTGTCATCCGTGCTGGCGGCGCGCGACGAAGTGGCGGCGGCCTCGGGCCGCAAGGTCCCGGTCTTCC
TGAAGATCGCCCCCGACCTGACCGAGGAAGGCATGGACGATATCGCCGCGGAAGCGCTCGCGCATGCGCTGGATGGCTTG
ATCGTCTCCAACACCACGCTGTCGCGCGACGGCCTCAAGGATCAGCGCCAGGCGAAGGAGACGGGTGGCCTCTCCGGCGT
GCCGCTGTTCGAAAAGTCGACTGCGGTGCTTGCGAGAATGCGCAAACGTGTCGGTGCCGCGCTGCCGATCATCGGCGTCG
GCGGCGTCTCCTCGGCCGAAACGGCGCTGGAGAAGATCAGGGCGGGCGCCGACCTCGTCCAGCTCTATTCCTGCATGGTC
TATGAAGGCCCCGGTCTGCCCGGCGATATCGTCCGCGGCCTTTCCAAACTCATGGACCGCGAAAAGGCGGCCGGGATCGG
CGAGCTGCGCGACAGCAGGCTGGATTACTGGGCGGCGCGAAAAGTCTGA

Upstream 100 bases:

>100_bases
TCCCGCATCTCTATGCCGATCTGCCGCTTGAAGCCGTGCTCTGGGAAGCGCCGCTGCCGCTCGACCAGGCCGGCGCCCAT
ATTTTCCCGGAGCTGCAGCC

Downstream 100 bases:

>100_bases
TCGGCCCGCGGCTTGACCAGCAGCGCCAGGAAAAAGCCGCGGAAGAGCAGAAAGGCGTTCATAGCAAGCCACAGGCCGTG
ATTGCCGAAGAGCGGCACGA

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQITPDPRLCQTVAGLTFENPLGMAAGYDKNAEVPEALLKLGFG
FTEIGTVTPKPQAGNPRPRIFRLVEDEAVINRLGFNNEGHEAAFGRLAALSGRGIVGVNIGANKDSEDRIADYVAGIRRF
HSVARYFTANISSPNTPGLRDLQARESLAALLSSVLAARDEVAAASGRKVPVFLKIAPDLTEEGMDDIAAEALAHALDGL
IVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGAALPIIGVGGVSSAETALEKIRAGADLVQLYSCMV
YEGPGLPGDIVRGLSKLMDREKAAGIGELRDSRLDYWAARKV

Sequences:

>Translated_362_residues
MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQITPDPRLCQTVAGLTFENPLGMAAGYDKNAEVPEALLKLGFG
FTEIGTVTPKPQAGNPRPRIFRLVEDEAVINRLGFNNEGHEAAFGRLAALSGRGIVGVNIGANKDSEDRIADYVAGIRRF
HSVARYFTANISSPNTPGLRDLQARESLAALLSSVLAARDEVAAASGRKVPVFLKIAPDLTEEGMDDIAAEALAHALDGL
IVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGAALPIIGVGGVSSAETALEKIRAGADLVQLYSCMV
YEGPGLPGDIVRGLSKLMDREKAAGIGELRDSRLDYWAARKV
>Mature_362_residues
MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQITPDPRLCQTVAGLTFENPLGMAAGYDKNAEVPEALLKLGFG
FTEIGTVTPKPQAGNPRPRIFRLVEDEAVINRLGFNNEGHEAAFGRLAALSGRGIVGVNIGANKDSEDRIADYVAGIRRF
HSVARYFTANISSPNTPGLRDLQARESLAALLSSVLAARDEVAAASGRKVPVFLKIAPDLTEEGMDDIAAEALAHALDGL
IVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGAALPIIGVGGVSSAETALEKIRAGADLVQLYSCMV
YEGPGLPGDIVRGLSKLMDREKAAGIGELRDSRLDYWAARKV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=340, Percent_Identity=46.4705882352941, Blast_Score=279, Evalue=3e-75,
Organism=Escherichia coli, GI1787177, Length=344, Percent_Identity=44.7674418604651, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17509475, Length=345, Percent_Identity=42.8985507246377, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI281361352, Length=342, Percent_Identity=46.7836257309941, Blast_Score=304, Evalue=6e-83,
Organism=Drosophila melanogaster, GI17137316, Length=342, Percent_Identity=46.7836257309941, Blast_Score=304, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38517; Mature: 38517

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQITPDPRLCQTVAGLTFENPLGM
CCCHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCC
AAGYDKNAEVPEALLKLGFGFTEIGTVTPKPQAGNPRPRIFRLVEDEAVINRLGFNNEGH
CCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCC
EAAFGRLAALSGRGIVGVNIGANKDSEDRIADYVAGIRRFHSVARYFTANISSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DLQARESLAALLSSVLAARDEVAAASGRKVPVFLKIAPDLTEEGMDDIAAEALAHALDGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCE
IVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGAALPIIGVGGVSSAE
EEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALEKIRAGADLVQLYSCMVYEGPGLPGDIVRGLSKLMDREKAAGIGELRDSRLDYWAAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
KV
CC
>Mature Secondary Structure
MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQITPDPRLCQTVAGLTFENPLGM
CCCHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCCC
AAGYDKNAEVPEALLKLGFGFTEIGTVTPKPQAGNPRPRIFRLVEDEAVINRLGFNNEGH
CCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCC
EAAFGRLAALSGRGIVGVNIGANKDSEDRIADYVAGIRRFHSVARYFTANISSPNTPGLR
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DLQARESLAALLSSVLAARDEVAAASGRKVPVFLKIAPDLTEEGMDDIAAEALAHALDGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCE
IVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGAALPIIGVGGVSSAE
EEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALEKIRAGADLVQLYSCMVYEGPGLPGDIVRGLSKLMDREKAAGIGELRDSRLDYWAAR
HHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
KV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA