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The map label for this gene is phoR [H]

Identifier: 209547776

GI number: 209547776

Start: 165090

End: 166313

Strand: Direct

Name: phoR [H]

Synonym: Rleg2_0167

Alternate gene names: 209547776

Gene position: 165090-166313 (Clockwise)

Preceding gene: 209547774

Following gene: 209547777

Centisome position: 3.64

GC content: 64.54

Gene sequence:

>1224_bases
TTGGCGCGCATCCGGCGCGAGCGGCCTGTGCTGCTGGCGGCGATCCTCAGCGCGCTTGCCGCGCTTGCCGCCGGCATGAA
CAAGTGGGTTGTGCTTGGCCTCCTGCTGGTCATGATCGTCACCGCGCTTTTCAATGAGGCGCCCGTCATCAAGGACGAAC
CCGCCGAGCCGGTGGAGATTGCGCCGGAGGTGCCGCCAAGCCGCCTGCCTGAAGTGTCCGCCACACTCTCCGGCCTCGAT
ATCCCGGTCATGGTGCTGTCGGACGACGCCTCAGTGCTCTTCCAGAACCGGGCGGCCGAAAAGGCCTTCGGCGAGGTGGC
GCTCGGCGCCCATATATCGGCCCGCCTGCGCTCGCCCGGCGTGCTCGACATGGTGCGGGAAACCATCGCCACCAATGCGC
CGAACCAGATCGAGCATGCCGAGCGGCTGCCCTCCGAGCGCGTCTATATCGTCCGCAGCGCGCCCATCGAATTTTCGGCC
GAAGAGGGCGCGCGAGAGCGCTACTTCATCCTTTCCTTCCGCGATATATCAGAGGTCCGCCGCATCGACCGCATGCGGTC
GGATTTCGTCGCCAATGCCAGCCATGAGTTGCGCACGCCGCTTGCCTCGCTGCGCGGCTTCATCGAGACCATCCAAGGAC
CGGCGAAAAACGATCTCAAGGCGCAGGCGCGGTTCCTCGCCATCATGTTCGATCAGACGACGCGCATGAGCAGGCTGGTC
GACGACCTGCTGTCGCTGTCGCGGCTGGAGCTGAAATCGCACATCGCGCCGGATGAGAAGATCGATCTGGTGCCGCTGCT
CGGCCATGTCAGAGATGCGCTGGTGCCGCTGGCAAGCGATGTCGGCGTCGACATCAACCTGCATCTGCCCGACGGCAAGG
TCGAGGTGCTCGGAGACCGCGACGAGCTCGTCCAGGTCTTCGAAAACCTGATGGAAAACGCCTGCAAATACGGCCAGGAG
GGCAAGACCGTCGATGTCTGGCTGAAGAACGGCGCCGGCCAGCCGGTCGAGGTCAGCATCGTCGACAAGGGCCCGGGCAT
TCCGGCCGAGCATGTGCCGCGCCTGACCGAGCGCTTCTATCGCGTCAGCATCGAGGACAGCCGGTCGAAAAAAGGCACCG
GCCTCGGCCTTGCCATCGTCAAGCACATCCTCACTCGCCACAGGGCACGGCTGATCGTCAAGTCCGAGGTCGGCAAGGGC
ACCGATTTTACGGTGCGCTTCTGA

Upstream 100 bases:

>100_bases
TGTCATGAATTGCCGCTATCAGGCAGAGTTCAATATTAAGAAAAACGAATCGACGCCGCGAGGGCACTTGCAAGACGAAA
CTCCGTGGAGAAAGAGCCTG

Downstream 100 bases:

>100_bases
CGTGTCCTATGCGAGGTCTGCGAGGGGCGGAGAGGTTGCGGGTCCCGTCTCCCCGAGGGGAGAAGAGGGAGTCGAGAGGT
AGCGGCACGTGCCCTTCGCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MARIRRERPVLLAAILSALAALAAGMNKWVVLGLLLVMIVTALFNEAPVIKDEPAEPVEIAPEVPPSRLPEVSATLSGLD
IPVMVLSDDASVLFQNRAAEKAFGEVALGAHISARLRSPGVLDMVRETIATNAPNQIEHAERLPSERVYIVRSAPIEFSA
EEGARERYFILSFRDISEVRRIDRMRSDFVANASHELRTPLASLRGFIETIQGPAKNDLKAQARFLAIMFDQTTRMSRLV
DDLLSLSRLELKSHIAPDEKIDLVPLLGHVRDALVPLASDVGVDINLHLPDGKVEVLGDRDELVQVFENLMENACKYGQE
GKTVDVWLKNGAGQPVEVSIVDKGPGIPAEHVPRLTERFYRVSIEDSRSKKGTGLGLAIVKHILTRHRARLIVKSEVGKG
TDFTVRF

Sequences:

>Translated_407_residues
MARIRRERPVLLAAILSALAALAAGMNKWVVLGLLLVMIVTALFNEAPVIKDEPAEPVEIAPEVPPSRLPEVSATLSGLD
IPVMVLSDDASVLFQNRAAEKAFGEVALGAHISARLRSPGVLDMVRETIATNAPNQIEHAERLPSERVYIVRSAPIEFSA
EEGARERYFILSFRDISEVRRIDRMRSDFVANASHELRTPLASLRGFIETIQGPAKNDLKAQARFLAIMFDQTTRMSRLV
DDLLSLSRLELKSHIAPDEKIDLVPLLGHVRDALVPLASDVGVDINLHLPDGKVEVLGDRDELVQVFENLMENACKYGQE
GKTVDVWLKNGAGQPVEVSIVDKGPGIPAEHVPRLTERFYRVSIEDSRSKKGTGLGLAIVKHILTRHRARLIVKSEVGKG
TDFTVRF
>Mature_406_residues
ARIRRERPVLLAAILSALAALAAGMNKWVVLGLLLVMIVTALFNEAPVIKDEPAEPVEIAPEVPPSRLPEVSATLSGLDI
PVMVLSDDASVLFQNRAAEKAFGEVALGAHISARLRSPGVLDMVRETIATNAPNQIEHAERLPSERVYIVRSAPIEFSAE
EGARERYFILSFRDISEVRRIDRMRSDFVANASHELRTPLASLRGFIETIQGPAKNDLKAQARFLAIMFDQTTRMSRLVD
DLLSLSRLELKSHIAPDEKIDLVPLLGHVRDALVPLASDVGVDINLHLPDGKVEVLGDRDELVQVFENLMENACKYGQEG
KTVDVWLKNGAGQPVEVSIVDKGPGIPAEHVPRLTERFYRVSIEDSRSKKGTGLGLAIVKHILTRHRARLIVKSEVGKGT
DFTVRF

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=40.343347639485, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=35.3448275862069, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=32.3529411764706, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=31.0810810810811, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994928, Length=256, Percent_Identity=27.34375, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=29.6137339055794, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=25.968992248062, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=30.9012875536481, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789403, Length=199, Percent_Identity=32.6633165829146, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=28.0701754385965, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790861, Length=198, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.6315789473684, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=28, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=235, Percent_Identity=24.2553191489362, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=29.0748898678414, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=25.4464285714286, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=28.9256198347107, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44865; Mature: 44733

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIRRERPVLLAAILSALAALAAGMNKWVVLGLLLVMIVTALFNEAPVIKDEPAEPVEI
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
APEVPPSRLPEVSATLSGLDIPVMVLSDDASVLFQNRAAEKAFGEVALGAHISARLRSPG
CCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCC
VLDMVRETIATNAPNQIEHAERLPSERVYIVRSAPIEFSAEEGARERYFILSFRDISEVR
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCEEEEEEEHHHHHHH
RIDRMRSDFVANASHELRTPLASLRGFIETIQGPAKNDLKAQARFLAIMFDQTTRMSRLV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECCHHHHHHHH
DDLLSLSRLELKSHIAPDEKIDLVPLLGHVRDALVPLASDVGVDINLHLPDGKVEVLGDR
HHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCH
DELVQVFENLMENACKYGQEGKTVDVWLKNGAGQPVEVSIVDKGPGIPAEHVPRLTERFY
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHE
RVSIEDSRSKKGTGLGLAIVKHILTRHRARLIVKSEVGKGTDFTVRF
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEC
>Mature Secondary Structure 
ARIRRERPVLLAAILSALAALAAGMNKWVVLGLLLVMIVTALFNEAPVIKDEPAEPVEI
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
APEVPPSRLPEVSATLSGLDIPVMVLSDDASVLFQNRAAEKAFGEVALGAHISARLRSPG
CCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCC
VLDMVRETIATNAPNQIEHAERLPSERVYIVRSAPIEFSAEEGARERYFILSFRDISEVR
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCEEEEEEEHHHHHHH
RIDRMRSDFVANASHELRTPLASLRGFIETIQGPAKNDLKAQARFLAIMFDQTTRMSRLV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECCHHHHHHHH
DDLLSLSRLELKSHIAPDEKIDLVPLLGHVRDALVPLASDVGVDINLHLPDGKVEVLGDR
HHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCH
DELVQVFENLMENACKYGQEGKTVDVWLKNGAGQPVEVSIVDKGPGIPAEHVPRLTERFY
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHE
RVSIEDSRSKKGTGLGLAIVKHILTRHRARLIVKSEVGKGTDFTVRF
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]