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The map label for this gene is garD [H]

Identifier: 209547765

GI number: 209547765

Start: 150444

End: 151946

Strand: Reverse

Name: garD [H]

Synonym: Rleg2_0154

Alternate gene names: 209547765

Gene position: 151946-150444 (Counterclockwise)

Preceding gene: 209547769

Following gene: 209547764

Centisome position: 3.35

GC content: 64.4

Gene sequence:

>1503_bases
TTGGACAAACTGCCTTGGATCATCCTGTCGGCCGGTGACAATGTCGCGGTCGCAACGGCGGCCATCGCGCCGGGTTCGAC
GGTTGCCGGCATCGAAACCCGTGAAAAAATCGACCCCGGCCACAAGGTGGCGATTTCAGATATTCCGCTCGGCGCCGCCG
TGGTGAAATACGGACAGGCGATCGGCCGCACGACGGCAGATGTCAAGGCCGGCGACCATGTGCACAGCCACAACCTGCAT
TTCGAAAACGACCGGCTGGCGGCAACCGCCAATTCGGCGCCGGAGACAGCGTCGAACGAAGACAAAGCGCGCACCTTCAT
GGGCTATCGCCGCGCCGACGGGCGGGCAGCGACCCGCAACTATATCGGCATCATCGCCAGCGTGAACTGTTCCACCACCG
TCTGCCGGGCAATCGCCGACGAGGCGAACCGGACGATCCTGCCGCATTATGACGGCATCGACGGATTCGTGCCGATCGTG
CACGACCAGGGCTGCGGCATGAGTTCGACCGGCGACGGCATGAACGTGCTGCACCGCACACTTGCCGGCTATACAAGGCA
TGTCAATTTCGGCGGCGTGCTGATGATCGGCCTCGGCTGCGAGGTCAACCAGCTGACGCTTTACGGCCAGAGTGGTGCGG
GCGCCTCGAAGCGGCATTTCAACATCCAGGATGCCGGCGGGTCGCGCCGCGCCGTCGAGCGGGCCATGGGCATGCTGCGC
GAAATCGCCGCCGATGTCGGCAAGGAAAAACGCGTGCCGATGTCGATCGGCGAAATCATCATCGGCCTGCAATGCGGCGG
CTCGGACGGCTTTTCCGGCATCACCGCCAATCCGGCGCTGGGGGTCGCGGCGGATCTGCTGGCAGCCGCCGGCGGCACGG
CGATCCTGTCGGAAACCTCGGAAATCTATGGCGCCGAACATCTGCTGCGCAGCCGCGCCGTCAGCGACGAGGTGGCCAGG
AAACTCGACGAGAAAATCGCCTGGTGGGAGGATTATGTCGCCCTGCACGGCGCCTCGCTCGACAACAACCCCTCTCCCGG
TAACAAACGCGGCGGTCTCACCACCATCCTGGAAAAATCGCTCGGCGCCGTTGCCAAGGGCGGCCGCTCGCCGCTGACGG
CGGTCTATGGTTATGCCGAGCGGGTCACCGCCCCCGGCCTCGTCTTCATGGACACTCCAGGCTACGACCCGGTCTCGGCG
ACCGGCCAGGTGGCGGGTGGAGCGAACATGATCGCCTTTACCACAGGCCGCGGCAGCTGCTTCGGCTGCCGACCGGCGCC
GTCGCTGAAGCTTTCCAGCAATTCGGCGCTCTATGCCTCGATGGAAGAGGACATGGACATCGATTGCGGCACCATCGCTA
CCGGCGATGCGACGATCAGCGGCAAGGGCCGCGAGATCTTCGAGCTCATCGTCGACACGGCCTCCGGCAAGAAGACCAAG
AGCGAACTCTTCGGCTACGGCGACAATGAATTCGTGCCCTGGCATCTCGGCGCAACGCTCTGA

Upstream 100 bases:

>100_bases
TTCGCCGATGCAGCGAGTGTTTCCTGAATTCAACAGTTGGAGCATGATGTCGTCCGAAAACCGCTCAGATTTTCGGTGTC
ATGCTCTGGGGAGAAGAGAC

Downstream 100 bases:

>100_bases
TCTGAAATAGAAAATCCCAAGGCTTGACGAGGAGGCATGATGAAAACGAGACGCATCGGCAAGACCAAGCTTGAGGTGAC
CGAAATCAGCTTCGGCGCCG

Product: altronate dehydratase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MDKLPWIILSAGDNVAVATAAIAPGSTVAGIETREKIDPGHKVAISDIPLGAAVVKYGQAIGRTTADVKAGDHVHSHNLH
FENDRLAATANSAPETASNEDKARTFMGYRRADGRAATRNYIGIIASVNCSTTVCRAIADEANRTILPHYDGIDGFVPIV
HDQGCGMSSTGDGMNVLHRTLAGYTRHVNFGGVLMIGLGCEVNQLTLYGQSGAGASKRHFNIQDAGGSRRAVERAMGMLR
EIAADVGKEKRVPMSIGEIIIGLQCGGSDGFSGITANPALGVAADLLAAAGGTAILSETSEIYGAEHLLRSRAVSDEVAR
KLDEKIAWWEDYVALHGASLDNNPSPGNKRGGLTTILEKSLGAVAKGGRSPLTAVYGYAERVTAPGLVFMDTPGYDPVSA
TGQVAGGANMIAFTTGRGSCFGCRPAPSLKLSSNSALYASMEEDMDIDCGTIATGDATISGKGREIFELIVDTASGKKTK
SELFGYGDNEFVPWHLGATL

Sequences:

>Translated_500_residues
MDKLPWIILSAGDNVAVATAAIAPGSTVAGIETREKIDPGHKVAISDIPLGAAVVKYGQAIGRTTADVKAGDHVHSHNLH
FENDRLAATANSAPETASNEDKARTFMGYRRADGRAATRNYIGIIASVNCSTTVCRAIADEANRTILPHYDGIDGFVPIV
HDQGCGMSSTGDGMNVLHRTLAGYTRHVNFGGVLMIGLGCEVNQLTLYGQSGAGASKRHFNIQDAGGSRRAVERAMGMLR
EIAADVGKEKRVPMSIGEIIIGLQCGGSDGFSGITANPALGVAADLLAAAGGTAILSETSEIYGAEHLLRSRAVSDEVAR
KLDEKIAWWEDYVALHGASLDNNPSPGNKRGGLTTILEKSLGAVAKGGRSPLTAVYGYAERVTAPGLVFMDTPGYDPVSA
TGQVAGGANMIAFTTGRGSCFGCRPAPSLKLSSNSALYASMEEDMDIDCGTIATGDATISGKGREIFELIVDTASGKKTK
SELFGYGDNEFVPWHLGATL
>Mature_500_residues
MDKLPWIILSAGDNVAVATAAIAPGSTVAGIETREKIDPGHKVAISDIPLGAAVVKYGQAIGRTTADVKAGDHVHSHNLH
FENDRLAATANSAPETASNEDKARTFMGYRRADGRAATRNYIGIIASVNCSTTVCRAIADEANRTILPHYDGIDGFVPIV
HDQGCGMSSTGDGMNVLHRTLAGYTRHVNFGGVLMIGLGCEVNQLTLYGQSGAGASKRHFNIQDAGGSRRAVERAMGMLR
EIAADVGKEKRVPMSIGEIIIGLQCGGSDGFSGITANPALGVAADLLAAAGGTAILSETSEIYGAEHLLRSRAVSDEVAR
KLDEKIAWWEDYVALHGASLDNNPSPGNKRGGLTTILEKSLGAVAKGGRSPLTAVYGYAERVTAPGLVFMDTPGYDPVSA
TGQVAGGANMIAFTTGRGSCFGCRPAPSLKLSSNSALYASMEEDMDIDCGTIATGDATISGKGREIFELIVDTASGKKTK
SELFGYGDNEFVPWHLGATL

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=469, Percent_Identity=37.7398720682303, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1789475, Length=488, Percent_Identity=35.2459016393443, Blast_Score=278, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 52187; Mature: 52187

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLPWIILSAGDNVAVATAAIAPGSTVAGIETREKIDPGHKVAISDIPLGAAVVKYGQA
CCCCCEEEEECCCCEEEEEEEECCCCEEECCCHHHHCCCCCEEEEECCCCHHHHHHHHHH
IGRTTADVKAGDHVHSHNLHFENDRLAATANSAPETASNEDKARTFMGYRRADGRAATRN
HCCCCCCCCCCCCEECCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHECCCCCCHHCCC
YIGIIASVNCSTTVCRAIADEANRTILPHYDGIDGFVPIVHDQGCGMSSTGDGMNVLHRT
EEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
LAGYTRHVNFGGVLMIGLGCEVNQLTLYGQSGAGASKRHFNIQDAGGSRRAVERAMGMLR
HHHHHEEECCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
EIAADVGKEKRVPMSIGEIIIGLQCGGSDGFSGITANPALGVAADLLAAAGGTAILSETS
HHHHHCCCCCCCCEEECCEEEEEEECCCCCCCCEECCCCHHHHHHHHHHCCCCCEECCHH
EIYGAEHLLRSRAVSDEVARKLDEKIAWWEDYVALHGASLDNNPSPGNKRGGLTTILEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
LGAVAKGGRSPLTAVYGYAERVTAPGLVFMDTPGYDPVSATGQVAGGANMIAFTTGRGSC
HHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCE
FGCRPAPSLKLSSNSALYASMEEDMDIDCGTIATGDATISGKGREIFELIVDTASGKKTK
EECCCCCCEEECCCCEEEEECCCCCCCCCCEEECCCEEECCCCHHHHHHHHHCCCCCCCH
SELFGYGDNEFVPWHLGATL
HHHCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MDKLPWIILSAGDNVAVATAAIAPGSTVAGIETREKIDPGHKVAISDIPLGAAVVKYGQA
CCCCCEEEEECCCCEEEEEEEECCCCEEECCCHHHHCCCCCEEEEECCCCHHHHHHHHHH
IGRTTADVKAGDHVHSHNLHFENDRLAATANSAPETASNEDKARTFMGYRRADGRAATRN
HCCCCCCCCCCCCEECCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHECCCCCCHHCCC
YIGIIASVNCSTTVCRAIADEANRTILPHYDGIDGFVPIVHDQGCGMSSTGDGMNVLHRT
EEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
LAGYTRHVNFGGVLMIGLGCEVNQLTLYGQSGAGASKRHFNIQDAGGSRRAVERAMGMLR
HHHHHEEECCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
EIAADVGKEKRVPMSIGEIIIGLQCGGSDGFSGITANPALGVAADLLAAAGGTAILSETS
HHHHHCCCCCCCCEEECCEEEEEEECCCCCCCCEECCCCHHHHHHHHHHCCCCCEECCHH
EIYGAEHLLRSRAVSDEVARKLDEKIAWWEDYVALHGASLDNNPSPGNKRGGLTTILEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
LGAVAKGGRSPLTAVYGYAERVTAPGLVFMDTPGYDPVSATGQVAGGANMIAFTTGRGSC
HHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCE
FGCRPAPSLKLSSNSALYASMEEDMDIDCGTIATGDATISGKGREIFELIVDTASGKKTK
EECCCCCCEEECCCCEEEEECCCCCCCCCCEEECCCEEECCCCHHHHHHHHHCCCCCCCH
SELFGYGDNEFVPWHLGATL
HHHCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]