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The map label for this gene is pgi [H]

Identifier: 209547748

GI number: 209547748

Start: 129881

End: 131506

Strand: Reverse

Name: pgi [H]

Synonym: Rleg2_0137

Alternate gene names: 209547748

Gene position: 131506-129881 (Counterclockwise)

Preceding gene: 209547749

Following gene: 209547747

Centisome position: 2.9

GC content: 63.47

Gene sequence:

>1626_bases
ATGAACGCCATCGTCGAACAGCTGAAAAGCACCGCCGCCGCCACCAAGGCGACCGATCTCCGTGCGGCCTTCGCCGCCGA
TTCCGAGCGTTTTTCGCGCTTCTCCGTCTCGCTCGACGACCTCTTGATGGATTTTTCCAAGACGGCGGTGAACGACGACA
TCCTCAAGCTGCTGGTGAAACTCGCCGAAGAAGGCGGCGTCGAGAAGAAGCGCGAGGAGATGTTCTCCGGCAAGGTGATC
AATTTCACCGAGGATCGCGCCGTACTGCACACCGCCCTGCGCAACCGCTCCAACACGCCGGTTCTGGTCGACGGCAAGGA
CGTCATGCCCGATGTCAACGCGGTGCTGGCCGCGATGGGCAAGTTCGCCGACGGCGTCCGCTCCGGCGCGCTGAAGGGCG
CGACCGGCAAAGCGATCACCGATGTCATCAATATCGGCATCGGCGGCTCGGATCTCGGCCCGGTGATGGCGACGCTGGCG
CTTGCCCCGTTCCATGACGGTCCGCGCGCCCATTTCGTCTCCAACATCGACGGCGCCCATATCGCTGATATCCTGAAGCT
GGTGCAGCCGGAGACGACGCTCTTCATCGTCGCCTCGAAGACCTTCACCACGGTGGAGACGATGACCAATGCGCAGACGG
CGCGCAATTTCATCGCCAAGGCGCTCGGCGAAGCGGCCGTGCAGCACCATTTCGCCGCCGTCTCGACGGCGCTCGACAAG
GTCGCCGCCTTCGGCATCGACAGCGCCCGCGTCTTCGGCTTCTGGGACTGGGTCGGCGGCCGTTACTCGATCTGGTCGGC
GATCGGCCTGCCGCTGATGATCGCGATCGGCCCGGAGAATTTCGGCAAGTTCCTCGATGGCGCCCATGCCGTCGACAATC
ACTTCCGTCAGGCGCCGATTACCGAGAACCTGCCGATGCTGCTCGGCCTGATCGGCTTCTACCACCGCAATGTGCTTGAA
TACCCCACCCGCGCCATCCTGCCCTACGACCAGCGCCTGTCGCGCTTCCCCGCCTATCTGCAGCAGCTCGACATGGAATC
GAACGGCAAGGGTGTGACCATCAACGGCACGCCGGTCGAAGGCAATTCCGGCCCCGTCGTCTGGGGCGAGCCCGGCACCA
ACGGCCAGCACGCTTTCTACCAGCTCATCCATCAGGGCACGAGCATCATCCCGGCCGAATTCATGATCGCCGCCAATGCC
TTCGAGCCGGAGCTGCGCCATCAGCACCAGCTGCTGATCTCCAACGTTCTCGCCCAGTCGGAAGCGCTGATGAAGGGCCG
CAGCTTCGCGGAAGCCAAGAAGCAGCTGACCGATAAGGGCATGGACGACAAAAAGGCCGATTTCATCGCTCCGCACCGCG
TCTTCACCGGCAACCGCCCGTCGATCACCTTCGTCTACGACAAGCTGACCCCTTATGCCCTCGGCCGCCTGATCGCGCTT
TACGAACACCGCGTCTTCGTCGAAGGCGTGCTCTTCCGCATCAATTCCTTCGACCAGTGGGGCGTCGAACTCGGCAAGGA
ACTGGCAACGGGCCTGCTGCCTGTCGTCGAGGGCAAGGAGAGTGCGGCCGGGCATGACTCGTCGACGCAGGGCCTGGTTG
CGGCGCTGTCGAAGCTCGCGAAGTAA

Upstream 100 bases:

>100_bases
CGCGGGTGGCTTTTTTCATATTGGAGCGGCGGCTGAACTTGATTTAGGCCGGATAAAGCGAATAGTTTCCGCAACCTTTC
CGCCTCCAAAGGAGCCTCCC

Downstream 100 bases:

>100_bases
GTCCTCGAGGCAGCCGCCTCATCTTAACGCAAGCGGCCGGGCAGACGTCTATGCCCGGCCTTCGCGCCCCATCCTGGGAG
CGACGTCCCGCTGCGGGCCG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MNAIVEQLKSTAAATKATDLRAAFAADSERFSRFSVSLDDLLMDFSKTAVNDDILKLLVKLAEEGGVEKKREEMFSGKVI
NFTEDRAVLHTALRNRSNTPVLVDGKDVMPDVNAVLAAMGKFADGVRSGALKGATGKAITDVINIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADILKLVQPETTLFIVASKTFTTVETMTNAQTARNFIAKALGEAAVQHHFAAVSTALDK
VAAFGIDSARVFGFWDWVGGRYSIWSAIGLPLMIAIGPENFGKFLDGAHAVDNHFRQAPITENLPMLLGLIGFYHRNVLE
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTINGTPVEGNSGPVVWGEPGTNGQHAFYQLIHQGTSIIPAEFMIAANA
FEPELRHQHQLLISNVLAQSEALMKGRSFAEAKKQLTDKGMDDKKADFIAPHRVFTGNRPSITFVYDKLTPYALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVAALSKLAK

Sequences:

>Translated_541_residues
MNAIVEQLKSTAAATKATDLRAAFAADSERFSRFSVSLDDLLMDFSKTAVNDDILKLLVKLAEEGGVEKKREEMFSGKVI
NFTEDRAVLHTALRNRSNTPVLVDGKDVMPDVNAVLAAMGKFADGVRSGALKGATGKAITDVINIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADILKLVQPETTLFIVASKTFTTVETMTNAQTARNFIAKALGEAAVQHHFAAVSTALDK
VAAFGIDSARVFGFWDWVGGRYSIWSAIGLPLMIAIGPENFGKFLDGAHAVDNHFRQAPITENLPMLLGLIGFYHRNVLE
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTINGTPVEGNSGPVVWGEPGTNGQHAFYQLIHQGTSIIPAEFMIAANA
FEPELRHQHQLLISNVLAQSEALMKGRSFAEAKKQLTDKGMDDKKADFIAPHRVFTGNRPSITFVYDKLTPYALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVAALSKLAK
>Mature_541_residues
MNAIVEQLKSTAAATKATDLRAAFAADSERFSRFSVSLDDLLMDFSKTAVNDDILKLLVKLAEEGGVEKKREEMFSGKVI
NFTEDRAVLHTALRNRSNTPVLVDGKDVMPDVNAVLAAMGKFADGVRSGALKGATGKAITDVINIGIGGSDLGPVMATLA
LAPFHDGPRAHFVSNIDGAHIADILKLVQPETTLFIVASKTFTTVETMTNAQTARNFIAKALGEAAVQHHFAAVSTALDK
VAAFGIDSARVFGFWDWVGGRYSIWSAIGLPLMIAIGPENFGKFLDGAHAVDNHFRQAPITENLPMLLGLIGFYHRNVLE
YPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTINGTPVEGNSGPVVWGEPGTNGQHAFYQLIHQGTSIIPAEFMIAANA
FEPELRHQHQLLISNVLAQSEALMKGRSFAEAKKQLTDKGMDDKKADFIAPHRVFTGNRPSITFVYDKLTPYALGRLIAL
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVAALSKLAK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=522, Percent_Identity=55.3639846743295, Blast_Score=603, Evalue=1e-172,
Organism=Homo sapiens, GI296080693, Length=523, Percent_Identity=51.0516252390057, Blast_Score=545, Evalue=1e-155,
Organism=Escherichia coli, GI1790457, Length=512, Percent_Identity=55.859375, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI71996703, Length=537, Percent_Identity=52.8864059590317, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71996708, Length=537, Percent_Identity=52.8864059590317, Blast_Score=580, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319673, Length=526, Percent_Identity=50, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651916, Length=526, Percent_Identity=54.7528517110266, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24651914, Length=526, Percent_Identity=54.7528517110266, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI17737445, Length=526, Percent_Identity=54.7528517110266, Blast_Score=595, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58616; Mature: 58616

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIVEQLKSTAAATKATDLRAAFAADSERFSRFSVSLDDLLMDFSKTAVNDDILKLLVK
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LAEEGGVEKKREEMFSGKVINFTEDRAVLHTALRNRSNTPVLVDGKDVMPDVNAVLAAMG
HHHHCCCHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHH
KFADGVRSGALKGATGKAITDVINIGIGGSDLGPVMATLALAPFHDGPRAHFVSNIDGAH
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHH
IADILKLVQPETTLFIVASKTFTTVETMTNAQTARNFIAKALGEAAVQHHFAAVSTALDK
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAFGIDSARVFGFWDWVGGRYSIWSAIGLPLMIAIGPENFGKFLDGAHAVDNHFRQAPI
HHHHCCCCHHEEEEHHCCCCCHHHHHHHCCCEEEEECCHHHHHHHCCHHHHHHHHHCCCC
TENLPMLLGLIGFYHRNVLEYPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTINGTPVE
CCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GNSGPVVWGEPGTNGQHAFYQLIHQGTSIIPAEFMIAANAFEPELRHQHQLLISNVLAQS
CCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHH
EALMKGRSFAEAKKQLTDKGMDDKKADFIAPHRVFTGNRPSITFVYDKLTPYALGRLIAL
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEEECCCCHHHHHHHHHH
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVAALSKLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHC
K
C
>Mature Secondary Structure
MNAIVEQLKSTAAATKATDLRAAFAADSERFSRFSVSLDDLLMDFSKTAVNDDILKLLVK
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LAEEGGVEKKREEMFSGKVINFTEDRAVLHTALRNRSNTPVLVDGKDVMPDVNAVLAAMG
HHHHCCCHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHH
KFADGVRSGALKGATGKAITDVINIGIGGSDLGPVMATLALAPFHDGPRAHFVSNIDGAH
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHH
IADILKLVQPETTLFIVASKTFTTVETMTNAQTARNFIAKALGEAAVQHHFAAVSTALDK
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAFGIDSARVFGFWDWVGGRYSIWSAIGLPLMIAIGPENFGKFLDGAHAVDNHFRQAPI
HHHHCCCCHHEEEEHHCCCCCHHHHHHHCCCEEEEECCHHHHHHHCCHHHHHHHHHCCCC
TENLPMLLGLIGFYHRNVLEYPTRAILPYDQRLSRFPAYLQQLDMESNGKGVTINGTPVE
CCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GNSGPVVWGEPGTNGQHAFYQLIHQGTSIIPAEFMIAANAFEPELRHQHQLLISNVLAQS
CCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHH
EALMKGRSFAEAKKQLTDKGMDDKKADFIAPHRVFTGNRPSITFVYDKLTPYALGRLIAL
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEEECCCCHHHHHHHHHH
YEHRVFVEGVLFRINSFDQWGVELGKELATGLLPVVEGKESAAGHDSSTQGLVAALSKLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA