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The map label for this gene is tcmR [H]

Identifier: 209547714

GI number: 209547714

Start: 95949

End: 96581

Strand: Direct

Name: tcmR [H]

Synonym: Rleg2_0103

Alternate gene names: 209547714

Gene position: 95949-96581 (Clockwise)

Preceding gene: 209547713

Following gene: 209547715

Centisome position: 2.11

GC content: 64.77

Gene sequence:

>633_bases
ATGGCTGACAGCAAGCGGGCGGCGACGGAAGGCAGGCGGGACCGCAAGCGGCGGCAGACGCGCGAGCGCATCGAGCAGGC
GGCGATGAGCCTCTTTCTCCAGCGCGGTTTCGAGGCCACGACCGTCGAGGACATCACCGAAGCGGCCGATGTCTCCAAAC
GCAGTTTCTTCGATTATTTCCCCTCCAAGGAAGAGGTGGTTTTTGCCTGGCAGGATAGTTTTGCCGATCGGCTGACGGCG
GCTGTCGCCGCAAGGCCGGCAGAAGAGCCCTTGGTGGCTGTGGTCGAGGCGGCGATCACCGCCACCGTCATCGCCTCTAT
CGACGAGCGCGGCCTGGCGCTTGCTGAACTCATCCATCGCACACCGGCGCTGAGGGCCCGTGACCAGCTGAAATATGCGA
GGGTCGAACAGAAGCTCGCCGAGGCGCTGCTTCTGCGCAAGCGAAATGATCCGCAAGAGCGGTCGCGTATGCGCATTCTG
GCGGCGGTCGTCATCGGCGCGTTGCGCGTTGGGGCCGAACTCTGGCAACAGCGCCCGCCGGGTGCGGCGCCGCAGGATTT
TGCCGCGGAAATCTTCGCCGAGCTCTGGAGTATCCTGGCGGAACTCGGTGACGAGGCGAAGGCCAGGCTTTGA

Upstream 100 bases:

>100_bases
TCGCGCGAGCGCTTCAGCTATCGTGAGAGCGAAGCCGAACTCGACGATATCGCCGCTTTCTCCAACGAAACCGGCGGCTG
AGCGATGATGCCGGGCTGAC

Downstream 100 bases:

>100_bases
TGTCGGTCGCTGATACCGCGCACCTGCGGCATTTTCGGTTCCGTCCCTGTCCGCGCCCGCGGCGCCCTCCTATATGTGCA
AGCGTCGTAACGGCCATAGT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MADSKRAATEGRRDRKRRQTRERIEQAAMSLFLQRGFEATTVEDITEAADVSKRSFFDYFPSKEEVVFAWQDSFADRLTA
AVAARPAEEPLVAVVEAAITATVIASIDERGLALAELIHRTPALRARDQLKYARVEQKLAEALLLRKRNDPQERSRMRIL
AAVVIGALRVGAELWQQRPPGAAPQDFAAEIFAELWSILAELGDEAKARL

Sequences:

>Translated_210_residues
MADSKRAATEGRRDRKRRQTRERIEQAAMSLFLQRGFEATTVEDITEAADVSKRSFFDYFPSKEEVVFAWQDSFADRLTA
AVAARPAEEPLVAVVEAAITATVIASIDERGLALAELIHRTPALRARDQLKYARVEQKLAEALLLRKRNDPQERSRMRIL
AAVVIGALRVGAELWQQRPPGAAPQDFAAEIFAELWSILAELGDEAKARL
>Mature_209_residues
ADSKRAATEGRRDRKRRQTRERIEQAAMSLFLQRGFEATTVEDITEAADVSKRSFFDYFPSKEEVVFAWQDSFADRLTAA
VAARPAEEPLVAVVEAAITATVIASIDERGLALAELIHRTPALRARDQLKYARVEQKLAEALLLRKRNDPQERSRMRILA
AVVIGALRVGAELWQQRPPGAAPQDFAAEIFAELWSILAELGDEAKARL

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23502; Mature: 23371

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSKRAATEGRRDRKRRQTRERIEQAAMSLFLQRGFEATTVEDITEAADVSKRSFFDYF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
PSKEEVVFAWQDSFADRLTAAVAARPAEEPLVAVVEAAITATVIASIDERGLALAELIHR
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TPALRARDQLKYARVEQKLAEALLLRKRNDPQERSRMRILAAVVIGALRVGAELWQQRPP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAAPQDFAAEIFAELWSILAELGDEAKARL
CCCCHHHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure 
ADSKRAATEGRRDRKRRQTRERIEQAAMSLFLQRGFEATTVEDITEAADVSKRSFFDYF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
PSKEEVVFAWQDSFADRLTAAVAARPAEEPLVAVVEAAITATVIASIDERGLALAELIHR
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TPALRARDQLKYARVEQKLAEALLLRKRNDPQERSRMRILAAVVIGALRVGAELWQQRPP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAAPQDFAAEIFAELWSILAELGDEAKARL
CCCCHHHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]