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The map label for this gene is trpS [H]

Identifier: 209547638

GI number: 209547638

Start: 23199

End: 24263

Strand: Reverse

Name: trpS [H]

Synonym: Rleg2_0026

Alternate gene names: 209547638

Gene position: 24263-23199 (Counterclockwise)

Preceding gene: 209547639

Following gene: 209547637

Centisome position: 0.53

GC content: 62.44

Gene sequence:

>1065_bases
ATGAGCGAATTCAAGAAACTCGTATTCTCCGGCGTGCAGCCGACCGGCAATCTGCATCTCGGCAATTATCTCGGCGCGAT
CCGCCGCTTCGTGGCGCTGCAGGAGGGCAATGACTGCATCTACTGCGTCGTCGACATGCATGCGCTCACCGCCCAGCTCG
TGCATGAGGACATGCCGAGCCAGACGCGCTCGATCGCCGCCGCCTTCATCGCCGCCGGCATCGATCCTGAAAAACATATC
GTCTTCAACCAGTCGGCCGTGCCGCAGCATGCCGAGCTTGCCTGGATCTTCAATTGCGTCGCCCGCATCGGCTGGATGAA
CCGCATGACGCAGTTCAAGGACAAGGCCGGCAAGGACCGCGAGCAGGCCTCGCTCGGCCTTTACGCCTATCCGAGCCTGA
TGGCCGCCGATATTCTCGTCTATCGCGCCACCCATGTGCCGGTCGGTGAGGATCAGAAGCAGCATCTGGAGCTTGCCCGC
GATATCGCCATGAAGTTCAACCTCGATTATGCCGAGCATATTCGCAAGACCGGCTATGGCATCGACATCACCGTCGGCAA
CGAGCCGGTGCATGCCTATTTCCCGATGGTCGAGCCGCTGATCGGCGGGCCGGCGCCGCGGGTCATGTCGCTGCGCGACG
GCACCAAGAAAATGTCGAAGTCCGACCCGTCCGACCTCTCGCGCATCAACCTGATGGACGACGAGGACGCGATCTCGAAG
AAGATCCGCAAGGCAAAGACCGATCCGGACGGCTTGCCGAGCGAGGTGGACGGGCTGCAGGGCCGGCCGGAAGCCGACAA
TCTGGTGGCGATCTATGCGGCGCTGGCCGACAAATCGAAGGCCGAAGTGCTTGCCGAATTCGGCGGCCAGCAATTCTCCG
TCTTCAAGCCGGCGCTGGTCGATCTCGCCATCCATGTGCTGGCGCCGATCACCGGCGAGATGCGCCGGCTGATGGACGAT
ACCAGCCATATCGACGCCATCCTGCGCAAGGGCGGCGAACGCGCAAGGGCGCGCGCCGAGGTGACGATGAGCCAAGTCCG
CGACGTGATCGGCTTCCTCTACTAA

Upstream 100 bases:

>100_bases
GCCCGTGCATAAGCCGCGGCGTTAGCAACATGGGCGAACAACCCTGCTGCCATGCAGCAAACCAAAGCTGTGGGCCCTCC
ACCAGCCTATTGAGGACGAC

Downstream 100 bases:

>100_bases
GGGTGATCTCTTCTTCTCCCCCGACGGGGAGAAGAGAACCTTCTCCCGGGGGGAGAAGGGGAAAAACTGGGCTTGCAAAT
TTTCCGCTTCGGGTGTCAGA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSEFKKLVFSGVQPTGNLHLGNYLGAIRRFVALQEGNDCIYCVVDMHALTAQLVHEDMPSQTRSIAAAFIAAGIDPEKHI
VFNQSAVPQHAELAWIFNCVARIGWMNRMTQFKDKAGKDREQASLGLYAYPSLMAADILVYRATHVPVGEDQKQHLELAR
DIAMKFNLDYAEHIRKTGYGIDITVGNEPVHAYFPMVEPLIGGPAPRVMSLRDGTKKMSKSDPSDLSRINLMDDEDAISK
KIRKAKTDPDGLPSEVDGLQGRPEADNLVAIYAALADKSKAEVLAEFGGQQFSVFKPALVDLAIHVLAPITGEMRRLMDD
TSHIDAILRKGGERARARAEVTMSQVRDVIGFLY

Sequences:

>Translated_354_residues
MSEFKKLVFSGVQPTGNLHLGNYLGAIRRFVALQEGNDCIYCVVDMHALTAQLVHEDMPSQTRSIAAAFIAAGIDPEKHI
VFNQSAVPQHAELAWIFNCVARIGWMNRMTQFKDKAGKDREQASLGLYAYPSLMAADILVYRATHVPVGEDQKQHLELAR
DIAMKFNLDYAEHIRKTGYGIDITVGNEPVHAYFPMVEPLIGGPAPRVMSLRDGTKKMSKSDPSDLSRINLMDDEDAISK
KIRKAKTDPDGLPSEVDGLQGRPEADNLVAIYAALADKSKAEVLAEFGGQQFSVFKPALVDLAIHVLAPITGEMRRLMDD
TSHIDAILRKGGERARARAEVTMSQVRDVIGFLY
>Mature_353_residues
SEFKKLVFSGVQPTGNLHLGNYLGAIRRFVALQEGNDCIYCVVDMHALTAQLVHEDMPSQTRSIAAAFIAAGIDPEKHIV
FNQSAVPQHAELAWIFNCVARIGWMNRMTQFKDKAGKDREQASLGLYAYPSLMAADILVYRATHVPVGEDQKQHLELARD
IAMKFNLDYAEHIRKTGYGIDITVGNEPVHAYFPMVEPLIGGPAPRVMSLRDGTKKMSKSDPSDLSRINLMDDEDAISKK
IRKAKTDPDGLPSEVDGLQGRPEADNLVAIYAALADKSKAEVLAEFGGQQFSVFKPALVDLAIHVLAPITGEMRRLMDDT
SHIDAILRKGGERARARAEVTMSQVRDVIGFLY

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=354, Percent_Identity=40.1129943502825, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI41352700, Length=172, Percent_Identity=49.4186046511628, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1789786, Length=349, Percent_Identity=40.4011461318052, Blast_Score=269, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71982800, Length=353, Percent_Identity=33.7110481586402, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982793, Length=353, Percent_Identity=33.7110481586402, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320474, Length=364, Percent_Identity=36.5384615384615, Blast_Score=215, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24666151, Length=354, Percent_Identity=36.7231638418079, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 39106; Mature: 38975

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFKKLVFSGVQPTGNLHLGNYLGAIRRFVALQEGNDCIYCVVDMHALTAQLVHEDMPS
CCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHCCCH
QTRSIAAAFIAAGIDPEKHIVFNQSAVPQHAELAWIFNCVARIGWMNRMTQFKDKAGKDR
HHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EQASLGLYAYPSLMAADILVYRATHVPVGEDQKQHLELARDIAMKFNLDYAEHIRKTGYG
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
IDITVGNEPVHAYFPMVEPLIGGPAPRVMSLRDGTKKMSKSDPSDLSRINLMDDEDAISK
EEEEECCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCCHHHHCCCCCCHHHHHH
KIRKAKTDPDGLPSEVDGLQGRPEADNLVAIYAALADKSKAEVLAEFGGQQFSVFKPALV
HHHHCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEHHHHHHHH
DLAIHVLAPITGEMRRLMDDTSHIDAILRKGGERARARAEVTMSQVRDVIGFLY
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEFKKLVFSGVQPTGNLHLGNYLGAIRRFVALQEGNDCIYCVVDMHALTAQLVHEDMPS
CHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHCCCH
QTRSIAAAFIAAGIDPEKHIVFNQSAVPQHAELAWIFNCVARIGWMNRMTQFKDKAGKDR
HHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EQASLGLYAYPSLMAADILVYRATHVPVGEDQKQHLELARDIAMKFNLDYAEHIRKTGYG
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
IDITVGNEPVHAYFPMVEPLIGGPAPRVMSLRDGTKKMSKSDPSDLSRINLMDDEDAISK
EEEEECCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCCHHHHCCCCCCHHHHHH
KIRKAKTDPDGLPSEVDGLQGRPEADNLVAIYAALADKSKAEVLAEFGGQQFSVFKPALV
HHHHCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEHHHHHHHH
DLAIHVLAPITGEMRRLMDDTSHIDAILRKGGERARARAEVTMSQVRDVIGFLY
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]