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The map label for this gene is astC [H]

Identifier: 209400956

GI number: 209400956

Start: 2336568

End: 2337788

Strand: Reverse

Name: astC [H]

Synonym: ECH74115_2466

Alternate gene names: 209400956

Gene position: 2337788-2336568 (Counterclockwise)

Preceding gene: 209397500

Following gene: 209398676

Centisome position: 41.96

GC content: 54.05

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCTCCGGCACCGTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAGGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGTCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTTTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCGCTAAAACTGGCGCGTAAATTCGCTCACGACCGCTACGGCAGCCATAAGAGCGGTATCGTGGCGT
TTAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTTAGTGCGGGTGGGCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCACCAGATATCCGTCATGCTGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACTCTACCTGTGCGGT
GATTGTCGAACCCATCCAGGGTGAAGGCGGTGTGGTGCCAGCCAGCAACGCATTTTTACAAGGTCTGCGTGAATTGTGTG
ATCGCCACAATGCGCTGTTGATTTTTGATGAAGTACAAACCGGCGTCGGGCGTACCGGGGAACTGTATGCCTATATGCAC
TACGGCGTGACGCCTGATCTGTTAACTACCGCCAAAGCTCTGGGCGGCGGTTTCCCGGTCGGTGCGTTGTTAGCAACCGA
AGAGTGCGCCAGCGTGATGACCGTTGGCACTCATGGCACCACCTATGGCGGCAATCCGCTGGCCTCGGCGGTGGCAGGCA
AAGTGCTGGAGCTCATCAATACGCCAGAGATGCTTAACGGGGTTAAGCAACGTCACGACTGGTTTGTTGAGCGTCTTAAT
ATTATTAATCACCGCTATGGTTTGTTCAATGAAGTTCGCGGCTTAGGTTTGCTGATTGGCTGTGTACTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGCGAAAGCAGGCGTGATGGTACTGATTGCGGGTGGCAACGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGTTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTCATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGAAAACATTACTTATTATTAACATATAAATAACGAGC
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGCTCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
ESVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
IINHRYGLFNEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAVACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
ESVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
IINHRYGLFNEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAVACEHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
SVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNI
INHRYGLFNEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAVACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=35.0923482849604, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.8361774744027, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=27.765237020316, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.7251184834123, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=27.0142180094787, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.906976744186, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=413, Percent_Identity=28.0871670702179, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI188536080, Length=422, Percent_Identity=24.6445497630332, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679950, Length=422, Percent_Identity=24.6445497630332, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679946, Length=422, Percent_Identity=24.6445497630332, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=98.2758620689655, Blast_Score=824, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=59.9496221662469, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=33.9195979899498, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI145693181, Length=372, Percent_Identity=35.752688172043, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=34.6835443037975, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=31.8452380952381, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.0945945945946, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=379, Percent_Identity=35.8839050131926, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.8850574712644, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=275, Percent_Identity=34.5454545454545, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.8683602771363, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=26.9480519480519, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=34.5454545454545, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=40.0497512437811, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323470, Length=396, Percent_Identity=34.0909090909091, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.6153846153846, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=26.5027322404372, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.3562005277045, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.2134831460674, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.2035398230088, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=29.3628808864266, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=24.3559718969555, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=24.3559718969555, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=24.3559718969555, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43681; Mature: 43550

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNESVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNIINHRYGLFNEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAVACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNESVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNIINHRYGLFNEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAVACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA