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The map label for this gene is srlD [H]

Identifier: 209400828

GI number: 209400828

Start: 3655900

End: 3656679

Strand: Direct

Name: srlD [H]

Synonym: ECH74115_3955

Alternate gene names: 209400828

Gene position: 3655900-3656679 (Clockwise)

Preceding gene: 209400572

Following gene: 209399048

Centisome position: 65.61

GC content: 52.31

Gene sequence:

>780_bases
ATGAATCAGGTTGCCGTTGTCATCGGTGGTGGGCAAACCTTAGGCGCGTTCCTGTGCCACGGTCTGGCTGCCGAGGGGTA
TCGCGTCGCGGTTGTCGATATTCAGAGCGACAAAGCCGCAAATGTGGCACAAGAAATTAACGCCGAATATGGTGAAGGAA
CAGCGTATGGTTTTGGTGCTGACGCCACTAGCGAGCAAAGCGTTCTGGCGCTCTCTCGTGGGGTAGATGAAATCTTTGTT
CGTGTGGATTTACTGGTCTACAGCGCCGGAATTGCAAAAGCAGCCTTTATCAGCGACTTCCAGCTCGGCGATTTTGACCG
TTCGCTACAGGTGAATCTGGTGGGTTATTTCCTGTGTGCGCGTGAATTTTCGCGTTTGATGATCCGCGATGGGATTCAGG
GACGCATTATTCAGATCAACTCGAAATCCGGCAAAGTGGGCAGCAAACACAATTCTGGTTATAGCGCCGCGAAATTTGGT
GGCGTAGGGCTGACTCAATCACTGGCGCTGGATCTGGCGGAGTACGGCATTACGGTGCATTCACTGATGCTCGGTAACCT
GCTGAAATCGCCGATGTTCCAGTCGCTGTTGCCACAATATGCCACCAAGCTGGGTATCAAACCGGATCAAGTCGAGCAGT
ATTACATCGACAAAGTACCGCTCAAACGCGGCTGCGATTATCAGGATGTGCTGAATATGCTGCTGTTCTACGCCAGTCCT
AAGGCGTCGTACTGTACCGGACAGTCGATCAATGTCACCGGCGGTCAGGTGATGTTCTGA

Upstream 100 bases:

>100_bases
CGAAGCGGAATTTCCGGGCACTGTCCATGTGGCAGGCCCTGTACCCGACGATATCGCGCCGGGATCGGTTTTGAAGTTTG
AATCTGTTAAGGAGTAAAAA

Downstream 100 bases:

>100_bases
TCAACAGCGGAGATCCGTTAAGGATCTCCGTGAGACTAATAGAATGCCTGATGCGCTACGCTCATCAGGCATACAGGACT
TCCGCCACTACATTAAGGAA

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGEGTAYGFGADATSEQSVLALSRGVDEIFV
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Sequences:

>Translated_259_residues
MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGEGTAYGFGADATSEQSVLALSRGVDEIFV
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF
>Mature_259_residues
MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGEGTAYGFGADATSEQSVLALSRGVDEIFV
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=33.2075471698113, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=26.953125, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4758504, Length=233, Percent_Identity=31.7596566523605, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI83715985, Length=233, Percent_Identity=30.4721030042918, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=98.8416988416988, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.515625, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=29.0196078431373, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=30.3501945525292, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=27.7992277992278, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788459, Length=264, Percent_Identity=28.030303030303, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=27.6264591439689, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=22.1343873517787, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=25.968992248062, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.740157480315, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.1338582677165, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=30.1775147928994, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=228, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=25.5555555555556, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=31.2796208530806, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=28.2352941176471, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737361, Length=233, Percent_Identity=30.4721030042918, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=27.3076923076923, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27840; Mature: 27840

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGEGTAYGFGA
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCC
DATSEQSVLALSRGVDEIFVRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure
MNQVAVVIGGGQTLGAFLCHGLAAEGYRVAVVDIQSDKAANVAQEINAEYGEGTAYGFGA
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCC
DATSEQSVLALSRGVDEIFVRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]