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The map label for this gene is ldcC1 [H]

Identifier: 209400786

GI number: 209400786

Start: 213003

End: 215144

Strand: Direct

Name: ldcC1 [H]

Synonym: ECH74115_0196

Alternate gene names: 209400786

Gene position: 213003-215144 (Clockwise)

Preceding gene: 209398883

Following gene: 209396730

Centisome position: 3.82

GC content: 50.98

Gene sequence:

>2142_bases
ATGAACATCATTGCCATTATGGGACCGCATGGCGTCTTTTATAAAGATGAGCCCATCAAAGAACTGGAGTCGGCGCTGGT
GGCGCAAGGCTTTCAGATTATCTGGCCACAAAACAGCGTTGATTTGCTGAAATTTATCGAACATAACCCTCGAATTTGCG
GCGTGATTTTTGACTGGGATGAATACAGTCTCGATTTATGTAGCGATATCAATCAGCTTAATGAATATCTCCCGCTTTAT
GCCTTCATCAACACCCACTCGACGATGGATGTCAGCGTGCAGGATATGCGGATGGCGCTCTGTTTTTTTGAATATGCGCT
GGGGCAGGCGGAAGATATCGCCATTCGTATGCGTCAGTACACCGACGAATATCTTGATAACATTACCCCACCGTTCACGA
AAGCCTTGTTTACCTACGTCAAAGAGCGGAAGTACACCTTTTGTACGCCGGGTCATATGGGCGGCACCGCATATCAAAAA
AGCCCGGTTGGCTGTCTGTTTTATGACTTTTTCGGCGGGAATACCCTTAAGGCTGATGTCTCTATTTCGGTCACCGAGCT
TGGTTCGTTGCTCGACCACACCGGGCCACACCTGGAAGCGGAAGAGTACATCGCGCGGACTTTCGGCGCGGAACAGAGTT
ATATCGTTACCAACGGAACATCGACGTCGAACAAAATTGTGGGTATGTACGCCGCGCCATCCGGCAGTACGCTGTTGATT
GACCGCAATTGTCATAAATCGCTGGCGCATCTGTTGATGATGAACGATGTAGTGCCAGTCTGGCTGAAACCGACGCGTAA
TGCGTTGGGGATTCTGGGTGGGATCCCGCGCCGTGAATTTACTCGCGACAGCATCGAAGAGAAAGTCGCTGCCACCACGC
AGGCACAATGGCCGGTTCATGCGGTGATTACCAACTCAACCTATGATGGCTTGCTCTACAACACCGACTGGATCAAACAG
ACGCTGGATGTCCCGTCGATCCACTTCGATTCCGCCTGGGTGCCGTACACCCATTTTCATCCGATCTACCAGGGGAAAAG
TGGTATGAGCGGCGAGCGTGTTGCGGGAAAAGTGATCTTCGAAACGCAATCGACCCACAAAATGCTGGCGGCGTTATCGC
AGGCTTCGCTGATCCACATTAAAGGTGAGTATGACGAAGAGGCGTTTAACGAAGCCTTTATGATGCATACCACCACCTCG
CCCAGTTATCCCATTGTTGCTTCGGTTGAGACGGCAGCAGCGATGCTGCGTGGTAATCCGGGCAAACGGCTGATTAACCG
TTCAGTAGAACGAGCTCTGCATTTTCGCAAAGAGGTCCAGCGGCTGCGGGAAGAGTCTGACGGTTGGTTTTTCGATATCT
GGCAACCGCCGCAGGTGGATGAAGCCGAATGCTGGCCCGTTGCGCCTGGCGAACAATGGCACGGCTTTAACGATGCGGAT
GCCGATCATATGTTCCTCGATCCGGTTAAAGTCACTATTCTGACGCCGGGGATGGACGAGCAGGGCAATATGAGCGAGGA
GGGGATCCCGGCGGCGCTGGTGGCGAAGTTCCTCGATGAGCGTGGGATCGTGGTAGAGAAAACCGGCCCATATAACCTGC
TGTTTCTCTTTAGTATTGGCATCGATAAAACCAAAGCAATGGGATTATTGCGTGGGTTGACGGAATTTAAACGCTCTTAC
GATCTCAATCTGCGAATCAAAAATATGCTTCCGGATCTGTACGCAGAAGATCCCGATTTCTACCGCAATATGCGTATTCA
GGATCTGGCGCAAGGGATCCATAAGCTGATTCGTAAACACGATCTTCCCGGTTTGATGTTGCGGGCATTCGATACTTTGC
CGGAGATGATCATGACGCCACATCAGGCATGGCAGAGACAGATTAAAGGTGAAGTAGAAACCATTGCGCTGGAACAACTG
GTCGGTAGAGTATCGGCAAATATGATCCTGCCTTATCCACCGGGCGTACCGCTGTTGATGCCTGGAGAAATGCTGACCAA
AGAGAGCCGCACAGTACTCGATTTTCTACTGATGCTTTGTTCCGTAGGGCAACATTACCCCGGTTTTGAAACGGATATTC
ACGGTGCGAAACAGGACGAAGACGGCGTTTACCGCGTACGAGTCCTAAAAATGGCGGGATAA

Upstream 100 bases:

>100_bases
AATTCGCAAAAGTTCTGAAAAAGGGTCACTTCGGTGGCCCTTTTTTATCGCCACGGTTTGAGCAGGCTATGATTAAGGAA
GGATTTTCCAGGAGGAACAC

Downstream 100 bases:

>100_bases
CTTGCCAGAGCGGCTTCCGGGCGAGTAACGTGCTGTTAACAAATAAAGGAGACGTTATGCTGGGTTTAAAACAGGTTCAC
CATATTGCGATTATTGCGAC

Product: lysine decarboxylase, constitutive

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALCFFEYALGQAEDIAIRMRQYTDEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGTSTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVIFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECWPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLPGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG

Sequences:

>Translated_713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALCFFEYALGQAEDIAIRMRQYTDEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGTSTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVIFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECWPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLPGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
>Mature_713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALCFFEYALGQAEDIAIRMRQYTDEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGTSTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVIFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECWPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLPGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=713, Percent_Identity=99.859747545582, Blast_Score=1487, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=710, Percent_Identity=69.4366197183099, Blast_Score=1090, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=34.9659863945578, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI87082193, Length=621, Percent_Identity=34.1384863123994, Blast_Score=328, Evalue=1e-90,
Organism=Escherichia coli, GI1786909, Length=692, Percent_Identity=31.2138728323699, Blast_Score=302, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80508; Mature: 80508

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSDINQLNEYLPLYAFINTHSTMDVSVQDMRMALCFFEYALGQAEDIAIRMRQY
CCCHHHHHHHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TDEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGTSTSNKIVGMYAAPSGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVH
ECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEE
AVITNSTYDGLLYNTDWIKQTLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVIF
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
ETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTSPSYPIVASVETAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECWPVAPGEQWHGFNDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMGLLRGLTEFKRSYDLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKH
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQLVGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEC
PGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSDINQLNEYLPLYAFINTHSTMDVSVQDMRMALCFFEYALGQAEDIAIRMRQY
CCCHHHHHHHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TDEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGTSTSNKIVGMYAAPSGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVH
ECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEE
AVITNSTYDGLLYNTDWIKQTLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVIF
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
ETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTSPSYPIVASVETAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECWPVAPGEQWHGFNDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMGLLRGLTEFKRSYDLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKH
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQLVGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEC
PGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]