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The map label for this gene is uhpC [H]

Identifier: 209400657

GI number: 209400657

Start: 445971

End: 447275

Strand: Reverse

Name: uhpC [H]

Synonym: ECH74115_0436

Alternate gene names: 209400657

Gene position: 447275-445971 (Counterclockwise)

Preceding gene: 209399895

Following gene: 209399886

Centisome position: 8.03

GC content: 55.48

Gene sequence:

>1305_bases
ATGCACGCGCGTTCAGCGAGAGAAATTAATCAATGCTACCGGACATTACGTCCGCGATTGCTGATGTGCATGATTATTGG
CTACGCCGCATTTTATCTGACGCGAAAAAGCGTGAATTACGTCCTTCCGGCGCTACAAACCGACCTCGGACTGGATAAAG
GCGACATTGGCCTGCTGGGTTCGCTGTTTTATCTCAGCTACGGATTGTCGAAATTTACCGCCGGACTGTGGCATGACAGC
CACGGACAACGCGGTTTTATGGGCGTCGGCTTGTTCGCCACCGGGTTATTGAACGTGGTGTTTGCCTTTGGCGAATCACT
TACGCTTCTGCTTGTGGTCTGGACACTGAACGGTTTTTTTCAGGGCTGGGGATGGCCACCGTGTGCCCGCTTGCTGACCC
ACTGGTACTCACGCAATGAGCGCGGTTTCTGGTGGGGCTGCTGGAATATGTCGATCAACATTGGCGGAGCGATTATTCCG
CTGATTAGCGCCTTTGCCGCCCACTGGTGGGGCTGGCAGGCCGCGATGCTGACACCGGGGATAATCAGCATGGCATTAGG
GATCTGGTTAACGCTACAACTCAAAGGCACGCCCCAGGAAGAGGGATTACCGACAGTTGGTCACTGGCGTCACGATCCGC
TGGAGTTACGTCAGGAACAACAAAGTCCGCCGATGGGGCTGTGGCAAATGTTGCGCACCACCATGCTGCAAAATCCGCTG
ATCTGGCTACTGGGCGTCTCATATGTACTGGTTTATGTGATCCGGATTGCGCTTAACGACTGGGGCAATATCTGGCTGAC
GGAAAGCCACGGTGTCAACCTGCTCAGCGCCAACGCCACGGTAATGCTGTTTGAAGTGGGCGGCTTACTCGGCGCGTTAT
TTGCCGGATGGGGATCGGATTTGCTGTTTAGCGGGCAACGAGCGCCAATGATTTTGCTGTTCACGTTGGGGTTGATGGTG
TCAGTCGCCGCACTGTGGCTGGCACCGGTTCATCACTACGCTCTGCTGGCAGTGTGCTTTTTTACCGTGGGCTTTTTCGT
CTTTGGCCCACAAATGCTGATTGGACTTGCGGCGGTGGAGTGTGGGCACAAAGCTGCGGCGGGTTCAATCACCGGATTTC
TCGGCCTGTTCGCTTACCTTGGCGCGGCGCTGGCAGGCTGGCCGCTGTCGCTGGTCATCGAACGCTACGGCTGGCCGGGA
ATGTTCAGTTTACTCTCGGTCGCCGCAGTACTTATGGGTTTACTGCTGATGCCGTTACTGATGGCGGGCATCACCACCAC
TCACGCTCGAAGGATAAAACAATGA

Upstream 100 bases:

>100_bases
ACAAATCGCCGGATAACCAGGAAAAAGTCTTAGGTATCCCGGATTTTCTCTCATCCCCTTTCACTTTCATTTTCATATAG
TCAGCAACATGGAGACAACC

Downstream 100 bases:

>100_bases
AAATGACCTTTACCTCTACTCTGATTGCTTCTGCCGTTGCGCTGGCGACTTTAACGGGTGCCGCGCAGGCAAAAGGCCGG
CTGGTGGTCTATTGCAGCGC

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLGSLFYLSYGLSKFTAGLWHDS
HGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFFQGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIP
LISAFAAHWWGWQAAMLTPGIISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSDLLFSGQRAPMILLFTLGLMV
SVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVECGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPG
MFSLLSVAAVLMGLLLMPLLMAGITTTHARRIKQ

Sequences:

>Translated_434_residues
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLGSLFYLSYGLSKFTAGLWHDS
HGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFFQGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIP
LISAFAAHWWGWQAAMLTPGIISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSDLLFSGQRAPMILLFTLGLMV
SVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVECGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPG
MFSLLSVAAVLMGLLLMPLLMAGITTTHARRIKQ
>Mature_434_residues
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLGSLFYLSYGLSKFTAGLWHDS
HGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFFQGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIP
LISAFAAHWWGWQAAMLTPGIISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSDLLFSGQRAPMILLFTLGLMV
SVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVECGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPG
MFSLLSVAAVLMGLLLMPLLMAGITTTHARRIKQ

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=405, Percent_Identity=28.1481481481481, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4503847, Length=405, Percent_Identity=28.1481481481481, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI256219483, Length=405, Percent_Identity=28.1481481481481, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI256219543, Length=424, Percent_Identity=27.3584905660377, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI256219564, Length=326, Percent_Identity=27.3006134969325, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI46361976, Length=411, Percent_Identity=23.1143552311436, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI223717983, Length=481, Percent_Identity=22.2453222453222, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38093649, Length=481, Percent_Identity=22.2453222453222, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI49619231, Length=400, Percent_Identity=24.5, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082310, Length=415, Percent_Identity=53.2530120481928, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1788573, Length=435, Percent_Identity=31.264367816092, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI2367259, Length=432, Percent_Identity=29.1666666666667, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI2367379, Length=384, Percent_Identity=24.4791666666667, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561094, Length=400, Percent_Identity=23.5, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17542316, Length=465, Percent_Identity=23.6559139784946, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI133901854, Length=435, Percent_Identity=24.1379310344828, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI133901856, Length=435, Percent_Identity=24.1379310344828, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI133930953, Length=408, Percent_Identity=23.2843137254902, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539138, Length=322, Percent_Identity=22.0496894409938, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656866, Length=485, Percent_Identity=25.7731958762887, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45550478, Length=485, Percent_Identity=25.7731958762887, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24656861, Length=485, Percent_Identity=25.7731958762887, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47921; Mature: 47921

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SLFYLSYGLSKFTAGLWHDSHGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIPLISAFAAHWWGWQAAMLTPG
CCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHCHH
IISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
HHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCH
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSD
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCH
LLFSGQRAPMILLFTLGLMVSVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPGMFSLLSVAAVLMGLLLMPLL
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MAGITTTHARRIKQ
HHHHHHHHHHHCCC
>Mature Secondary Structure
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SLFYLSYGLSKFTAGLWHDSHGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFF
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIPLISAFAAHWWGWQAAMLTPG
CCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHCHH
IISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
HHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCH
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSD
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCEEEEEHHHHHHHHHHHCCCCH
LLFSGQRAPMILLFTLGLMVSVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPGMFSLLSVAAVLMGLLLMPLL
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MAGITTTHARRIKQ
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]