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The map label for this gene is dacC [H]

Identifier: 209400303

GI number: 209400303

Start: 1009368

End: 1010579

Strand: Direct

Name: dacC [H]

Synonym: ECH74115_0992

Alternate gene names: 209400303

Gene position: 1009368-1010579 (Clockwise)

Preceding gene: 209399419

Following gene: 209400914

Centisome position: 18.11

GC content: 51.9

Gene sequence:

>1212_bases
GTGGCATTTATGACGCAATACTCCTCTCTCCTTCGTGGTCTTGCAGCGGGTTCTGCATTTTTATTCCTTTTTGCCCCAAC
GGCATTCGCGGCCGAACAAACCGTTGAAGCGCCGAGCGTGGATGCGCGTGCATGGATTTTAATGGATTACGCCAGCGGTA
AAGTGCTGGCAGAAGGCAATGCGGATGAGAAACTGGATCCCGCGAGCCTGACTAAAATCATGACCAGCTATGTGGTTGGG
CAGGCGCTTAAGGCCGATAAGATTAAACTCACCGATATGGTGACGGTCGGTAAAGATGCCTGGGCGACGGGAAATCCGGC
ACTGCGTGGTTCATCGGTAATGTTCCTCAAACCGGGCGATCAGGTTTCGGTGGCAGACTTGAACAAAGGTGTGATTATCC
AGTCCGGTAATGACGCCTGTATTGCGCTGGCCGATTACGTTGCCGGGAGCCAGGAGTCATTTATTGGTTTGATGAATGGT
TATGCCAAAAAACTGGGGCTGACCAACACTACCTTCCAGACGGTGCACGGTCTGGATGCGCCGGGGCAGTTCAGTACCGC
GCGCGATATGGCATTGCTGGGTAAAGCATTGATCCACGATGTGCCGGAAGAGTACGCCATTCATAAAGAGAAAGAGTTCA
CCTTCAACAAAATTCGTCAGCCTAACCGTAACCGTCTGCTGTGGAGCAGCAATCTGAATGTTGATGGCATGAAGACAGGA
ACCACGGCAGGCGCGGGATATAATCTGGTTGCTTCGGCTACCCAGGGCGATATGCGTTTAATCTCCGTAGTGCTGGGGGC
GAAAACCGACCGTATCCGTTTTAATGAGTCTGAGAAATTATTGACCTGGGGTTTCCGCTTCTTTGAAACCGTGACGCCAA
TTAAACCTGATGCCACCTTTGTGACTCAGCGCGTCTGGTTTGGTGATAAGAGCGAAGTGAATCTCGGGGCAGGCGAAGCG
GGCTCAGTGACCATACCGCGTGGGCAGCTGAAAAACCTGAAGGCGAGCTACACGTTAACGGAACCGCAGCTTACCGCACC
GCTGAAAAAAGGTCAGGTTGTCGGGACCATTGATTTCCAGCTTAACGGTAAATCCATTGAGCAGCGTCCGCTGATCGTGA
TGGAAAATGTGGAAGAGGGCGGATTCTTTGGTCGGATGTGGGATTTCGTGATGATGAAATTCCATCAGTGGTTCGGCAGC
TGGTTCTCTTAA

Upstream 100 bases:

>100_bases
AACTTTACCAACTTACGGTTTCTTTAAGTTTGTGTGTGCGTTATTAATCACCGAACTTATCATACGGCGATATAACGTAT
TTTTTTGAATGGATACTCGG

Downstream 100 bases:

>100_bases
TCTTCTGATAACCGGATGGCGCGAAACGTCATCCGGTTATACGTCATTAATACATCAACTTAATACGCTGCGTCTGCGCG
TACTTCACATACTCATCTTC

Product: D-alanyl-D-alanine carboxypeptidase fraction C

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAFMTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVG
QALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNG
YAKKLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTG
TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEA
GSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGS
WFS

Sequences:

>Translated_403_residues
MAFMTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVG
QALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNG
YAKKLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTG
TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEA
GSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGS
WFS
>Mature_402_residues
AFMTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQ
ALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGY
AKKLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGT
TAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAG
SVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGSW
FS

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=400, Percent_Identity=99.75, Blast_Score=820, Evalue=0.0,
Organism=Escherichia coli, GI1786851, Length=397, Percent_Identity=60.2015113350126, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=47.7922077922078, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI87082054, Length=251, Percent_Identity=27.0916334661355, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43991; Mature: 43860

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFMTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGN
CCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCEEEECCC
ADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCC
QVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDA
EEEEEECCCCEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTG
CCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCC
TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATF
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCE
VTQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ
EEEEEECCCCCCEEECCCCCCCEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEE
LNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGSWFS
ECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFMTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGN
CHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCEEEECCC
ADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCC
QVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDA
EEEEEECCCCEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTG
CCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCC
TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATF
CCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCE
VTQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ
EEEEEECCCCCCEEECCCCCCCEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEE
LNGKSIEQRPLIVMENVEEGGFFGRMWDFVMMKFHQWFGSWFS
ECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]