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The map label for this gene is adhB [H]

Identifier: 209400248

GI number: 209400248

Start: 4602482

End: 4603633

Strand: Reverse

Name: adhB [H]

Synonym: ECH74115_4960

Alternate gene names: 209400248

Gene position: 4603633-4602482 (Counterclockwise)

Preceding gene: 209399470

Following gene: 209395834

Centisome position: 82.62

GC content: 50.69

Gene sequence:

>1152_bases
ATGGCATCTTCAACTTTCTTTATTCCTTCTGTGAATGTCATCGGCGCTGATTCATTGACTGATGCAATGAATATGATGGC
AGATTATGGATTTACCCGTACCTTAATTGTCACTGACAGTATGTTAACGAAATTAGGTATGGCGGGCGATGTGCAAAAAG
CACTGGAAGAACGCAATATTTTTAGCGTTATTTATGATGGCACCCAACCTAACCCCACCACGGAAAACGTCGCCGCAGGT
TTGAAATTACTTAAAGAGAATAATTGCGATAGCGTGATCTCCTTAGGCGGTGGTTCTCCACACGACTGCGCAAAAGGTAT
TGCGCTGGTGGCAGCCAATGGCGGCGATATTCGCGATTACGAAGGCGTTGACCGCTCTGCAAAACCGCAGCTGCCGATGA
TCGCCATCAATACCACGGCGGGTACGGCCTCTGAAATGACCCGTTTCTGCATCATCACTGACGAAGCGCGTCATATCAAA
ATGGCGATTGTTGATAAACATGTCACTCCGCTGCTTTCTGTCAATGACTCCTCTCTGATGATTGGTATGCCGAAGTCACT
GACCGCCGCAACGGGTATGGATGCCTTAACGCACGCTATCGAAGCGTATGTTTCTATTGCCGCCACGCCGATCACTGACG
CTTGTGCACTGAAAGCCGTGACCATGATTGCCGAAAACCTGCCGTTAGCCGTTGAAGATGGCAGTAATGCGAAAGCGCGT
GAAGCAATGGCTTATGCCCAGTTCCTCGCCGGTATGGCGTTCAATAATGCTTCTCTGGGTTATGTTCATGCGATGGCGCA
CCAGCTGGGCGGTTTCTACAACCTGCCACACGGTGTATGTAACGCCGTTCTGCTGCCGCATGTTCAGGTATTCAACAGCA
AAGTCGCCGCTGCACGTCTGCGTGACTGTGCCGCTGCAATGGGCGTGAACGTGACAGGTAAAAACGACGCGGAAGGTGCT
GAAGCCTGCATTAACGCCATCCGTGAACTGGCGAAGAAAGTGGATATCCCGGCAGGCCTACGCGACCTGAACGTGAAAGA
AGAAGATTTCGCGGTTCTGGCGGCTAATGCCCTGAAAGATGCCTGTGGCTTTACTAACCCGATCCAGGCAACTCACGAAG
AAATTGTGGCGATTTATCGCGCAGCGATGTAA

Upstream 100 bases:

>100_bases
TTTATTAGATTAATTTTGATAATTAATAATAATGATCATGTTTTCGAATGAAAATCCTCAGTAAGCTGCCCACCCTTTTT
TACACTTTCAGGAGTGTGTT

Downstream 100 bases:

>100_bases
TCATCATTTCCACAACGGCTGGCAAATTGTCAGCCATTTTTTCAACTATCTCAAAACTTGCTTTTTTTGAGATAGTTTCT
CTTTCCTGCTATACACTATC

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MASSTFFIPSVNVIGADSLTDAMNMMADYGFTRTLIVTDSMLTKLGMAGDVQKALEERNIFSVIYDGTQPNPTTENVAAG
LKLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIK
MAIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGA
EACINAIRELAKKVDIPAGLRDLNVKEEDFAVLAANALKDACGFTNPIQATHEEIVAIYRAAM

Sequences:

>Translated_383_residues
MASSTFFIPSVNVIGADSLTDAMNMMADYGFTRTLIVTDSMLTKLGMAGDVQKALEERNIFSVIYDGTQPNPTTENVAAG
LKLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIK
MAIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGA
EACINAIRELAKKVDIPAGLRDLNVKEEDFAVLAANALKDACGFTNPIQATHEEIVAIYRAAM
>Mature_382_residues
ASSTFFIPSVNVIGADSLTDAMNMMADYGFTRTLIVTDSMLTKLGMAGDVQKALEERNIFSVIYDGTQPNPTTENVAAGL
KLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKM
AIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKARE
AMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGAE
ACINAIRELAKKVDIPAGLRDLNVKEEDFAVLAANALKDACGFTNPIQATHEEIVAIYRAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=398, Percent_Identity=24.6231155778894, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=99.2167101827676, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=356, Percent_Identity=43.8202247191011, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=37.3015873015873, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1787493, Length=383, Percent_Identity=34.2036553524804, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789386, Length=309, Percent_Identity=26.537216828479, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=24.4949494949495, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=383, Percent_Identity=55.6135770234987, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24657991, Length=423, Percent_Identity=24.5862884160757, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40311; Mature: 40179

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSTFFIPSVNVIGADSLTDAMNMMADYGFTRTLIVTDSMLTKLGMAGDVQKALEERNI
CCCCEEECCCCCEECCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCHHHHHHHHHCCE
FSVIYDGTQPNPTTENVAAGLKLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
IGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVNVTGKNDAEGAEACINAIRELAKKVDIPAGLRDLNVKEEDFAVLAANALKD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ACGFTNPIQATHEEIVAIYRAAM
HHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASSTFFIPSVNVIGADSLTDAMNMMADYGFTRTLIVTDSMLTKLGMAGDVQKALEERNI
CCCEEECCCCCEECCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCHHHHHHHHHCCE
FSVIYDGTQPNPTTENVAAGLKLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
IGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVNVTGKNDAEGAEACINAIRELAKKVDIPAGLRDLNVKEEDFAVLAANALKD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ACGFTNPIQATHEEIVAIYRAAM
HHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]