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The map label for this gene is fghA1 [H]

Identifier: 209400188

GI number: 209400188

Start: 3020265

End: 3021101

Strand: Direct

Name: fghA1 [H]

Synonym: ECH74115_3289

Alternate gene names: 209400188

Gene position: 3020265-3021101 (Clockwise)

Preceding gene: 209399775

Following gene: 209395763

Centisome position: 54.2

GC content: 54.36

Gene sequence:

>837_bases
ATGGAAATGCTCGAAGAGCACCGCTGTTTTGAAGGCTGGCAGCAACGCTGGCGACACGACTCCAGTACCTTAAACTGCCC
GATGACGTTCAGTATCTTTCTCCCACCCCCTCGTGATCACACCCCGCCACCAGTGCTGTACTGGCTTTCCGGATTAACCT
GCAATGACGAGAACTTCACCACCAAGGCGGGTGCCCAGCGCGTGGCGGCGGAACTGGGGATTGTACTGGTTATGCCAGAC
ACCAGCCCGCGCGGCGAAAAGGTTGCCAACGACGATGGCTACGATTTAGGCCAGGGCGCAGGCTTTTATCTTAATGCCAC
GCAACCGCCGTGGGCGACGCATTACCGGATGTATGATTATCTGCGTGATGAATTACCGGCGCTGGTTCAGTCGCAATTTA
ATGTCAGCGACCGCTGCGCTATTAGCGGTCATTCAATGGGTGGTCACGGTGCGCTGATTATGGCGCTGAAAAACCCGGGC
AAATACACCAGCGTTTCGGCCTTTGCGCCAATTGTGAATCCGTGCAGCGTCCCGTGGGGAATCAAAGCGTTTAGCCGCTA
TTTAGGTGAGGACAAAAATGCATGGCTGGAATGGGACAGTTGCGCGCTGATGTATGCCAGTAACGCGCAGGATGCGATCC
CGACGCTTATCGATCAGGGTGATAACGATCAGTTTCTTGCTGACCAACTGCAACCTGCAGTACTTGCAGAAGCCGCGCGC
CAGAAAGCATGGCCGATGACGCTGCGTATTCAGCCGGGATATGATCACAGTTACTACTTCATCGCCTCTTTTATAGAGGA
TCACCTGCGCTTCCATGCGCAGTATTTACTGAAGTGA

Upstream 100 bases:

>100_bases
TAAAACATCGTTATGCAAATACGGAAGTGAAAGTTACTCACAGCACATTGAATAAACGGTATGATGAAGAAATTGCAAAC
AACACAACAAGGAGCCACGC

Downstream 100 bases:

>100_bases
AAGTCCGCCCGGTTCGCCGGGCATCTTCTCATCAGAAGCGATAATCCACTGCCATAAAGTAACGACGTCCGTCTTCGTTA
TAGCTGTAGTCGTCACGACT

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPCSVPWGIKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK

Sequences:

>Translated_278_residues
MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPCSVPWGIKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
>Mature_278_residues
MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPD
TSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPG
KYTSVSAFAPIVNPCSVPWGIKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=279, Percent_Identity=52.6881720430108, Blast_Score=303, Evalue=1e-82,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=99.6402877697842, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=53.6231884057971, Blast_Score=319, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=45.7142857142857, Blast_Score=243, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=44.4444444444444, Blast_Score=238, Evalue=9e-64,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=50.1766784452297, Blast_Score=267, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=50.1766784452297, Blast_Score=267, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31329; Mature: 31329

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFT
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEECCCCCC
TKAGAQRVAAELGIVLVMPDTSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWG
HHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCC
IKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHH
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFT
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEECCCCCC
TKAGAQRVAAELGIVLVMPDTSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDY
CHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
LRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWG
HHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCC
IKAFSRYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAAR
HHHHHHHHCCCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHH
QKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA