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The map label for this gene is cusC

Identifier: 209399978

GI number: 209399978

Start: 681535

End: 682917

Strand: Direct

Name: cusC

Synonym: ECH74115_0653

Alternate gene names: 209399978

Gene position: 681535-682917 (Clockwise)

Preceding gene: 209399226

Following gene: 209396059

Centisome position: 12.23

GC content: 51.41

Gene sequence:

>1383_bases
ATGTCTCCTTGTAAACTTCTGCCATTTTGTGTGGCCCTTGCGCTAACCGGTTGTTCACTGGCACCGGATTATCAGCGCCC
GGCAATGCCCGTACCGCAGCAGTTCTCACTCAGCCAGAACGGCCTGGTTAACGCAGCAGATAACTATCAGAACGCGGGCT
GGCGCACCTTTTTTGTTGATAATCAGGTGAAGACGCTGATTAGCGAGGCGCTGGAGAATAACCGGGATTTGCGCATGGCG
ACGCTGAAAGTGCAGGAGGCACGGGCGCAATATCGTCTGACTGATGCCGACCGCTACCCACAGCTCAATGGTGAGGGCAG
CGGCAGCTGGAGCGGCAATCTTAAAGGCGATTCAGCCACGACGCGGGAGTTTTCTACTGGCCTTAACGCCAGCTTTGACC
TCGATTTTTTCGGGCGCTTAAAGAACATGAGCGAAGCCGAGCGACAAAATTATTTAGCCACTGAGGAAGCTCAGCGCGCG
GTGCATATTCTGCTGGTTTCTAATGTCGCGCAAAGCTATTTCAATCAGCAGCTGGCGTATGCGCAATTGCAAATAGCCGA
AGAAACGCTGCGTAATTATCAGCAGTCATATGCGTTTGTCGAAAAACAACTGTTGACAGGTAGCAGTAATGTTCTGGCGC
TGGAACAGGCTCGCGGGGTGATTGAAAGTACCCGCAGCGACATCGCTAAACGTCAGGGGGAACTGGCGCAGGCGAATAAT
GCATTGCAACTGTTACTGGGAAGCTACGGCAAGCTGCCGCAAGCGCAGACAGTAAACAGCGACAGCCTGCAAAGCGTTAA
ATTACCGGCGGGCTTGTCGTCGCAAATCTTATTGCAGCGCCCGGATATTATGGAAGCTGAACATGCGTTAATGGCGGCTA
ATGCCAATATTGGTGCTGCACGCGCGGCATTTTTCCCGTCTATCAGCCTGACCAGCGGAATATCAACCGCCAGCAGCGAT
CTGTCGTCATTATTTAACGCCAGCAGCGGGATGTGGAATTTTATTCCTAAAATTGAGATCCCCATTTTTAATGCCGGACG
CAACCAGGCCAATCTGGATATCGCCGAAATTCGCCAGCAGCAGTCGGTAGTGAATTATGAACAGAAAATCCAGAACGCCT
TTAAAGAAGTGGCAGATGCGCTGGCATTACGTCAAAGCCTGAACGATCAAATTAGCGCCCAGCAGCGTTATCTGGCATCG
CTGCAAATTACTTTGCAACGGGCGCGGGCATTATATCAGCACGGCGCAGTAAGTTATCTGGAAGTGCTGGATGCCGAGCG
TTCTTTATTTGCAACCCGACAAACCGTACTTGACCTGAATTATGCCCGTCAGGTCAACGAAATTTCTTTATATACCGCAC
TTGGTGGCGGTTGGCAGCAATAA

Upstream 100 bases:

>100_bases
CTTATTGGCAAAATGACAATTTTGTCATTTTCCTGTCACCGGAAAATCAGAGCCTGGCGAGTAAAGTTGGCGGTATAAAA
TCACCAGAAATTATGAGCCT

Downstream 100 bases:

>100_bases
TTTTTAACTCCAGGAGAAAATAAATGAAAAAAGCACTGCAAGTCGCAATGTTCAGTCTGTTTACCGTTATTGGCTTTAAT
GCCCAGGCTAACGAACATCA

Product: copper/silver efflux system outer membrane protein CusC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNAGWRTFFVDNQVKTLISEALENNRDLRMA
TLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDLDFFGRLKNMSEAERQNYLATEEAQRA
VHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQANN
ALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTASSD
LSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLAS
LQITLQRARALYQHGAVSYLEVLDAERSLFATRQTVLDLNYARQVNEISLYTALGGGWQQ

Sequences:

>Translated_460_residues
MSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNAGWRTFFVDNQVKTLISEALENNRDLRMA
TLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDLDFFGRLKNMSEAERQNYLATEEAQRA
VHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQANN
ALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTASSD
LSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLAS
LQITLQRARALYQHGAVSYLEVLDAERSLFATRQTVLDLNYARQVNEISLYTALGGGWQQ
>Mature_459_residues
SPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNAGWRTFFVDNQVKTLISEALENNRDLRMAT
LKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDLDFFGRLKNMSEAERQNYLATEEAQRAV
HILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQANNA
LQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTASSDL
SSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASL
QITLQRARALYQHGAVSYLEVLDAERSLFATRQTVLDLNYARQVNEISLYTALGGGWQQ

Specific function: Part of a cation efflux system that mediates resistance to copper and silver

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family

Homologues:

Organism=Escherichia coli, GI1786785, Length=457, Percent_Identity=99.1247264770241, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI2367348, Length=462, Percent_Identity=26.8398268398268, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CUSC_ECO57 (Q8XBY3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B90705
- PIR:   E85555
- RefSeq:   NP_286297.1
- RefSeq:   NP_308637.1
- ProteinModelPortal:   Q8XBY3
- SMR:   Q8XBY3
- EnsemblBacteria:   EBESCT00000025201
- EnsemblBacteria:   EBESCT00000055338
- GeneID:   916968
- GeneID:   957569
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0711
- KEGG:   ecs:ECs0610
- GeneTree:   EBGT00050000009375
- HOGENOM:   HBG759011
- OMA:   QEAMIRD
- ProtClustDB:   PRK09837
- BioCyc:   ECOL83334:ECS0610-MONOMER
- InterPro:   IPR003423
- InterPro:   IPR010131
- TIGRFAMs:   TIGR01845

Pfam domain/function: PF02321 OEP

EC number: NA

Molecular weight: Translated: 50716; Mature: 50584

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNAGWRTFFVD
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEC
NQVKTLISEALENNRDLRMATLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDSAT
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TREFSTGLNASFDLDFFGRLKNMSEAERQNYLATEEAQRAVHILLVSNVAQSYFNQQLAY
HHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQANN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHCH
ALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAA
HHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHHHHHHHHCCCCCCCHH
RAAFFPSISLTSGISTASSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQ
HHHHCCCCHHHCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHH
QSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVLDAERSLFATRQTVLDLNYARQVNEISLYTALGGGWQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure 
SPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGLVNAADNYQNAGWRTFFVD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEC
NQVKTLISEALENNRDLRMATLKVQEARAQYRLTDADRYPQLNGEGSGSWSGNLKGDSAT
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TREFSTGLNASFDLDFFGRLKNMSEAERQNYLATEEAQRAVHILLVSNVAQSYFNQQLAY
HHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQANN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHCH
ALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAA
HHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHHHHHHHHCCCCCCCHH
RAAFFPSISLTSGISTASSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQ
HHHHCCCCHHHCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHH
QSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EVLDAERSLFATRQTVLDLNYARQVNEISLYTALGGGWQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796