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The map label for this gene is prc [H]

Identifier: 209399862

GI number: 209399862

Start: 2420892

End: 2422934

Strand: Reverse

Name: prc [H]

Synonym: ECH74115_2563

Alternate gene names: 209399862

Gene position: 2422934-2420892 (Counterclockwise)

Preceding gene: 209399115

Following gene: 209400608

Centisome position: 43.48

GC content: 49.98

Gene sequence:

>2043_bases
ATGTTTTTTAGGCTTACCGCGTTAGCTGGCCTGCTTGCAATAGCAGGCCAGACCTTCGCTGTAGAAGATATCACGCGTGC
TGATCAAATTCCGGTATTAAAGGAAGAGACGCAGCATGCGACGGTGAGTGAGCGCGTAACGTCGCGCTTCACCCGTTCTC
ATTATCGCCAGTTCGACCTCGATCAGGCATTTTCGGCCAAAATCTTTGACCGCTACCTGAATCTGCTCGATTACAGCCAC
AACGTGCTGCTGGCAAGCGATGTTGAACAGTTCGCGAAAAAGAAAACCGAGTTAGGCGATGAACTGCGTTCAGGCAAACT
CGACGTTTTCTACGATCTCTACAATCTGGCGCAAAAGCGTCGTTTTGAACGTTACCAATACGCTTTGTCGGTACTGGAAA
AGCCGATGGATTTCACCGGCAACGACACTTATAACCTTGACCGCAGCAAAGCGCCCTGGCCGAAAAACGAGGCTGAGTTG
AACGCGCTGTGGGACAGTAAAGTCAAATTCGACGAGTTAAGCCTGAAGCTGGCAGGAAAAACGGATAAAGAAATTCGTGA
AACCCTGACTCGCCGCTACAAATTTGCCATTCGTCGTCTGGCGCAAACCAACAGCGAAGATGTTTTCTCGCTGGCAATGA
CGGCGTTTGCGCGTGAAATCGACCCGCATACCAACTATCTTTCCCCGCGTAATACCGAACAGTTCAACACTGAAATGAGT
TTGTCGCTGGAAGGTATTGGCGCAGTGCTGCAAATGGATGATGACTACACCGTTATCAATTCGATGGTGGCAGGTGGTCC
GGCAGCGAAGAGTAAAGCTATCAGCGTTGGTGACAAAATTGTCGGTGTTGGTCAAACAGGCAAGCCGATGGTTGACGTGA
TTGGCTGGCGTCTTGATGATGTGGTTGCCTTAATTAAAGGGCCGAAGGGCAGTAAAGTTCGTCTGGAAATTTTACCTGCT
GGTAAAGGGACCAAGACCCGCACTGTAACATTGACCCGTGAACGTATTCGTCTCGAAGACCGCGCGGTTAAAATGTCGGT
GAAGACCGTCGGTAAAGAGAAAGTCGGCGTGCTGGATATTCCTGGCTTCTATGTGGGTTTGACAGACGATGTCAAAGTGC
AACTGCAGAAACTGGAAAAACAGAATGTCAGCAGTGTGATCATCGATCTGCGTAGCAATGGTGGTGGGGCGCTGACCGAA
GCGGTATCGCTCTCAGGTCTGTTTATTCCTGCGGGTCCTATTGTTCAGGTCCGTGATAACAACGGTAAAGTTCGTGAAGA
CAGCGATACCGACGGACAGGTTTTCTATAAAGGCCCGCTGGTGGTACTGGTTGACCGCTTCAGTGCTTCGGCTTCAGAAA
TCTTTGCCGCGGCAATGCAGGATTACGGTCGTGCACTGGTTGTGGGTGAACCGACGTTTGGTAAAGGCACCGTTCAGCAA
TACCGTTCATTGAACCGTATTTACGATCAGATGTTACGTCCTGAATGGCCAGCGCTGGGTTCTGTGCAGTACACGATCCA
GAAATTCTATCGCGTTAACGGCGGCAGTACGCAACGTAAAGGCGTAACGCCAGACATCATCATGCCGACGGGTAATGAAG
AAACGGAAACGGGTGAGAAATTCGAAGATAACGCGCTGCCGTGGGATAGCATTGATGCCGCGACTTATGTGAAATCAGGC
GATTTAACGGCCTTTGAACCGGAGCTACTGAAGGAACATAATGCGCGTATCGCGAAAGATCCTGAGTTCCAGAACATCAT
GAAGGATATCGCGCGCTTCAACGCTATGAAGGACAAGCGCAATATCGTTTCTCTGAATTACGCTGTGCGTGAGAAAGAGA
ATAATGAAGATGATGCGACGCGTTTGGCGCGTTTGAACGAACGCTTTAAACGCGAAGGTAAACCGGAGTTGAAGAAACTG
GATGATCTACCGAAAGATTACCAGGAGCCGGATCCTTATCTGGATGAGACGGTGAATATCGCACTCGATCTGGCGAAGCT
TGAAAAAGCCAGACCCGCGGAACAACCCGCACCCGTCAAGTAA

Upstream 100 bases:

>100_bases
ACCAAAGACGGCGTCCGCGTCCAGCTGAATTCGGGTATGTCTTTGATTGTGCGCGCAGAACACCTGGTGTTCTGAAACGG
AGGCCGGGCCAGGCATGAAC

Downstream 100 bases:

>100_bases
TATCAATCAGGCACAAGAAATTGTGCCTGATTTTTTAACAGCGGCAAGATGCCGTAAATCAGATGCTACAAAATGTAAAG
TTGTGTCTTTCTGGTGACTT

Product: carboxy-terminal protease

Products: NA

Alternate protein names: C-terminal-processing peptidase; PRC protein; Protease Re [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDYSH
NVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAEL
NALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTEMS
LSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEILPA
GKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTE
AVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTVQQ
YRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVKSG
DLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKL
DDLPKDYQEPDPYLDETVNIALDLAKLEKARPAEQPAPVK

Sequences:

>Translated_680_residues
MFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDYSH
NVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAEL
NALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTEMS
LSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEILPA
GKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTE
AVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTVQQ
YRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVKSG
DLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKL
DDLPKDYQEPDPYLDETVNIALDLAKLEKARPAEQPAPVK
>Mature_680_residues
MFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDYSH
NVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAEL
NALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTEMS
LSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEILPA
GKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTE
AVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTVQQ
YRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVKSG
DLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKL
DDLPKDYQEPDPYLDETVNIALDLAKLEKARPAEQPAPVK

Specific function: Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses [H]

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=680, Percent_Identity=99.8529411764706, Blast_Score=1387, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR020992 [H]

Pfam domain/function: PF11818 DUF3340; PF00595 PDZ; PF03572 Peptidase_S41 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 76389; Mature: 76389

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDL
CEEEHHHHHHHHHHCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQAFSAKIFDRYLNLLDYSHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKR
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAELNALWDSKVKFDELSLKLAGK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEHEEEEECCC
TDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTEMS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCEEE
LSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDD
EEECCCCEEEEECCCHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCHHHHHCCCHHH
VVALIKGPKGSKVRLEILPAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDI
HHHHHCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHEEHHHHCCCCCCCEEEC
PGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTEAVSLSGLFIPAGPIVQVRDN
CCEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCEEEECCCCEEEEECC
NGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTVQQ
CCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
YRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEK
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCC
FEDNALPWDSIDAATYVKSGDLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKR
CCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
NIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKLDDLPKDYQEPDPYLDETVNI
CEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCCHHHHHHH
ALDLAKLEKARPAEQPAPVK
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDL
CEEEHHHHHHHHHHCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQAFSAKIFDRYLNLLDYSHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKR
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAELNALWDSKVKFDELSLKLAGK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEHEEEEECCC
TDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTEMS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCEEE
LSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDD
EEECCCCEEEEECCCHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCHHHHHCCCHHH
VVALIKGPKGSKVRLEILPAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDI
HHHHHCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHEEHHHHCCCCCCCEEEC
PGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTEAVSLSGLFIPAGPIVQVRDN
CCEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCEEEECCCCEEEEECC
NGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTVQQ
CCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
YRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEK
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCC
FEDNALPWDSIDAATYVKSGDLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKR
CCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
NIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKLDDLPKDYQEPDPYLDETVNI
CEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCCCCHHHHHHH
ALDLAKLEKARPAEQPAPVK
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856173; 1729701; 9097040; 9278503; 1447154; 10049386; 7499412; 8576225 [H]