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The map label for this gene is yjcC [H]

Identifier: 209399666

GI number: 209399666

Start: 5203818

End: 5205404

Strand: Direct

Name: yjcC [H]

Synonym: ECH74115_5564

Alternate gene names: 209399666

Gene position: 5203818-5205404 (Clockwise)

Preceding gene: 209397137

Following gene: 209397033

Centisome position: 93.39

GC content: 44.55

Gene sequence:

>1587_bases
ATGAATCATCGTGCACGACACCAATTACTGGCGTTGCCGGGCATTATCTTTTTAGTTCTCTTTCCCATCATTCTTTCGCT
ATGGATTGCCTTCCTTTGGGCAAAATCAGAAGTGAATAATCAGCTCCGAACCTTTGCTCAACTGGCGTTGGATAAATCCG
AGCTGGTCATTCGCCAGGCAGATTTAGTGAGCGATGCAGCTGAACGCTATCAGGGGCAAGTTTGCACTCCAGCCCATCAA
AAGCGAATGTTGAATATTATTCGTGGCTATCTTTATATTAATGAATTGATCTATGCCCGTGATAATCATTTTTTATGCTC
ATCGCTGATAGTGCCTGTAAACGGCTATACGATTGTATCGGCCGATTATAAGCGTGAACCTAATGTTTCTATCTATTATT
ACCGCGATACGCCTTTTTTCTCTGGCTATAAAATGACCTATATGCAGCGGGGAAATTATGTGGCGGTTATCAACCCTCTC
TTCTGGAGTGAAGTGATGTCTGATGACCCGACATTGCAATGGGGTGTGTATGATACGGTGACGAAAACCTTTTTCTCGTT
AAGCAAAGAGGCCTCAGCAGCAACGTTTTCTCCGCTGATTCATTTGAAGGATTTAACCGTACCAAGAAATGGCTATTTAT
ATGCGACAGTTTATTCGACAAAACGCCCAATTGTAGCCATTGTTGCGACTTCATATCAACGTCTTATAGCCCATTTTTAT
AATCATCTTATTTTTGCGTTGCCCGCCGGTATTTTGGGGAGTCTTGTTCTGCTATTACTCTGGCTACGTATTCGACAAAA
CTATTTGTCTCCCAAACGCAAATTGCAACGCGCCCTCGAAAAACATCAGCTATGCCTTTATTACCAGCCAATAATTGATA
TCAAAACAGAAAAATGTATCGGCGCTGAAGCGTTGTTACGTTGGCCTGGTGAGCAGGGGCAAGTAATGAATCCGGCAGAG
TTTATTCCTCTGGCAGAAAAGGAGGGGATGATAGAACAGGTAACTGATTATGTTATTGATAATGTCTTCCGCGATCTGGG
CGCGTACCTTGCAACACATGCTGATCGCTATGTTTCTATTAATCTGTCGGCCTCCGATTTTCATACGTCACGGTTGATAG
CGCGAATCAATCAGAAAACAGAGCAATACGCGGTGCGTCCGCAGCAAATTAAATTTGAAGTGACTGAGCATGCATTTCTT
GATGTCGACAAAATGACGCCGATTATTCTGGCTTTCCGCCAGGCTGGTTACGAAGTGGCAATTGATGATTTTGGTATTGG
CTACTCTAACTTGCATAACCTTAAATCATTGAATGTCGATATTTTGAAAATCGACAAATCGTTTGTTGAGACGCTGACCA
CCCATAAAACCAGTCATTTGATTGCTGAACATATCATCGAGCTGGCGCACAGCCTGGGGTTAAAAACGATCGCTGAAGGC
GTCGAAACTGAGGAGCAGGTTAACTGGCTGCGCAAACGCGGCGTGCGCTATTGCCAGGGATGGTTCTTTGCGAAGGCGAT
GCCGCCGCAGGTGTTTATGCAATGGATGGAGCAATTACCCGCGCGGGAGTTAACGCGCGGGCAATAA

Upstream 100 bases:

>100_bases
GCAAAAGTGCTATTTATACCGTAAGATTTATCTAAAGACGTCGGTAGCCAGGGTTTCACCTTGCAATGGCCGGGTATAAA
CAGGCAGGAAATTGATAGCA

Downstream 100 bases:

>100_bases
AACTACAGGCGGTGGCGATAATCGCTGGGAGTGCGATCAAACTGCCGACGGAAAACGCGGGAGAAGGTCTGCTGAGAGAC
ATAACCCAGGTCCATTGCGA

Product: cyclic diguanylate phosphodiesterase (EAL) domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MNHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQ
KRMLNIIRGYLYINELIYARDNHFLCSSLIVPVNGYTIVSADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPL
FWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVPRNGYLYATVYSTKRPIVAIVATSYQRLIAHFY
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWPGEQGQVMNPAE
FIPLAEKEGMIEQVTDYVIDNVFRDLGAYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFL
DVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ

Sequences:

>Translated_528_residues
MNHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQ
KRMLNIIRGYLYINELIYARDNHFLCSSLIVPVNGYTIVSADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPL
FWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVPRNGYLYATVYSTKRPIVAIVATSYQRLIAHFY
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWPGEQGQVMNPAE
FIPLAEKEGMIEQVTDYVIDNVFRDLGAYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFL
DVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
>Mature_528_residues
MNHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQ
KRMLNIIRGYLYINELIYARDNHFLCSSLIVPVNGYTIVSADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPL
FWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVPRNGYLYATVYSTKRPIVAIVATSYQRLIAHFY
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWPGEQGQVMNPAE
FIPLAEKEGMIEQVTDYVIDNVFRDLGAYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFL
DVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ

Specific function: Overexpression reduces biofilm formation [H]

COG id: COG4943

COG function: function code T; Predicted signal transduction protein containing sensor and EAL domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI1790496, Length=528, Percent_Identity=98.1060606060606, Blast_Score=1081, Evalue=0.0,
Organism=Escherichia coli, GI87081743, Length=522, Percent_Identity=33.3333333333333, Blast_Score=295, Evalue=7e-81,
Organism=Escherichia coli, GI1788502, Length=536, Percent_Identity=26.3059701492537, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI87081980, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081845, Length=279, Percent_Identity=31.8996415770609, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI226510982, Length=251, Percent_Identity=38.2470119521912, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081921, Length=244, Percent_Identity=36.4754098360656, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1787541, Length=249, Percent_Identity=32.5301204819277, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1788849, Length=236, Percent_Identity=30.9322033898305, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786507, Length=242, Percent_Identity=31.404958677686, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87082096, Length=235, Percent_Identity=31.063829787234, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=30.7086614173228, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1787410, Length=225, Percent_Identity=28.4444444444444, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: NA

Molecular weight: Translated: 60770; Mature: 60770

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
DLVSDAAERYQGQVCTPAHQKRMLNIIRGYLYINELIYARDNHFLCSSLIVPVNGYTIVS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHEEECCCEEEEE
ADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLFWSEVMSDDPTLQWGVYDTV
ECCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECHHHHHHHHCCCCCEEECHHHHH
TKTFFSLSKEASAATFSPLIHLKDLTVPRNGYLYATVYSTKRPIVAIVATSYQRLIAHFY
HHHHHHHHCCCCCHHHHHHEEEEECCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHH
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCHHCCCCCHHC
GAEALLRWPGEQGQVMNPAEFIPLAEKEGMIEQVTDYVIDNVFRDLGAYLATHADRYVSI
CHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLDVDKMTPIILAFRQAGYEVA
EECCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHHHEEHHHCCHHHHHHHHCCCEEE
IDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
EECCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
CCHHHHHHHHHHCCHHHHHCCHHHCCCCHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MNHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
DLVSDAAERYQGQVCTPAHQKRMLNIIRGYLYINELIYARDNHFLCSSLIVPVNGYTIVS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHEEECCCEEEEE
ADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLFWSEVMSDDPTLQWGVYDTV
ECCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECHHHHHHHHCCCCCEEECHHHHH
TKTFFSLSKEASAATFSPLIHLKDLTVPRNGYLYATVYSTKRPIVAIVATSYQRLIAHFY
HHHHHHHHCCCCCHHHHHHEEEEECCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHH
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCHHCCCCCHHC
GAEALLRWPGEQGQVMNPAEFIPLAEKEGMIEQVTDYVIDNVFRDLGAYLATHADRYVSI
CHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLDVDKMTPIILAFRQAGYEVA
EECCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHHHEEHHHCCHHHHHHHHCCCEEE
IDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
EECCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
CCHHHHHHHHHHCCHHHHHCCHHHCCCCHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]