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The map label for this gene is argC

Identifier: 209399663

GI number: 209399663

Start: 5064751

End: 5065755

Strand: Direct

Name: argC

Synonym: ECH74115_5418

Alternate gene names: 209399663

Gene position: 5064751-5065755 (Clockwise)

Preceding gene: 209396067

Following gene: 209398952

Centisome position: 90.9

GC content: 53.53

Gene sequence:

>1005_bases
ATGTTGAATACGCTGATTGTGGGTGCCAGCGGCTACGCTGGCGCAGAGCTAGTGACCTGTGTAAATCGCCATCCGCATAT
GAACATAACCGCTTTGACTGTTTCAGCGCAAAGCAATGATGCGGGAAAGTTAATCTCCGATTTGCATCCGCAGCTAAAAG
GCATCGTTGATCTGCCGTTGCAGCCGATGTCGGATATCAGCGAGTTTAGCCCTGGGGTGGACGTGGTGTTTCTCGCCACC
GCCCATGAAGTTAGCCACGATTTAGCGCCGCAGTTTCTTGACGCGGGCTGCGTGGTGTTCGACCTTTCCGGCGCGTTTCG
TGTTAACGACGCCACCTTCTATGAAAAATATTACGGCTTTACCCATCAATACCCGGAACTGCTGGAACAGGCAGCCTACG
GTCTGGCGGAGTGGTGCGGTAATAAATTAAAAGAAGCGAATTTGATTGCGGTGCCAGGCTGTTATCCGACGGCAGCACAG
TTGGCGCTGAAACCGTTGATTGATGCCGATCTTCTTGACCTCAATCAGTGGCCGGTGATCAACGCCACCAGCGGCGTGAG
CGGTGCAGGACGTAAGGCAGCGATTTCAAATAGTTTTTGTGAAGTTAGCCTGCAACCGTATGGCGTCTTTACCCATCGCC
ATCAACCAGAGATCGCCACACACCTCGGTGCTGACGTTATCTTCACCCCGCATCTGGGCAATTTCCCGCGCGGCATTCTC
GAAACCATTACCTGCCGCCTGAAACCGGGTGTGACCCAGGCGCAAGTGGCGCAAGCGTTACAGCAGGCGTATGCCCATAA
ACCGCTGGTGCGGCTGTATGACAAAGGCGTTCCGGCGCTGAAAAATGTCGTTGGGCTACCATTTTGCGATATCGGGTTTG
CCGTTCAGGGCGAACATCTGATTATTGTGGCGACCGAAGACAACTTACTGAAAGGCGCGGCGGCACAAGCGGTACAGTGC
GCCAATATTCGTTTCGGCTATGCGGAAACGCAGTCTCTTATTTAA

Upstream 100 bases:

>100_bases
TAAAAATACACTAACGTTGAGCGTAATAAAACCCACCAGCCGTAAGGTGAATGTTTTACGTTTAACCTGGCAACCAGACA
TAAGAAGGTGAATAGCCCCG

Downstream 100 bases:

>100_bases
GGGTGCAATGATGAATCCATTAATTATCAAACTGGGTGGCGTACTGCTGGATAGTGAAGAGGCGCTGGAACGTCTGTTTA
GCGCACTGGTGAATTATCGT

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLNTLIVGASGYAGAELVTCVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLAT
AHEVSHDLAPQFLDAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQ
LALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGIL
ETITCRLKPGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQC
ANIRFGYAETQSLI

Sequences:

>Translated_334_residues
MLNTLIVGASGYAGAELVTCVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLAT
AHEVSHDLAPQFLDAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQ
LALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGIL
ETITCRLKPGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQC
ANIRFGYAETQSLI
>Mature_334_residues
MLNTLIVGASGYAGAELVTCVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLAT
AHEVSHDLAPQFLDAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQ
LALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGIL
ETITCRLKPGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQC
ANIRFGYAETQSLI

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=334, Percent_Identity=98.8023952095808, Blast_Score=677, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320913, Length=332, Percent_Identity=29.2168674698795, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_ECO57 (Q8X732)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D86087
- PIR:   G91239
- RefSeq:   NP_290595.1
- RefSeq:   NP_312914.1
- ProteinModelPortal:   Q8X732
- SMR:   Q8X732
- EnsemblBacteria:   EBESCT00000024805
- EnsemblBacteria:   EBESCT00000056216
- GeneID:   914990
- GeneID:   960174
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5516
- KEGG:   ecs:ECs4887
- GeneTree:   EBGT00050000009043
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- ProtClustDB:   PRK00436
- BioCyc:   ECOL83334:ECS4887-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 35860; Mature: 35860

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01224 ARGC; PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTLIVGASGYAGAELVTCVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPL
CCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHHCCCCCCC
QPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLDAGCVVFDLSGAFRVNDATFYEKYYGF
CCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCEEECCHHHHHHHCCC
THQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVI
CCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHCCCCCCEE
NATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGIL
ECCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHHCCCCEEECCCCCCCCHHHH
ETITCRLKPGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHL
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCCEECCCEEECCCEE
IIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI
EEEECCCCHHHHHHHHHEEHHCEEECCHHHHCCC
>Mature Secondary Structure
MLNTLIVGASGYAGAELVTCVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPL
CCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHHCCCCCCC
QPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLDAGCVVFDLSGAFRVNDATFYEKYYGF
CCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCEEECCHHHHHHHCCC
THQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVI
CCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHCCCCCCEE
NATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGIL
ECCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHHCCCCEEECCCCCCCCHHHH
ETITCRLKPGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHL
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCCEECCCEEECCCEE
IIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI
EEEECCCCHHHHHHHHHEEHHCEEECCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796