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The map label for this gene is aprE [H]

Identifier: 209399564

GI number: 209399564

Start: 607251

End: 608426

Strand: Direct

Name: aprE [H]

Synonym: ECH74115_0585

Alternate gene names: 209399564

Gene position: 607251-608426 (Clockwise)

Preceding gene: 209400615

Following gene: 209399114

Centisome position: 10.9

GC content: 56.8

Gene sequence:

>1176_bases
ATGAACGGACAACTGCAATATAACCGTGGTCTGACTGAACCCCGCCTGCCGCGTTCGGCGCTGGCGGTACGCGTTACCGC
TGTGATGCTGCTCTGTTTTCTCGGCTGGGCGTGGTACTTCCAGCTTGATGAAGTCACCACCGGCAGCGGCACGGTAGAAC
CTTCCGGGCGCGAACAGGTGGTGCAGTCGCTGGAAGGCGGAATTCTGTATCATCTCGACGTGAAAGTTGGCGATATTGTC
GAACAGGGCCAGCCGCTGGCGCAGCTTAACCGCACCAAAACGGAATCCGACGTCCAGGAAGCGATGTCGCGGCTGTACGC
GGCGCTGGCAACCTCGGCGCGGCTGCGGGCGGAAGTGAGCAATAAACCGCTGGTCTTCCCTGACGAACTGAATAAATTCC
CCGAACTTATCGAGTCGGAAACGGCGTTGTACAACACTCGCCGCGACGGGTTGAACAAAGCCACCACCGGGCTGACGCAG
GGGATTAGCCTGGTCAATCGCGAACTGGCGATGACCCAGCCGCTGGTAAAACAGGGGGCAGCGAGCAGCGTCGAAGTACT
GCGCCTGCAACGCCAGGCCAATGAACTGGAAAACAAACTCAGCGACGTGCGCACGCAATACTACGTTCAGGCGCGCGAAG
AGTTAGCAAAAGCCAATGCGGAAGTGGAAACCCAGCGTTCGGTGATCCGTGGACGGGAAGACTCTCTCACCAGGCTCAAC
TTTACCGCGCCGGTGCGAGGCATTGTTCAGGATATTGATGTCACCACGGTTGGCGGCGTCATCGCCCCCGGTGGTAAACT
GATGACCATCGTGCCGCTGGATGAGCAACTGCTGATTGAGGCAAAAATCTCCCCGCGCGATGTGGCGTTTATCCACCCGG
GGCAAAAATCGCTGGTGAAAATAACTGCCTACGATTACTCCATCTACGGCGGCCTGCCGGGAGAAGTGGCGGTGATATCA
CCAGACACCGTGCAGGATGAAGTGCGGCGCGATGTTTATTACTATCGGGTGTACATTCGCACTTTCAGCAACCATCTGGA
AAACAAAAGCAAACAGCAGTTTCCGATATTCCCCGGTATGGTGGCGACGGTCGATATCCGCACCGGCAAAAAAAGCGTGC
TGGATTATCTGTTGAAACCCTTTAACAAAGCACAGGAGGCGTTGCGCGAACGATGA

Upstream 100 bases:

>100_bases
GGATTGTGATGGACGGCGCGAAAGAGGCCATTTTGCGTGAACAGGGCGAGCCCACAGCGCGACGGGTGGTGTTGCAGGAG
AAGAATAAGGGGTCTGCGGC

Downstream 100 bases:

>100_bases
ACATTAGCGATGTAGCAAAAATTACCGGCCTGACCAGCAAAGCCATTCGCTTCTATGAAGAGAAGGGGCTGGTGACGCCG
CCGATGCGCAGCGAAAATGG

Product: membrane spanning export protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNGQLQYNRGLTEPRLPRSALAVRVTAVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQVVQSLEGGILYHLDVKVGDIV
EQGQPLAQLNRTKTESDVQEAMSRLYAALATSARLRAEVSNKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQ
GISLVNRELAMTQPLVKQGAASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETQRSVIRGREDSLTRLN
FTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEQLLIEAKISPRDVAFIHPGQKSLVKITAYDYSIYGGLPGEVAVIS
PDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGMVATVDIRTGKKSVLDYLLKPFNKAQEALRER

Sequences:

>Translated_391_residues
MNGQLQYNRGLTEPRLPRSALAVRVTAVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQVVQSLEGGILYHLDVKVGDIV
EQGQPLAQLNRTKTESDVQEAMSRLYAALATSARLRAEVSNKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQ
GISLVNRELAMTQPLVKQGAASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETQRSVIRGREDSLTRLN
FTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEQLLIEAKISPRDVAFIHPGQKSLVKITAYDYSIYGGLPGEVAVIS
PDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGMVATVDIRTGKKSVLDYLLKPFNKAQEALRER
>Mature_391_residues
MNGQLQYNRGLTEPRLPRSALAVRVTAVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQVVQSLEGGILYHLDVKVGDIV
EQGQPLAQLNRTKTESDVQEAMSRLYAALATSARLRAEVSNKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQ
GISLVNRELAMTQPLVKQGAASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETQRSVIRGREDSLTRLN
FTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEQLLIEAKISPRDVAFIHPGQKSLVKITAYDYSIYGGLPGEVAVIS
PDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGMVATVDIRTGKKSVLDYLLKPFNKAQEALRER

Specific function: Involved in the secretion of alkaline protease [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43629; Mature: 43629

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGQLQYNRGLTEPRLPRSALAVRVTAVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQV
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHH
VQSLEGGILYHLDVKVGDIVEQGQPLAQLNRTKTESDVQEAMSRLYAALATSARLRAEVS
HHHHCCCEEEEEECCHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQGISLVNRELAMTQPLVKQGA
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETQRSVIRGREDSLTRLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEE
FTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEQLLIEAKISPRDVAFIHPGQKSLVK
CCCHHHHHHHHCCEEEECCEECCCCCEEEEEECCCEEEEEECCCCCCEEEECCCCCCEEE
ITAYDYSIYGGLPGEVAVISPDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGM
EEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VATVDIRTGKKSVLDYLLKPFNKAQEALRER
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGQLQYNRGLTEPRLPRSALAVRVTAVMLLCFLGWAWYFQLDEVTTGSGTVEPSGREQV
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHH
VQSLEGGILYHLDVKVGDIVEQGQPLAQLNRTKTESDVQEAMSRLYAALATSARLRAEVS
HHHHCCCEEEEEECCHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NKPLVFPDELNKFPELIESETALYNTRRDGLNKATTGLTQGISLVNRELAMTQPLVKQGA
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASSVEVLRLQRQANELENKLSDVRTQYYVQAREELAKANAEVETQRSVIRGREDSLTRLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEE
FTAPVRGIVQDIDVTTVGGVIAPGGKLMTIVPLDEQLLIEAKISPRDVAFIHPGQKSLVK
CCCHHHHHHHHCCEEEECCEECCCCCEEEEEECCCEEEEEECCCCCCEEEECCCCCCEEE
ITAYDYSIYGGLPGEVAVISPDTVQDEVRRDVYYYRVYIRTFSNHLENKSKQQFPIFPGM
EEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VATVDIRTGKKSVLDYLLKPFNKAQEALRER
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1427098; 10984043 [H]