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The map label for this gene is obgE [H]

Identifier: 209399332

GI number: 209399332

Start: 4174701

End: 4175873

Strand: Reverse

Name: obgE [H]

Synonym: ECH74115_4505

Alternate gene names: 209399332

Gene position: 4175873-4174701 (Counterclockwise)

Preceding gene: 209400681

Following gene: 209400428

Centisome position: 74.94

GC content: 52.86

Gene sequence:

>1173_bases
ATGAAGTTTGTTGATGAAGCATCGATTCTGGTCGTTGCAGGTGATGGCGGTAATGGTTGCGTGAGCTTCCGCCGCGAAAA
GTATATTCCGAAAGGCGGCCCGGATGGCGGCGACGGCGGTGATGGTGGTGACGTATGGATGGAAGCCGACGAGAACCTGA
ACACGCTTATCGATTATCGTTTTGAAAAATCTTTCCGTGCAGAGCGCGGTCAGAATGGCGCAAGCCGCGACTGTACCGGT
AAGCGCGGTAAAGACGTCACAATTAAAGTGCCGGTAGGTACGCGTGTAATCGACCAGGGTACTGGTGAAACCATGGGCGA
TATGACCAAACACGGTCAGCGTCTGCTGGTTGCTAAGGGCGGCTGGCACGGTCTGGGCAATACCCGTTTCAAATCGTCAG
TTAACCGTACACCACGGCAGAAAACTAACGGTACGCCGGGCGATAAGCGTGAGCTGCTGCTGGAGCTGATGCTGCTGGCT
GACGTCGGTATGTTGGGGATGCCAAACGCGGGTAAATCGACCTTTATTCGTGCGGTATCGGCGGCTAAACCGAAAGTGGC
GGATTATCCGTTTACCACTCTGGTGCCAAGTCTGGGTGTGGTACGAATGGACAACGAAAAGAGCTTCGTTGTTGCCGATA
TTCCAGGACTGATTGAAGGCGCTGCGGAAGGCGCAGGTCTGGGCATTCGCTTCCTGAAGCACCTGGAACGTTGCCGCGTC
CTGTTGCACCTCATCGATATCGATCCGATTGACGGCACCGATCCGGTTGAAAACGCGCGTATTATTATCAGCGAGCTGGA
AAAATACAGCCAGGATCTGGCGGCGAAACCGCGTTGGTTAGTCTTCAACAAGATCGATCTGCTGGATAAGGTAGAAGCCG
AAGAGAAAGCGAAAGCGATCGCAGAGGCGCTGGGCTGGGAAGATAAATATTATCTGATCTCTGCGGCGAGTGGACTGGGC
GTGAAAGATCTCTGCTGGGATGTGATGACCTTTATCATTGAAAACCCGGTCGTGCAGGCTGAAGAAGCGAAACAGCCAGA
GAAAGTCGAATTCATGTGGGATGATTATCATCGCCAGCAGCTTGAAGAGATTGCTGAAGAGGATGATGAGGACTGGGATG
ACGACTGGGACGAAGACGACGAAGAAGGCGTTGAGTTCATTTACAAGCGTTAA

Upstream 100 bases:

>100_bases
GATGTATTCCGCCATTGGTCATCGTATTTGGGGCGGATTACGTAAGCATACAACGGTGGTATCGCAACCCCGCGCAGGCG
AATGATTTACGGAGAATAAA

Downstream 100 bases:

>100_bases
TCAGCAAAACCCCGGCCATGTGCCGGGGTTTCTTTTTGACTAATTGTTCTGATAAATATCTTTATACAAACGGCTTTCAA
AACGCACTAACGGAATACGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLG
VKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR

Sequences:

>Translated_390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLG
VKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
>Mature_390_residues
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTG
KRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLA
DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
LLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLG
VKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=344, Percent_Identity=38.6627906976744, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI111955139, Length=293, Percent_Identity=40.2730375426621, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI111955063, Length=129, Percent_Identity=45.7364341085271, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI58761500, Length=129, Percent_Identity=32.5581395348837, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789574, Length=390, Percent_Identity=99.7435897435898, Blast_Score=792, Evalue=0.0,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=31.25, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=322, Percent_Identity=39.1304347826087, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=320, Percent_Identity=31.5625, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=32.2033898305085, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=175, Percent_Identity=36, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129375, Length=285, Percent_Identity=40.7017543859649, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=35.958904109589, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24640873, Length=155, Percent_Identity=31.6129032258064, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640877, Length=155, Percent_Identity=31.6129032258064, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640875, Length=155, Percent_Identity=31.6129032258064, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43256; Mature: 43256

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHH
FEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAI
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
AEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQ
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEHHHHHHHH
LEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHH
FEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVS
CCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAI
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
AEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQ
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEEEHHHHHHHH
LEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA