Click here to switch to the map view.

The map label for this gene is qseC

Identifier: 209398656

GI number: 209398656

Start: 4012995

End: 4014344

Strand: Direct

Name: qseC

Synonym: ECH74115_4335

Alternate gene names: 209398656

Gene position: 4012995-4014344 (Clockwise)

Preceding gene: 209398732

Following gene: 209400260

Centisome position: 72.02

GC content: 52.67

Gene sequence:

>1350_bases
ATGAAATTTACCCAACGTCTTAGTCTGCGTGTCAGGCTGACGCTAATCTTTTTAATTCTGGCCTCGGTGACCTGGCTGCT
TTCCAGCTTTGTCGCCTGGAAACAAACAACGGATAACGTCGATGAATTGTTCGACACCCAACTGATGCTGTTTGCCAAGC
GGTTAAGTACGCTCGATCTCAACGAAATCAACGCGGCGGATCGCATGGCACAGACGCCAAATAAATTAAAACACGGTCAT
GTTGATGACGATGCGCTGACCTTTGCCATCTTTACCCACGACGGCAGAATGGTCCTTAACGATGGCGATAACGGAGAAGA
TATTCCCTATAGCTATCAACGGGAAGGTTTTGCTGACGGGCAACTGGTGGGCGATAAAGATCAATGGCGTTTTGTCTGGA
TGACCTCACCTGATGGCAAATATCGCATCGTTGTTGGTCAGGAATGGGAATACCGTGAAGACATGGCGCTGGCGATTGTT
GCCGGGCAATTGATCCCGTGGTTGGTCGCACTGCCGGTTATGTTAATCATCATGATGGTACTACTGGGTCGTGAACTCGC
GCCGCTGAACAAACTGGCGCTGGCACTACGTATGCGTGACCCTGACTCGGAAAAACCACTAAACGCGACTGGCGTACCCA
GCGAAGTGCGACCACTGGTTGAGTCGCTAAATCAACTGTTCGCCCGCACACATGCGATGATGGTTCGTGAACGACGCTTT
ACCTCCGACGCAGCTCACGAACTTCGTAGCCCGTTAACGGCGCTGAAAGTGCAAACCGAAGTTGCGCAGCTCTCTGACGA
TGATCCGCAGGCGCGGAAAAAAGCACTGCTCCAATTACATTCCGGGATCGATCGCGCTACTCGTCTGGTTGATCAACTGC
TCACGCTATCGCGGCTGGACTCACTGGATAACCTTCAGGACGTCGCGGAGATCCCGCTTGAAGATCTCCTGCAATCGTCG
GTGATGGATATTTACCACACGGCGCAGCAGGCGAAAATTGACGTGCGACTGACACTCAATGTCCAGGGCATCAAACGCAC
CGGACAACCGCTATTGCTAAGTTTGTTGGTGCGAAATTTGCTGGATAACGCCGTGCGTTACAGTCCACAGGGCAGCGTGG
TGGACGTCACGCTGAATGCCGATAATTTCATCGTAAGGGATAACGGCCCCGGTGTGACACCAGAGGCACTGGCGCGAATT
GGCGAACGCTTCTATCGCCCACCCGGACAAACCGCTACCGGCAGTGGACTTGGGCTATCGATTGTCCAGCGAATCGCCAA
GCTGCATGGCATGAATGTTGAGTTTGGGAATGCGGAACAAGGTGGATTTGAGGCGAAGGTAAGCTGGTAA

Upstream 100 bases:

>100_bases
CCAGTAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATT
GGCTACACATTAGGTGAGAA

Downstream 100 bases:

>100_bases
GGGTAAGACTTTTGCTAAATTCGCAAAAGACTTTGCACATTTTGCTAATTTCACCGTACCGCTCTGTGACGTACTATAGT
CGGCAAACGTCTCACCTTGA

Product: sensor protein QseC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH
VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV
AGQLIPWLVALPVMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF
TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS
VMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARI
GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW

Sequences:

>Translated_449_residues
MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH
VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV
AGQLIPWLVALPVMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF
TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS
VMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARI
GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW
>Mature_449_residues
MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNKLKHGH
VDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIV
AGQLIPWLVALPVMLIIMMVLLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF
TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSS
VMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARI
GERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW

Specific function: Member of a two-component regulatory system qseB/qseC. Activates the flagella regulon by activating transcription of flhDC. May activate qseB by phosphorylation

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1789403, Length=449, Percent_Identity=98.2182628062361, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=31.8840579710145, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=31.095406360424, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786600, Length=257, Percent_Identity=30.7392996108949, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=457, Percent_Identity=27.7899343544858, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=27.5747508305648, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790861, Length=477, Percent_Identity=24.7379454926625, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=248, Percent_Identity=26.6129032258064, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=29.1139240506329, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=30.5785123966942, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): QSEC_ECO57 (Q8X524)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- EMBL:   BA000007
- PIR:   D85962
- PIR:   D91117
- PIR:   E91117
- RefSeq:   NP_289601.1
- ProteinModelPortal:   Q8X524
- SMR:   Q8X524
- EnsemblBacteria:   EBESCT00000025665
- EnsemblBacteria:   EBESCT00000058907
- GeneID:   958502
- GenomeReviews:   AE005174_GR
- KEGG:   ece:Z4378
- GeneTree:   EBGT00050000008661
- HOGENOM:   HBG334875
- OMA:   HRNDELE
- ProtClustDB:   PRK10337
- BioCyc:   ECOL83334:ECS3908-MONOMER
- BioCyc:   ECOL83334:ECS3909-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 50259; Mature: 50259

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x114e4f00)-; HASH(0x1127b158)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
NEINAADRMAQTPNKLKHGHVDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADG
HHCCHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCC
QLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIVAGQLIPWLVALPVMLIIMMV
CEECCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF
HHCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD
CHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
LDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLS
HHHHHEECCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHH
IVQRIAKLHGMNVEFGNAEQGGFEAKVSW
HHHHHHHHCCCCCCCCCCCCCCEEEEECH
>Mature Secondary Structure
MKFTQRLSLRVRLTLIFLILASVTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
NEINAADRMAQTPNKLKHGHVDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADG
HHCCHHHHHHCCCHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCC
QLVGDKDQWRFVWMTSPDGKYRIVVGQEWEYREDMALAIVAGQLIPWLVALPVMLIIMMV
CEECCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGRELAPLNKLALALRMRDPDSEKPLNATGVPSEVRPLVESLNQLFARTHAMMVRERRF
HHCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLD
CHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
SLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNVQGIKRTGQPLLLSLLVRNL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCCCCCHHHHHHHHHHHH
LDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLS
HHHHHEECCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHH
IVQRIAKLHGMNVEFGNAEQGGFEAKVSW
HHHHHHHHCCCCCCCCCCCCCCEEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 11929534