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The map label for this gene is frwC

Identifier: 209398507

GI number: 209398507

Start: 5052525

End: 5053604

Strand: Direct

Name: frwC

Synonym: ECH74115_5409

Alternate gene names: 209398507

Gene position: 5052525-5053604 (Clockwise)

Preceding gene: 209396472

Following gene: 209400450

Centisome position: 90.68

GC content: 53.98

Gene sequence:

>1080_bases
ATGAATGAGTTGGTGCAGATCCTGAAAAATACCCGTCAGCATTTAATGACGGGCGTTTCACACATGATTCCCTTCGTGGT
ATCGGGCGGTATTTTGCTGGCGGTTTCCGTCATGTTGTATGGCAAAGGCGCAGTGCCGGATGCCGTAGCCGATCCGAATC
TGAAAAAACTGTTTGATATCGGCGTTGCAGGTTTGACGCTGATGGTGCCTTTCCTCGCCGCTTACATCGGTTACTCCATT
GCAGAGCGTTCTGCGCTGGCTCCGTGCGCTATCGGTGCCTGGGTTGGTAACAGCTTTGGTGCGGGCTTCTTTGGTGCACT
GATCGCCGGGATTATCGGCGGCATCGTGGTGCATTACCTGAAGAAAATTCCGGTGCATAAAGTTCTGCGCTCGGTGATGC
CCATCTTCATCATTCCGATCGTCGGCACACTGATTACCGCAGGCATCATGATGTGGGGTCTGGGCGAGCCTGTAGGGGCG
TTGACCAACAGCCTGACTCAGTGGCTTCAGGGGATGCAGCAGGGCAGCATTGTTATGCTGGCGGTGATCATGGGTCTGAT
GCTGGCGTTCGATATGGGCGGTCCGGTTAACAAAGTGGCCTATGCCTTCATGCTGATTTGCGTTGCTCAGGGTGTTTATA
CCGTGGTGGCCATTGCTGCCGTGGGTATTTGTATCCCGCCGCTGGGGATGGGGCTGGCGACGCTGATTGGTCGTAAAAAT
TTCTCCGCAGAAGAGCGCGAAACCGGTAAAGCGGCGCTGGTGATGGGGTGCGTTGGGGTTACTGAAGGGGCGATTCCTTT
CGCCGCAGCCGATCCGTTACGTGTAATTCCTTCCATCATGGTTGGTTCAGTTTGTGGTGCAGTAACTGCGGCGCTGGTCG
GTGCGCAGTGCTATGCAGGCTGGGGTGGTCTGATTGTGCTGCCGGTGGTTGAAGGTAAGTTGGGTTATATCGCAGCAGTG
GCTGTCGGGGCGGTTGTGACGGCAGTCTGCGTGAACGTGCTGAAAAGTCTGGCGCGTAAAAATGGATCTTCTACTGATGA
AAAAGAAGACGACCTGGATTTGGATTTTGAAATTAATTAA

Upstream 100 bases:

>100_bases
TAAATGGCCTTTTTATCCACTGTTTGCTCCGCCTGCGATTGCCTATTGTTTCCTCCATCAAAAATATGGACATGGGCTTT
CGCAAGCCCGGGAGCAGCTT

Downstream 100 bases:

>100_bases
TTGAGGAACGAGCCATGACGAAAATTATTGCAGTAACCGCGTGTCCATCTGGTGTTGCCCATACTTATATGGCTGCAGAG
GCGCTGGAAAGTGCCGCGAA

Product: putative fructose-like permease EIIC subunit 2

Products: NA

Alternate protein names: PTS system fructose-like EIIC component 2

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDIGVAGLTLMVPFLAAYIGYSI
AERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYLKKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGA
LTNSLTQWLQGMQQGSIVMLAVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKN
FSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAGWGGLIVLPVVEGKLGYIAAV
AVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN

Sequences:

>Translated_359_residues
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDIGVAGLTLMVPFLAAYIGYSI
AERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYLKKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGA
LTNSLTQWLQGMQQGSIVMLAVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKN
FSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAGWGGLIVLPVVEGKLGYIAAV
AVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN
>Mature_359_residues
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDIGVAGLTLMVPFLAAYIGYSI
AERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYLKKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGA
LTNSLTQWLQGMQQGSIVMLAVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKN
FSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAGWGGLIVLPVVEGKLGYIAAV
AVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain

Homologues:

Organism=Escherichia coli, GI1790386, Length=359, Percent_Identity=100, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI1788492, Length=332, Percent_Identity=40.6626506024096, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786951, Length=349, Percent_Identity=36.3896848137536, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082348, Length=291, Percent_Identity=35.7388316151203, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788729, Length=376, Percent_Identity=28.4574468085106, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTFC2_ECOLI (P32672)

Other databases:

- EMBL:   U00006
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H65201
- RefSeq:   AP_003861.1
- RefSeq:   NP_418384.1
- ProteinModelPortal:   P32672
- STRING:   P32672
- EnsemblBacteria:   EBESCT00000004703
- EnsemblBacteria:   EBESCT00000017674
- GeneID:   948448
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3921
- KEGG:   eco:b3949
- EchoBASE:   EB1852
- EcoGene:   EG11908
- eggNOG:   COG1299
- GeneTree:   EBGT00070000031702
- HOGENOM:   HBG704192
- OMA:   IQNRITD
- ProtClustDB:   PRK10478
- BioCyc:   EcoCyc:FRWC-MONOMER
- Genevestigator:   P32672
- InterPro:   IPR013014
- InterPro:   IPR006327
- TIGRFAMs:   TIGR01427

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 37087; Mature: 37087

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x129d5d54)-; HASH(0x135216f8)-; HASH(0x13365bc4)-; HASH(0x1313f3c4)-; HASH(0x1354b810)-; HASH(0x133da930)-; HASH(0x13430754)-; HASH(0x11ebbbbc)-; HASH(0x13531b9c)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GVAGLTLMVPFLAAYIGYSIAERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGALTNSLTQWLQGMQQGSIVML
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
AVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
FSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAG
CCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGGLIVLPVVEGKLGYIAAVAVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECH
>Mature Secondary Structure
MNELVQILKNTRQHLMTGVSHMIPFVVSGGILLAVSVMLYGKGAVPDAVADPNLKKLFDI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GVAGLTLMVPFLAAYIGYSIAERSALAPCAIGAWVGNSFGAGFFGALIAGIIGGIVVHYL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KKIPVHKVLRSVMPIFIIPIVGTLITAGIMMWGLGEPVGALTNSLTQWLQGMQQGSIVML
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
AVIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTVVAIAAVGICIPPLGMGLATLIGRKN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
FSAEERETGKAALVMGCVGVTEGAIPFAAADPLRVIPSIMVGSVCGAVTAALVGAQCYAG
CCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGGLIVLPVVEGKLGYIAAVAVGAVVTAVCVNVLKSLARKNGSSTDEKEDDLDLDFEIN
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 7773398