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The map label for this gene is dxs [H]

Identifier: 209398295

GI number: 209398295

Start: 507954

End: 509816

Strand: Reverse

Name: dxs [H]

Synonym: ECH74115_0503

Alternate gene names: 209398295

Gene position: 509816-507954 (Counterclockwise)

Preceding gene: 209397720

Following gene: 209399102

Centisome position: 9.15

GC content: 53.68

Gene sequence:

>1863_bases
ATGAGTTTTGATATTGCCAAATACCCGACCCTGGCACTGGTCGACTCCACCCAGGAGCTACGACTGTTGCCAAAAGAGAG
TTTACCGAAACTCTGCGACGAACTGCGCCGCTATTTACTCGACAGCGTGAGCCGTTCCAGCGGGCACTTCGCCTCCGGGC
TGGGCACGGTCGAACTGACCGTGGCGCTGCACTATGTCTATAACACCCCGTTTGACCAATTGATTTGGGATGTGGGGCAT
CAGGCTTATCCGCATAAAATTTTGACCGGACGCCGCGACAAAATCGGCACCATCCGTCAGAAAGGCGGTCTACACCCGTT
CCCGTGGCGCGGCGAAAGCGAATATGACGTATTAAGCGTCGGGCATTCATCAACCTCCATCAGTGCCGGAATTGGTATTG
CGGTTGCTGCCGAGAAAGAAGGCAAAAATCGCCGCACCGTCTGTGTGATTGGCGACGGCGCGATTACCGCAGGCATGGCG
TTTGAAGCGATGAATCACGCGGGCGATATTCGTCCTGATATGCTGGTGGTCCTCAACGACAATGAAATGTCGATTTCCGA
AAATGTTGGCGCGCTTAACAACCATCTGGCGCAGCTGCTTTCCGGTAAGCTTTACTCTTCACTGCGCGAAGGCGGGAAAA
AAGTTTTCTCTGGCGTTCCGCCAATTAAAGAGCTGCTCAAACGTACCGAAGAACATATTAAAGGCATGGTGGTGCCTGGC
ACGTTGTTTGAAGAGCTGGGCTTTAACTACATCGGCCCGGTTGACGGTCACGATGTGCTGGGGCTTATCACCACGCTGAA
GAACATGCGCGACCTGAAAGGCCCGCAGTTCCTGCATATCATGACCAAAAAAGGTCGTGGTTATGAACCGGCAGAAAAAG
ACCCAATCACCTTCCACGCCGTGCCTAAATTTGATCCCTCCAGCGGTTGTTTGCCGAAAAGTAGCGGTGGTTTACCAAGC
TATTCAAAAATCTTTGGCGACTGGTTGTGCGAAACGGCAGCGAAAGATAACAAACTGATGGCGATTACTCCGGCGATGCG
TGAAGGTTCCGGCATGGTCGAGTTTTCACGTAAATTCCCGGATCGCTATTTTGATGTAGCGATTGCCGAGCAACACGCGG
TGACCTTTGCCGCCGGTCTGGCGATTGGTGGCTACAAACCGATCGTGGCAATTTACTCCACCTTCCTGCAACGCGCCTAT
GATCAGGTGCTGCATGACGTGGCAATTCAAAAACTCCCGGTCCTGTTCGCCATCGACCGCGCGGGCATTGTTGGTGCTGA
CGGTCAAACCCACCAGGGCGCTTTTGATCTCTCTTACCTGCGCTGCATACCGGAAATGGTCATTATGACCCCGAGCGATG
AAAACGAATGTCGCCAGATGCTCTATACCGGCTATCACTATAACGATGGCCCGTCAGCGGTGCGCTACCCGCGTGGCAAC
GCGGTCGGCGTGGAACTGACGCCGCTGGAAAAACTACCAATTGGCAAAGGCATTGTGAAGCGTCGTGGCGAGAAACTGGC
GATCCTTAACTTTGGTACGCTGATGCCAGAAGCGGCGAAAGTCGCCGAATCGCTGAACGCCACGCTGGTCGATATGCGTT
TTGTGAAACCGCTTGATGAAACGTTAATTCTGGAAATGGCCGCCAGTCATGAAGCACTGGTTACCGTAGAAGAAAACGCC
ATTATGGGCGGTGCAGGCAGCGGAGTGAACGAAGTGCTGATGGCCCATCGTAAACCAGTACCCGTGCTGAACATTGGCCT
GCCGGACTTCTTTATTCCGCAAGGAACTCAGGAAGAAATGCGCGCCGAACTCGGCCTCGATGCCGCCGGTATGGAAGCCA
AAATCAAGGCCTGGCTGGCATAA

Upstream 100 bases:

>100_bases
ACAACTGGCTGAACAGTCGATCGATACTTCGGCACTGGAAGCGCTAGCGGACTACATCATCCAGCGTAATAAATAAACAA
TAAGTGTTAATAGGCCCCTG

Downstream 100 bases:

>100_bases
TCCCTACTCCACTCCTGCTATGCTTAAGAAATTATTCATGGCAGGAGTGGCAGCATGCAATACAACCCCTTAGGAAAAAC
CGACCTTCGCGTTTCCCGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDETLILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDETLILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAF
EAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSY
SKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYD
QVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNA
VGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDETLILEMAASHEALVTVEENAI
MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=496, Percent_Identity=22.9838709677419, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4507521, Length=496, Percent_Identity=22.9838709677419, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI225637463, Length=546, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI225637461, Length=546, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.943661971831, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637459, Length=546, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=99.6774193548387, Blast_Score=1274, Evalue=0.0,
Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=24.3856332703214, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551847, Length=632, Percent_Identity=24.0506329113924, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45550715, Length=632, Percent_Identity=24.0506329113924, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666278, Length=487, Percent_Identity=24.0246406570842, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67634; Mature: 67503

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEHHHHCCCHH
TLILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEHHHHCCCHH
TLILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA