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The map label for this gene is phoR [H]

Identifier: 209398260

GI number: 209398260

Start: 483455

End: 484750

Strand: Direct

Name: phoR [H]

Synonym: ECH74115_0476

Alternate gene names: 209398260

Gene position: 483455-484750 (Clockwise)

Preceding gene: 209398675

Following gene: 209397609

Centisome position: 8.68

GC content: 53.24

Gene sequence:

>1296_bases
GTGCTGGAACGGCTGTCGTGGAAAAGGCTGGTGCTGGAGCTGCTACTTTGCTGCCTCCCGGCTTTCATCCTGGGTGCATT
TTTTGGTTACCTGCCCTGGTTTTTGCTGGCATCGGTAACAGGACTGCTTATCTGGCATTTCTGGAATTTATTGCGCCTTT
CATGGTGGCTGTGGGTGGATCGCAGTATGACCCCGCCACCGGGGCGTGGTAGCTGGGAACCGCTACTATACGGCTTACAC
CAGATGCAGCTGCGAAATAAAAAACGCCGCCGTGAACTGGGCAATCTGATTAAACGCTTTCGTAGCGGCGCGGAGTCGCT
GCCCGACGCGGTGGTGCTGACCACGGAAGAGGGCGGTATTTTCTGGTGTAACGGTCTGGCGCAACAGATTCTTGGTTTGC
GCTGGCCGGAAGATAACGGGCAGAACATCCTTAACCTGCTGCGTTACCCGGAGTTTACGCAATATTTGAAAACGCGTGAT
TTTTCTCGCCCGCTCAATCTGGTGCTCAACACCGGGCGGCATCTGGAAATTCGCGTCATGCCTTATACCCACAAACAGTT
GCTGATGGTGGCGCGTGATGTCACGCAAATGCATCAACTGGAAGGGGCGCGGCGTAACTTTTTTGCCAACGTGAGCCATG
AGTTACGTACGCCATTGACCGTGTTACAGGGTTACCTGGAGATGATGGATGAGCAGCCGCTGGAAGGCGCGGTACGCGAA
AAAGCGTTGCACACCATGCGCGAGCAGACCCAGCGGATGGAAGGGCTGGTGAAGCAGTTGCTAACGCTGTCGAAAATTGA
AGCCGCACCGACGCAATTGCTCAATGAAAAGGTTGATGTGCCGATGATGCTGCGCGTTGTTGAGCGCGAGGCTCAGACTC
TGAGTCAGAAAAAACAGACATTTACCTTCGAGATAGATAACGGCCTCAAGGTGTCTGGCAACGAAGATCAGCTACGCAGT
GTGATTTCGAACCTGGTCTATAACGCCGTGAATCATACGCCGGAAGGCACGCATATCACCGTACGCTGGCAGCGAGTGCC
GCACGGTGCCGAATTTAGCGTTGAAGATAACGGACCGGGCATTGCACCGGAGCATATTCCGCGCCTGACCGAGCGTTTTT
ATCGCGTTGATAAAGCGCGTTCCCGGCAAACCGGCGGTAGCGGATTAGGGTTAGCGATCGTGAAACATGCGGTGAATCAT
CACGAAAGTCGCCTGAATATTGAGAGTACAGTAGGAAAAGGAACACGTTTCAGTTTTGTTATCCCGGAACGTTTAATTGT
CAAAAACAGCGATTAA

Upstream 100 bases:

>100_bases
GACCGTGCGCGGTACAGGATATCGTTTTTCAACCCGCTTTTAACGCCTTGCTCATCGGACGCAGAGCAGGGCTTATGATT
TCTTAACTGGAGTATCTTAC

Downstream 100 bases:

>100_bases
TCCGCCTTTGTCATCTTTTATTGCCATAAGCCAGCCGATGCTGGCTTATTTTCTTTGCAGTCAAAATACGGGCGTTAGAT
TTTACAACGGTTGGTGATTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRD
FSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMDEQPLEGAVRE
KALHTMREQTQRMEGLVKQLLTLSKIEAAPTQLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRS
VISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HESRLNIESTVGKGTRFSFVIPERLIVKNSD

Sequences:

>Translated_431_residues
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRD
FSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMDEQPLEGAVRE
KALHTMREQTQRMEGLVKQLLTLSKIEAAPTQLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRS
VISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HESRLNIESTVGKGTRFSFVIPERLIVKNSD
>Mature_431_residues
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRD
FSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMDEQPLEGAVRE
KALHTMREQTQRMEGLVKQLLTLSKIEAAPTQLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRS
VISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HESRLNIESTVGKGTRFSFVIPERLIVKNSD

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=431, Percent_Identity=99.0719257540603, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=33.4600760456274, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=27.6679841897233, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=29.8701298701299, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=31.8777292576419, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=29.2576419213974, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789403, Length=257, Percent_Identity=30.3501945525292, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=266, Percent_Identity=29.3233082706767, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.0089686098655, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788549, Length=347, Percent_Identity=23.6311239193084, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=30.0429184549356, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=199, Percent_Identity=31.1557788944724, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=201, Percent_Identity=29.8507462686567, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=26.8199233716475, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=351, Percent_Identity=26.2108262108262, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=26.4069264069264, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=336, Percent_Identity=24.4047619047619, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790567, Length=352, Percent_Identity=24.4318181818182, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787374, Length=268, Percent_Identity=22.3880597014925, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49678; Mature: 49678

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHHCCCCEEEEEEE
PYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMDEQPLEGAVRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCCCHHHHHH
KALHTMREQTQRMEGLVKQLLTLSKIEAAPTQLLNEKVDVPMMLRVVEREAQTLSQKKQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHE
FTFEIDNGLKVSGNEDQLRSVISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPG
EEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCCCCC
IAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEE
IPERLIVKNSD
CCCHHEEECCC
>Mature Secondary Structure
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHHCCCCEEEEEEE
PYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMDEQPLEGAVRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCCCHHHHHH
KALHTMREQTQRMEGLVKQLLTLSKIEAAPTQLLNEKVDVPMMLRVVEREAQTLSQKKQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHE
FTFEIDNGLKVSGNEDQLRSVISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPG
EEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEECCCCCC
IAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEE
IPERLIVKNSD
CCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]