Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 209397791

GI number: 209397791

Start: 4859247

End: 4860731

Strand: Reverse

Name: gppA [H]

Synonym: ECH74115_5212

Alternate gene names: 209397791

Gene position: 4860731-4859247 (Counterclockwise)

Preceding gene: 209397506

Following gene: 209398694

Centisome position: 87.23

GC content: 53.67

Gene sequence:

>1485_bases
ATGGGTTCCACCTCATCGCTGTATGCAGCCATTGATCTCGGTTCGAATAGTTTTCATATGCTGGTTGTGCGCGAGGTGGC
TGGAAGCATCCAGACGCTGACGCGAATAAAACGCAAAGTGCGTCTGGCTGCTGGCCTGAATAGCGAAAATGCCCTCTCCA
ATGAAGCAATGGAGCGCGGTTGGCAATGTTTGCGCCTGTTTGCTGAACGTCTGCAAGATATTCCTCCCTCGCAAATTCGC
GTTGTCGCTACGGCGACGTTACGCCTTGCCGTCAATGCGGGTGATTTTATTGCCAAAGCGCAGGAAATCCTCGGTTGTCC
GGTACAGGTGATCAGCGGTGAAGAGGAAGCACGTCTGATTTATCAGGGTGTTGCTCACACCACTGGCGGTGCCGATCAGC
GCCTGGTAGTGGATATCGGCGGTGCCAGTACTGAACTGGTAACCGGCACGGGTGCACAAACCACCTCGTTGTTCAGCCTG
TCGATGGGCTGCGTCACCTGGCTGGAACGCTATTTTGCCGATCGTAATCTGGGGCAGGAAAATTTTGATGCTGCAGAAAA
AGCGGCACGCGAAGTGTTACGTCCGGTTGCCGATGAATTACGGTATCACGGCTGGAAAGTGTGCGTTGGTGCTTCCGGCA
CCGTGCAGGCGTTACAGGAAATCATGATGGCACAGGGGATGGATGAACGCATTACCCTGGAAAAGTTGCAGCAATTGAAA
CAGCGAGCCATTCATTGCGGTCGGCTGGAGGAACTGGAGATTGACGGGCTGACGCTGGAACGTGCGTTAGTGTTCCCGAG
TGGTCTGGCGATCCTGATCGCCATTTTTACCGAACTGAATATTCAGTGTATGACCCTGGCGGGCGGTGCGCTGCGTGAAG
GCCTGGTCTACGGCATGTTGCATCTGGCCGTCGAGCAGGATATTCGCAGCCGTACGCTGCGTAATATTCAACGCCGCTTT
ATGATCGATATTGATCAGGCACAGCGCGTAGCCAAAGTTGCGGCTAACTTCTTCGATCAGGTGGAAAACGAATGGCATCT
TGAAGCAATAAGCCGCGATTTGCTCATCAGCGCCTGTCAGCTTCATGAAATCGGCCTGAGCGTTGACTTCAAACAAGCGC
CGCAACACGCTGCTTATCTGGTGCGTAATCTGGATCTTCCCGGTTTTACCCCCGCACAGAAAAAATTGCTGGCGACGCTA
CTGCTCAACCAGACTAATCCGGTCGATCTCTCATCGCTGCATCAGCAAAATGCCGTACCGCCGCGCGTCGCAGAACAACT
CTGCCGTTTACTACGCCTGGCCATCATTTTTGCCAGCCGTCGCCGTGACGATCTCGTGCCAGAGATGACATTACAGGCTA
ACCATGAACTGTTGACCTTGACGCTTCCGCAAGGTTGGCTAACCCAACATCCGCTGGGTAAAGAGATTATTGCTCAGGAA
AGCCAGTGGCAGAGCTATGTCCACTGGCCGCTGGAAGTGCATTAA

Upstream 100 bases:

>100_bases
ATCAAGATGGCAAGAGAATGAATCCCGATGAGCTTACTGTAGTAAGTGATTCAGGTGAAAGAATGCAGCCAACACAGAGA
CAGATTGAAGGATGAAGAGT

Downstream 100 bases:

>100_bases
TGAGTAAGTGCCGGATGCGATGCTGACGCATCTTTTCCGGCCTTGATTATTTCCCTCGTTTTGCCGCCATCATCGCTTTC
AGATTCGCCAGATGGCTTTG

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
SQWQSYVHWPLEVH

Sequences:

>Translated_494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
SQWQSYVHWPLEVH
>Mature_493_residues
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRV
VATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQ
RAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFM
IDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLL
LNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQES
QWQSYVHWPLEVH

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=494, Percent_Identity=100, Blast_Score=1010, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=495, Percent_Identity=38.7878787878788, Blast_Score=329, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54872; Mature: 54741

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERG
CCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEHHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHHCC
SQWQSYVHWPLEVH
HHHHHHCCCCEEEC
>Mature Secondary Structure 
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERG
CCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEHHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHHCC
SQWQSYVHWPLEVH
HHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA