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The map label for this gene is dtpB [H]

Identifier: 209397711

GI number: 209397711

Start: 4478251

End: 4479720

Strand: Direct

Name: dtpB [H]

Synonym: ECH74115_4843

Alternate gene names: 209397711

Gene position: 4478251-4479720 (Clockwise)

Preceding gene: 209398493

Following gene: 209396007

Centisome position: 80.37

GC content: 51.36

Gene sequence:

>1470_bases
ATGAATACAACAACACCCATGGGGATGCTGCAGCAACCTCGCCCATTTTTCATGATCTTTTTTGTCGAGTTATGGGAGCG
ATTCGGCTACTACGGCGTGCAGGGCGTACTGGCGGTTTTCTTCGTTAAACAGCTTGGATTCTCGCAAGAGCAGGCTTTTG
TCACTTTTGGTGCTTTTGCTGCACTGGTCTATGGCCTCATTTCCATTGGCGGCTATGTCGGCGACCACCTGCTGGGGACC
AAACGCACCATCGTTCTTGGAGCACTTGTGCTGGCGATTGGCTACTTCATGACCGGCATGTCGCTACTTAAGCCTGACCT
GATTTTCATCGCCCTGGGGACTATCGCTGTCGGTAACGGCCTGTTTAAAGCTAACCCAGCCAGCTTGCTTTCGAAGTGCT
ATCCGCCGAAAGATCCGCGCCTTGATGGCACATTCACCCTGTTCTATATGTCGATCAATATCGGCTCGTTGATAGCGTTA
TCGCTGGCCCCTGTGATCGCTGATAAATTCGGCTATTCAGTCACCTACAACCTGTGCGGTGCGGGGTTAATTATCGCATT
ACTGGTTTACATCGCCTGTCGTGGAATGGTGAAAGACATTGGTTCTGAGCCCGACTTCCGGCCAATGAGCTTCAGCAAAC
TGTTGTACGTATTACTTGGCAGCGTGGTGATGATCTTCGTCTGCGCCTGGCTGATGCACAACGTAGAAGTCGCCAATCTG
GTGCTGATTGTTCTCTCCATCGTCGTCACCATCATCTTCTTTCGTCAGGCATTCAAGCTGGATAAAACCGGGCGCAATAA
AATGTTTGTCGCCTTTGTCCTGATGCTCGAAGCGGTGGTGTTTTACATTCTCTACGCCCAGATGCCAACATCGCTGAACT
TCTTTGCCATCAACAACGTGCATCATGAAATTCTCGGTTTTTCCATCAACCCGGTCAGCTTCCAGGCGCTTAACCCGTTC
TGGGTGGTACTCGCCAGCCCAATACTGGCAGGCATTTACACGCATCTGGGTAACAAAGGCAAAGACCTCTCGATGCCGAT
GAAATTTACTCTCGGCATGTTTATGTGCTCACTGGGCTTTTTGACGGCGGCAGCTGCGGGAATGTGGTTTGCGGATGCAC
AAGGGCTGACATCGCCATGGTTTATCGTGCTGGTGTACTTATTCCAGAGCTTAGGTGAACTGTTTATTAGCGCCCTTGGC
CTGGCGATGATTGCTGCTCTGGTGCCGCAGCATTTGATGGGCTTTATTCTCGGGATGTGGTTCCTGACACAGGCTGCCGC
GTTCTTGCTGGGCGGCTATGTGGCAACATTTACCGCAGTACCAGACAACATTACCGATCCGCTTGAGACGTTGCCTGTCT
ATACCAACGTGTTTGGTAAGATTGGTCTGGTCACGCTGGGCGTTGCAGTAGTGATGCTGTTGATGGTGCCGTGGCTGAAA
CGCATGATTGCGACGCCGGAAAGCCATTAA

Upstream 100 bases:

>100_bases
ACCGCATCAATATTAAGAATCTCTGACAGATGTAAACTTTTTCGCGCGTTATCCCTTACGCGTTCATACTTTTCAGGATG
GTATTGGAAGGTTAATAAAT

Downstream 100 bases:

>100_bases
TTATTCTTGCAGAAAGCAGGGTAGCGTTATCGCTACCCTGCTTTACTTTTACACTGGCGTACCTGCATAGATATCAAAGC
GATGCCCTTTAGTCACAACC

Product: inner membrane transporter YhiP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGALVLAIGYFMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGTFTLFYMSINIGSLIAL
SLAPVIADKFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANL
VLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVLASPILAGIYTHLGNKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALG
LAMIAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLK
RMIATPESH

Sequences:

>Translated_489_residues
MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGALVLAIGYFMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGTFTLFYMSINIGSLIAL
SLAPVIADKFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANL
VLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVLASPILAGIYTHLGNKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALG
LAMIAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLK
RMIATPESH
>Mature_489_residues
MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGALVLAIGYFMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGTFTLFYMSINIGSLIAL
SLAPVIADKFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANL
VLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVLASPILAGIYTHLGNKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALG
LAMIAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLK
RMIATPESH

Specific function: Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=384, Percent_Identity=22.65625, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI226371746, Length=193, Percent_Identity=29.5336787564767, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789911, Length=489, Percent_Identity=99.5910020449898, Blast_Score=977, Evalue=0.0,
Organism=Escherichia coli, GI1787922, Length=481, Percent_Identity=52.1829521829522, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1786927, Length=481, Percent_Identity=27.027027027027, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790572, Length=486, Percent_Identity=27.1604938271605, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17541704, Length=376, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569141, Length=385, Percent_Identity=24.4155844155844, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI28571098, Length=212, Percent_Identity=26.8867924528302, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571102, Length=212, Percent_Identity=26.8867924528302, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571100, Length=212, Percent_Identity=26.8867924528302, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24639583, Length=329, Percent_Identity=24.6200607902736, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639585, Length=329, Percent_Identity=24.6200607902736, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639581, Length=329, Percent_Identity=24.6200607902736, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53578; Mature: 53578

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFA
CCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALVYGLISIGGYVGDHLLGTKRTIVLGALVLAIGYFMTGMSLLKPDLIFIALGTIAVGNG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
LFKANPASLLSKCYPPKDPRLDGTFTLFYMSINIGSLIALSLAPVIADKFGYSVTYNLCG
CCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHHH
AGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCH
HHEILGFSINPVSFQALNPFWVVLASPILAGIYTHLGNKGKDLSMPMKFTLGMFMCSLGF
HHHHHCCCCCCCEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALGLAMIAALVPQHLMGFILGMW
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMIATPESH
HHHCCCCCC
>Mature Secondary Structure
MNTTTPMGMLQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFA
CCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALVYGLISIGGYVGDHLLGTKRTIVLGALVLAIGYFMTGMSLLKPDLIFIALGTIAVGNG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
LFKANPASLLSKCYPPKDPRLDGTFTLFYMSINIGSLIALSLAPVIADKFGYSVTYNLCG
CCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHHH
AGLIIALLVYIACRGMVKDIGSEPDFRPMSFSKLLYVLLGSVVMIFVCAWLMHNVEVANL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VLIVLSIVVTIIFFRQAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCH
HHEILGFSINPVSFQALNPFWVVLASPILAGIYTHLGNKGKDLSMPMKFTLGMFMCSLGF
HHHHHCCCCCCCEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LTAAAAGMWFADAQGLTSPWFIVLVYLFQSLGELFISALGLAMIAALVPQHLMGFILGMW
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMIATPESH
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503 [H]