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The map label for this gene is tppB [H]

Identifier: 209397691

GI number: 209397691

Start: 2218791

End: 2220293

Strand: Direct

Name: tppB [H]

Synonym: ECH74115_2346

Alternate gene names: 209397691

Gene position: 2218791-2220293 (Clockwise)

Preceding gene: 209396011

Following gene: 209397168

Centisome position: 39.82

GC content: 51.63

Gene sequence:

>1503_bases
GTGTCCACTGCAAACCAAAAACCAACTGAAAGCGTCAGTTTGAACGCTTTCAAACAACCGAAGGCGTTCTATCTCATCTT
CTCGATTGAGTTATGGGAACGTTTTGGTTATTACGGCCTACAAGGAATTATGGCTGTTTACCTGGTTAAACAACTGGGTA
TGTCTGAAGCGGATTCAATCACCCTTTTCTCTTCCTTTAGTGCCCTGGTTTATGGTCTGGTCGCTATCGGCGGCTGGTTA
GGTGACAAGGTACTGGGTACTAAACGCGTAATTATGCTCGGCGCTATTGTGCTGGCGATTGGTTATGCTCTGGTTGCCTG
GTCTGGTCACGACGCCGGTATCGTTTATATGGGTATGGCGGCTATTGCGGTCGGTAACGGCCTGTTTAAAGCTAACCCGT
CTTCTCTGCTTTCTACATGCTATGAGAAAAACGACCCGCGTCTGGACGGTGCATTCACCATGTACTACATGTCCGTCAAC
ATCGGCTCTTTCTTCTCTATGATCGCCACCCCGTGGCTGGCCGCGAAATACGGCTGGAGTGTTGCGTTTGCGTTGAGCGT
TGTAGGCCTGCTGATCACTATCGTTAACTTCGCCTTCTGCCAACGCTGGGTTAAACAGAACGGTTCAAAACCAGACTTCG
AGCCTATCAACTACCGTAACCTGCTGCTGACCATTATTGGTGTTGTGGCACTGATCGCTATCGCCACCTGGCTGCTGCAC
AATCAGGAAGTTGCGCGTATGGCGCTGGGCGTTGTTGCCTTCGGTATCGTGGTTATCTTCGGTAAAGAAGCCTTCGCGAT
GAAAGGTGCTGCGCGTCGTAAAATGATCGTTGCCTTCATCCTGATGCTCGAAGCCATTATCTTCTTCGTGCTGTACAGCC
AGATGCCAACGTCACTGAACTTCTTTGCGATTCGTAACGTTGAACATACCATTCTGGGCCTGGCCGTAGAACCTGAGCAG
TATCAGGCACTGAACCCGTTCTGGATCATCATTGGTAGCCCGATTCTGGCCGCTATCTATAACAAGATGGGCGATACCCT
GCCGATGCCAACCAAGTTTGCAATCGGTATGGTGATGTGTTCTGGTGCGTTCCTGATTCTGCCGCTGGGTGCGAAATTCG
CGTCTGACGCAGGTATCGTGTCTGTAAGCTGGCTGGTCGCGAGCTATGGCCTGCAGAGTATCGGGGAACTGATGATCTCT
GGTCTGGGTCTGGCAATGGTTGCACAACTCGTTCCGCAGCGTCTGATGGGCTTCATTATGGGTAGCTGGTTCCTGACCAC
TGCCGGTGCAAACCTGATTGGTGGTTATGTTGCGGGTATGATGGCTGTGCCGGATAACGTTACCGATCCGCTGATGTCAC
TGGAAGTCTATGGTCGCGTATTCTTGCAGATTGGTGTCGCTACTGCCGTTATTGCAGTACTGATGCTGCTGACCGCGCCG
AAACTGCACCGCATGACGCAGGATGACGCTGCAGACAAAGCGGCGAAAGCAGCCGTAGCGTAA

Upstream 100 bases:

>100_bases
CTGCCGTTTCCCCTCCCACTATAACAATTGCGCGTATGTTTTTTAGACATAACGCGAGAAAGCACCCCCGTTAATATGGG
ATGTAAAAAAAGAGGTAAAA

Downstream 100 bases:

>100_bases
AATTCAGGGAAACTCTTTTACAAGCCGCTAACTTTTCGTTAGCGGCTTTTTTTTTGTTCAGCAACGCACTACCATACTTT
AAACCACAGACAAAAGGAGT

Product: putative tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVN
IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQNGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH
NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGLAVEPEQ
YQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP
KLHRMTQDDAADKAAKAAVA

Sequences:

>Translated_500_residues
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVN
IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQNGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH
NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGLAVEPEQ
YQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP
KLHRMTQDDAADKAAKAAVA
>Mature_499_residues
STANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG
DKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNI
GSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQNGSKPDFEPINYRNLLLTIIGVVALIAIATWLLHN
QEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHTILGLAVEPEQY
QALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISG
LGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAPK
LHRMTQDDAADKAAKAAVA

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=390, Percent_Identity=24.3589743589744, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226371746, Length=347, Percent_Identity=24.207492795389, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787922, Length=500, Percent_Identity=99.6, Blast_Score=1001, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=481, Percent_Identity=52.1829521829522, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1790572, Length=469, Percent_Identity=28.997867803838, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786927, Length=438, Percent_Identity=28.5388127853881, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17541704, Length=375, Percent_Identity=23.4666666666667, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71987453, Length=371, Percent_Identity=22.6415094339623, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569141, Length=341, Percent_Identity=24.3401759530792, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639585, Length=336, Percent_Identity=25.5952380952381, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24639583, Length=327, Percent_Identity=25.3822629969419, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639581, Length=332, Percent_Identity=25.3012048192771, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28571098, Length=367, Percent_Identity=24.2506811989101, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571102, Length=367, Percent_Identity=24.2506811989101, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571100, Length=367, Percent_Identity=24.2506811989101, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53957; Mature: 53826

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2 ; PS50850 MFS ; PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH
AIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWS
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHCHH
VAFALSVVGLLITIVNFAFCQRWVKQNGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIRNVEHTILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMC
EEEECCCCEEHEEEEECCHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
SGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
CCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP
HHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KLHRMTQDDAADKAAKAAVA
HHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
STANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC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HHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]