| Definition | Escherichia coli O157:H7 str. EC4115, complete genome. |
|---|---|
| Accession | NC_011353 |
| Length | 5,572,075 |
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The map label for this gene is entA [H]
Identifier: 209397468
GI number: 209397468
Start: 713296
End: 714042
Strand: Direct
Name: entA [H]
Synonym: ECH74115_0681
Alternate gene names: 209397468
Gene position: 713296-714042 (Clockwise)
Preceding gene: 209396636
Following gene: 209397763
Centisome position: 12.8
GC content: 57.7
Gene sequence:
>747_bases ATGGATTTCAGCGGTAAAAATGTCTGGGTAACCGGCGCGGGGAAAGGTATCGGCTACGCCACGGCGCTGGCGTTTGTTGA AGCGGGAGCGAAAGTTACAGGTTTTGATCAAGCGTTCGCTCAGGAGCAATATCCCTTTGCGACCGAAGTAATGGATGTTG CCGATGCTGCGCAGGTGGCGCAGGTATGTCAGCGACTGTTAGCTGAAACGGAGCGACTGGACGTGCTGGTCAATGCGGCG GGAATTTTGCGCATGGGCGCGACCGATCAGCTCAGTAAGGAGGACTGGCAGCAGACTTTTGCGGTTAATGTCGGCGGTGC GTTTAACCTGTTCCAGCAAACCATGAACCAGTTTCGCCGTCAGCGGGGCGGGGCGATTGTCACTGTGGCGTCCGACGCCG CACACACGCCGCGTATTGGTATGAGTGCTTATGGCGCATCGAAAGCGGCGCTGAAAAGCCTGGCGTTGAGCGTCGGGCTG GAACTGGCGGGTAGCGGCGTGCGCTGTAATGTGGTTTCGCCGGGTTCCACCGATACCGATATGCAACGCACGCTGTGGGT GAGCGATGACGCCGAAGAACAGCGTATTCGCGGCTTTGGCGAGCAGTTTAAACTCGGCATTCCGCTGGGGAAAATCGCCC GTCCACAAGAGATCGCCAACACGATTTTGTTCCTCGCCTCTGACCTCGCCAGCCATATCACCCTACAGGATATTGTGGTC GATGGCGGCTCAACGCTGGGGGCATAA
Upstream 100 bases:
>100_bases CGCGCTGGCGCAAAGTGCATGGCGATATCGACTTTGTCATGTTGGCGAAAAACCCGACCATCGACGCCTGGTGGAAGCTA CTCTCCCGCGAGGTGAAATA
Downstream 100 bases:
>100_bases GCATGATCTGGAAACGCCATTTAACGCTCGACGAACTGAACGCCACCAGCGATAACACAATGGTGGCGCATCTGGGAATT GTGTATACCCGTCTGGGCGA
Product: 2,3-dihydroxybenzoate-2,3-dehydrogenase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 248; Mature: 248
Protein sequence:
>248_residues MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFAQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDVLVNAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA
Sequences:
>Translated_248_residues MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFAQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDVLVNAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA >Mature_248_residues MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFAQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDVLVNAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA
Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=32.6693227091633, Blast_Score=108, Evalue=3e-24, Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=31.2741312741313, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=8e-20, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=29.8387096774194, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI40254992, Length=195, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=30.3501945525292, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=24.609375, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=31.7460317460317, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=24.609375, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=29.8387096774194, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI59889578, Length=232, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4503817, Length=236, Percent_Identity=25, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=99.1935483870968, Blast_Score=499, Evalue=1e-143, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=36.8, Blast_Score=131, Evalue=4e-32, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.7829457364341, Blast_Score=117, Evalue=6e-28, Organism=Escherichia coli, GI1788459, Length=197, Percent_Identity=31.9796954314721, Blast_Score=95, Evalue=6e-21, Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=25.4980079681275, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=27.2, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=32, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=28.4090909090909, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=27.9693486590038, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=27.8625954198473, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=29.5546558704453, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1787820, Length=176, Percent_Identity=30.6818181818182, Blast_Score=74, Evalue=1e-14, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32.8, Blast_Score=114, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=34.7169811320755, Blast_Score=113, Evalue=8e-26, Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=34.9624060150376, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=34.4827586206897, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=35.1145038167939, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=32.4427480916031, Blast_Score=105, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=35.2059925093633, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=34.2205323193916, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=33.2075471698113, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=28.8389513108614, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=32.5757575757576, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=31.8181818181818, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=27.734375, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.6992481203008, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=29.7959183673469, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30.8, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=29.811320754717, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=29.8804780876494, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=30.1587301587302, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17508651, Length=194, Percent_Identity=30.4123711340206, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=29.7397769516729, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=30.3703703703704, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI212645366, Length=245, Percent_Identity=31.8367346938775, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=30.6818181818182, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17538182, Length=230, Percent_Identity=30, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=28.1368821292776, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=29.6153846153846, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193207185, Length=148, Percent_Identity=36.4864864864865, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17568967, Length=205, Percent_Identity=30.2439024390244, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=28.8659793814433, Blast_Score=70, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17561272, Length=201, Percent_Identity=25.8706467661692, Blast_Score=68, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=219, Percent_Identity=29.2237442922374, Blast_Score=74, Evalue=2e-14, Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=6e-14, Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=27.7486910994764, Blast_Score=68, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=22.65625, Blast_Score=65, Evalue=9e-12, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=33.4645669291339, Blast_Score=107, Evalue=9e-24, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=33.6, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=32.9365079365079, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=32.4110671936759, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=32.4110671936759, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=32.1285140562249, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=29.0196078431373, Blast_Score=93, Evalue=1e-19, Organism=Drosophila melanogaster, GI24644337, Length=260, Percent_Identity=33.0769230769231, Blast_Score=91, Evalue=7e-19, Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI221331218, Length=216, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24665243, Length=216, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24665247, Length=217, Percent_Identity=28.110599078341, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI221331216, Length=217, Percent_Identity=28.110599078341, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI17737361, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR003560 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.28 [H]
Molecular weight: Translated: 26248; Mature: 26248
Theoretical pI: Translated: 4.74; Mature: 4.74
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFAQEQYPFATEVMDVADAAQVA CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH QVCQRLLAETERLDVLVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR HHHHHHHHHHHHHHHHEECHHHEEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH QRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD HHCCEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV HHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCHHHEEE DGGSTLGA ECCCCCCC >Mature Secondary Structure MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFAQEQYPFATEVMDVADAAQVA CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH QVCQRLLAETERLDVLVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR HHHHHHHHHHHHHHHHEECHHHEEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH QRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD HHCCEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV HHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCHHHEEE DGGSTLGA ECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2521622; 2521621; 9278503 [H]