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The map label for this gene is ypdF [H]

Identifier: 209397138

GI number: 209397138

Start: 3337797

End: 3338882

Strand: Reverse

Name: ypdF [H]

Synonym: ECH74115_3617

Alternate gene names: 209397138

Gene position: 3338882-3337797 (Counterclockwise)

Preceding gene: 209396535

Following gene: 209395774

Centisome position: 59.92

GC content: 57.09

Gene sequence:

>1086_bases
ATGACATTACTCGCTTCGCTGCGCGACTGGCTTAAGGCGCAACAACTGGATGCGGTGCTTCTCTCCTCACGGCAGAACAA
ACAGCCGCATCTGGGGATCTCCACCGGATCAGGCTATGTGCTGATTAGCCGTGAAAGTGCGCACATTCTGGTGGACTCGC
GCTATTACGCGGATGTAGAAGCCCGCACGCAAGGTTACCAGCTGCATTTGCTTGACGCGACGCACACGCTTACAACCATC
GCCAGGCAAATCATTGCCGATGAGCAGTTGCAAACGCTCGGTTTTGAAGGCCAGCAGGTGAGTTGGGAAACCGCGCATCG
CTGGCAGTCTGAACTCAATGCGAAACTGGTTAGCGCCACGCCGGATGTGCTGCGGCAAATCAAAACGCCAGAGGAGGTGG
AGAAAATCCGCCTTGCCTGTGGGATTGCCGATCGCGGTGCAGAGCATATTCGCCGCTTTATTCAGGCGGGGATGAGCGAG
CGCGAGATAGCCGCTGAACTGGAGTGGTTTATGCGCCAGCAGGGCGCAGAAAAAACCTCTTTTGACACCATTGTCGCCAG
TGGCTGGCGTGGGGCGCTGCCGCACGGCAAAGCCAGCGACAAGATTGTTGCAGCGGGCGAGTTTGTCACTCTCGATTTCG
GTGCGCTCTATCAGGGCTACTGCTCTGATATGACGCGCACCTTGCTGGTGAATGGCGAAGGGGTGAGCGCCGAATCTCAC
CCGCTGTTTAACGTCTATCAGATTGTTTTGCAGGCACAGCTCGCAGCAATCTCTGCAATTCGCCCCGGCGTGCGCTGCCA
GCAGGTTGACGAAGCCGCGCGTCGGGTGATTACCGAGGCAGGTTTTAGCCACTATTTCGGTCATAACACCGCTCATGCTA
TCGGCATTGAAGTTCATGAAGATCCGCGTTTTTCACCGCGGGACACCACGACGCTACAGCCAGGCATGTTACTGACCGTG
GAGCCGGGGATTTATTTGCCAGGGCAAGGGGGCGTGCGCATCGAGGATGTTGTGCTGGTCACCCCGCAAGGCGCAGAAGT
GCTCTACGCCATGCCGAAAACAGTGTTGCTCACGGGAGAGGCATAA

Upstream 100 bases:

>100_bases
TGGGGGCAGTCATAACTGCGCTGATGGTGGTGTTCCTGCGTCTGATGATGTTCCGTAAAGGCAAATTGTTAATCGATAGC
CTGTAAGAAGGAAAATCCAG

Downstream 100 bases:

>100_bases
TGGATTTATCGCTATTGAAAGCGTTGAGCGAGGCAGATGCGATCGCCTCCTCGGAACAGGAAGTGCGGCAGATCCTGCTG
GAAGAAGCGGATCGCCTGCA

Product: aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVEARTQGYQLHLLDATHTLTTI
ARQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
REIAAELEWFMRQQGAEKTSFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTAHAIGIEVHEDPRFSPRDTTTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Sequences:

>Translated_361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVEARTQGYQLHLLDATHTLTTI
ARQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
REIAAELEWFMRQQGAEKTSFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTAHAIGIEVHEDPRFSPRDTTTLQPGMLLTV
EPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA
>Mature_360_residues
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVEARTQGYQLHLLDATHTLTTIA
RQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSER
EIAAELEWFMRQQGAEKTSFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHP
LFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTAHAIGIEVHEDPRFSPRDTTTLQPGMLLTVE
PGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=254, Percent_Identity=29.9212598425197, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI149589008, Length=308, Percent_Identity=26.9480519480519, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=26.9480519480519, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI260593663, Length=243, Percent_Identity=28.3950617283951, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI264681563, Length=198, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI93141226, Length=174, Percent_Identity=34.4827586206897, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI264681565, Length=195, Percent_Identity=30.2564102564103, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788728, Length=361, Percent_Identity=96.1218836565097, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=254, Percent_Identity=29.9212598425197, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786364, Length=210, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=25.3333333333333, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=312, Percent_Identity=27.2435897435897, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71989583, Length=250, Percent_Identity=25.6, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509539, Length=190, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321118, Length=285, Percent_Identity=27.3684210526316, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320922, Length=244, Percent_Identity=25, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920384, Length=260, Percent_Identity=28.0769230769231, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357079, Length=294, Percent_Identity=27.5510204081633, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137632, Length=172, Percent_Identity=33.1395348837209, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39742; Mature: 39610

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECCH
ARTQGYQLHLLDATHTLTTIARQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
HCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKTS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
FDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCC
PLFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTAHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEEEC
DPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C
>Mature Secondary Structure 
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVLISRESAHILVDSRYYADVE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECCH
ARTQGYQLHLLDATHTLTTIARQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
HCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKTS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
FDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCC
PLFNVYQIVLQAQLAAISAIRPGVRCQQVDEAARRVITEAGFSHYFGHNTAHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEEEC
DPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]