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The map label for this gene is kdsD

Identifier: 209396758

GI number: 209396758

Start: 4185386

End: 4186372

Strand: Direct

Name: kdsD

Synonym: ECH74115_4519

Alternate gene names: 209396758

Gene position: 4185386-4186372 (Clockwise)

Preceding gene: 209398366

Following gene: 209397194

Centisome position: 75.11

GC content: 52.18

Gene sequence:

>987_bases
ATGTCGCACGTAGAGTTACAACCGGGTTTTGACTTTCAGCAAGCAGGTAAAGAAGTCCTGGCGATTGAACGTGAATGCCT
GGCGGAGCTTGATCAATACATCAATCAGAATTTCACGCTTGCCTGTGAAAAGATGTTCTGGTGTAAAGGGAAAGTTGTCG
TCATGGGGATGGGGAAATCGGGGCACATCGGGCGCAAAATGGCCGCAACGTTTGCCAGCACCGGTACACCTTCATTTTTC
GTCCATCCTGGTGAAGCCGCGCATGGTGATTTAGGCATGGTCACCCCACAGGATGTGGTGATTGCTATCTCTAACTCAGG
TGAATCCAGCGAAATCACTGCCTTAATTCCAGTGCTTAAGCGTCTTCACATACCGTTAATCTGCATCACCGGTCGCCCGG
AGAGCAGCATGGCGCGCGCCGCAGATGTGCATCTGTGTGTTAAAGTAGCGAAAGAAGCCTGTCCGTTAGGGCTGGCACCG
ACCAGCAGCACCACCGCCACGCTGGTTATGGGCGATGCCCTCGCTGTCGCGCTGTTAAAAGCACGCGGCTTTACTGCTGA
AGATTTTGCGCTCTCACACCCAGGCGGCGCACTGGGTCGTAAACTTCTGCTGCGCGTAAACGATATTATGCATACGGGCG
ATGAGATCCCGCATGTTAAGAAAACGGCCAGTCTGCGTGACGCATTGCTGGAAGTTACCCGCAAAAATCTTGGTATGACT
GTCATTTGCGATGACAATATGATGATTGAAGGCATCTTTACCGACGGTGATTTACGCCGTGTCTTCGATATGGGCGTGGA
TGTTCGTCAGTTAAGTATTGCCGATGTGATGACGCCGGGGGGAATACGCGTGCGCCCTGGCATTCTGGCCGTTGAGGCAC
TGAACTTAATGCAGTCCCGCCATATCACCTCCGTGATGGTTGCCGATGGCGACCATTTACTCGGTGTGTTACATATGCAT
GATTTACTGCGTGCAGGCGTAGTGTAA

Upstream 100 bases:

>100_bases
GGCCGTGGTGTAGGGGTATTATTAACTGGCGGATTTATCGTATGGCTGGCGATGTTGTACTGGTTATCGCCAATACTCGT
TGAATAACTGGAAACGCATT

Downstream 100 bases:

>100_bases
AGATTCAAGGATAAACAACAATGAGCAAAGCAGGTGCGTCGCTTGCGACCTGTTACGGCCCTGTCAGCGCCGACGTTATA
GCAAAAGCAGAGAACATTCG

Product: D-arabinose 5-phosphate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKSGHIGRKMAATFASTGTPSFF
VHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLKRLHIPLICITGRPESSMARAADVHLCVKVAKEACPLGLAP
TSSTTATLVMGDALAVALLKARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMT
VICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSRHITSVMVADGDHLLGVLHMH
DLLRAGVV

Sequences:

>Translated_328_residues
MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKSGHIGRKMAATFASTGTPSFF
VHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLKRLHIPLICITGRPESSMARAADVHLCVKVAKEACPLGLAP
TSSTTATLVMGDALAVALLKARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMT
VICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSRHITSVMVADGDHLLGVLHMH
DLLRAGVV
>Mature_327_residues
SHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKSGHIGRKMAATFASTGTPSFFV
HPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLKRLHIPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPT
SSTTATLVMGDALAVALLKARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMTV
ICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSRHITSVMVADGDHLLGVLHMHD
LLRAGVV

Specific function: Catalyzes the interconversion of D-arabinose 5-phosphate and D-ribulose 5-phosphate

COG id: COG0794

COG function: function code M; Predicted sugar phosphate isomerase involved in capsule formation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789588, Length=328, Percent_Identity=99.6951219512195, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI87082151, Length=316, Percent_Identity=45.8860759493671, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSD_ECO57 (Q8X9J0)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D91138
- PIR:   G85983
- RefSeq:   NP_289771.1
- RefSeq:   NP_312103.1
- ProteinModelPortal:   Q8X9J0
- SMR:   Q8X9J0
- EnsemblBacteria:   EBESCT00000027718
- EnsemblBacteria:   EBESCT00000057448
- GeneID:   916080
- GeneID:   961401
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4560
- KEGG:   ecs:ECs4076
- GeneTree:   EBGT00050000009485
- HOGENOM:   HBG754974
- OMA:   MLAMGDA
- ProtClustDB:   PRK10892
- BioCyc:   ECOL83334:ECS4076-MONOMER
- InterPro:   IPR000644
- InterPro:   IPR004800
- InterPro:   IPR001347
- SMART:   SM00116
- TIGRFAMs:   TIGR00393

Pfam domain/function: PF00571 CBS; PF01380 SIS

EC number: =5.3.1.13

Molecular weight: Translated: 35211; Mature: 35079

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS51371 CBS; PS51464 SIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKS
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEEEECCCC
GHIGRKMAATFASTGTPSFFVHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLK
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
RLHIPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPTSSTTATLVMGDALAVALLK
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHH
ARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMT
HCCCCCHHCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEE
VICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSR
EEECCCEEEEEEECCCHHHHHHHCCCCCEEEEHHHHCCCCCEEECCCCHHHHHHHHHHHC
HITSVMVADGDHLLGVLHMHDLLRAGVV
CCEEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKS
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEEEECCCC
GHIGRKMAATFASTGTPSFFVHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLK
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
RLHIPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPTSSTTATLVMGDALAVALLK
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHH
ARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMT
HCCCCCHHCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEE
VICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSR
EEECCCEEEEEEECCCHHHHHHHCCCCCEEEEHHHHCCCCCEEECCCCHHHHHHHHHHHC
HITSVMVADGDHLLGVLHMHDLLRAGVV
CCEEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796