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The map label for this gene is adrA [H]

Identifier: 209396741

GI number: 209396741

Start: 467067

End: 468182

Strand: Direct

Name: adrA [H]

Synonym: ECH74115_0459

Alternate gene names: 209396741

Gene position: 467067-468182 (Clockwise)

Preceding gene: 209397649

Following gene: 209395936

Centisome position: 8.38

GC content: 53.85

Gene sequence:

>1116_bases
ATGTTCCCAAAAATAATGAATGATGAAAACTTTTTCAAAAAAGCGGCGGCGCACGGGGAGGAACCTCCTTTAACTCCTCA
AAACGAACATCAGCGGTCCGGGCTGCGCTTCGCCCGTCGCGTCAGACTACCCCGTGCGGTTGGCCTGGCTGGCATGTTCT
TACCGATTGCTTCAACGCTGGTTTCACACCCGCCGCCGGGCTGGTGGTGGCTGGTGTTGGTCGGCTGGGCGTTCGTCTGG
CCGCATTTAGCCTGGCAGATAGCGAGCAGGGCCGTCGATCCGCTTAGCCGGGAAATTTACAACTTAAAAACCGATGCAGT
ATTAGCGGGAATGTGGGTAGGCGTAATGGGCGTAAACGTGCTGCCTTCCACCGCGATGTTGATGATTATGTGTCTGAATT
TGATGGGGGCAGGCGGCCCCCGTCTGTTTGTCGCGGGTCTGGTGTTGATGGTGGTTTCCTGCCTTGTCACCCTCGAGCTG
ACGGGCATTACCGTGTCGTTCAATAGTGCGCCGCTGGAATGGTGGCTCTCCCTTCCCATTATTGTCATTTATCCTCTGCT
GTTTGGCTGGGTCAGCTACCAGACGGCAACCAAACTGGCGGAACATAAACGCAGGTTGCAGGTCATGAGTACCCGCGACG
GCATGACGGGCGTGTATAACCGACGTCATTGGGAAACTATGTTACGCAATGAATTTGATAACTGTCGGCGGCATAATCGC
GATGCAACGTTACTGATTATCGATATCGACCATTTCAAGAGCATCAACGATACCTGGGGCCATGATGTGGGCGATGAAGC
GATTGTGGCGCTTACCCGACAGTTACAAATTACCCTGCGCGGTAGCGATGTGATTGGTCGGTTTGGCGGCGATGAGTTTG
CGGTAATCATGTCCGGTACGCCAGCTGAGAGCGCCATTACCGCCATGTTACGGGTGCATGAAGGGCTAAATACATTACGT
TTGCCGAATACGCCACAGGTAAATTTACGGATTAGTGTGGGGGTTGCGCCGCTGAACCCACAAATGAGTCACTATCGCGA
GTGGTTGAAATCGGCAGATTTGGCGCTCTACAAAGCAAAGAAAGCCGGACGTAACCGCACCGAAGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
ACCTGATAGTGCTAACGGGTGAGCTACTAAAATGGCTCACCCGAAATTTCATACTTCTGCCTTTAGCCCCGTCTCTATAA
TTTGGGAAAATTGTTTCTGA

Downstream 100 bases:

>100_bases
CGTCCGGCGAAAGTCATCAGGATTTGCTGAGTTTTTCTGATTTTTCCATACACTTCGTCATCGCTTCGATCACTGCGGCA
CGGAAGCCTTTCTCTTCCAG

Product: diguanylate cyclase AdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLR
LPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA

Sequences:

>Translated_371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLR
LPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>Mature_371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLR
LPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1786584, Length=371, Percent_Identity=99.7304582210243, Blast_Score=759, Evalue=0.0,
Organism=Escherichia coli, GI145693134, Length=159, Percent_Identity=34.5911949685535, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87081881, Length=171, Percent_Identity=34.5029239766082, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787262, Length=162, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87082007, Length=164, Percent_Identity=35.3658536585366, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788381, Length=177, Percent_Identity=29.9435028248588, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787802, Length=201, Percent_Identity=28.3582089552239, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787541, Length=179, Percent_Identity=31.8435754189944, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87081977, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787816, Length=165, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081974, Length=155, Percent_Identity=29.6774193548387, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788085, Length=180, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787056, Length=148, Percent_Identity=37.8378378378378, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788956, Length=150, Percent_Identity=29.3333333333333, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 41551; Mature: 41551

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
CCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHH
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
CCEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCEEECCCCCEEEEEEECC
PAESAITAMLRVHEGLNTLRLPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAK
CHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
KAGRNRTEVAA
HCCCCCCCCCC
>Mature Secondary Structure
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
CCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHH
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
CCEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCEEECCCCCEEEEEEECC
PAESAITAMLRVHEGLNTLRLPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAK
CHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
KAGRNRTEVAA
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]