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The map label for this gene is frlA

Identifier: 209396621

GI number: 209396621

Start: 4322905

End: 4324242

Strand: Direct

Name: frlA

Synonym: ECH74115_4682

Alternate gene names: 209396621

Gene position: 4322905-4324242 (Clockwise)

Preceding gene: 209396426

Following gene: 209396714

Centisome position: 77.58

GC content: 54.93

Gene sequence:

>1338_bases
ATGGGAAGCCAGGAACTCCAACGCAAGCTCGGATTTTGGGCCGTTCTTGCAATCGCCGTCGGGACAACCGTCGGCTCCGG
TATTTTTGTATCTGTGGGTGAAGTGGCAAAAGCGGCGGGCACGCCGTGGCTGACGGTGCTCGCATTTGTCATCGGCGGGT
TAATTGTGATCCCGCAAATGTGCGTATATGCGGAACTATCCACCGCTTATCCGGAAAATGGCGCAGATTATGTTTATCTG
AAAAATGCCGGAAGCCGACCGCTGGCTTTCCTCTCCGGCTGGGCCAGCTTCTGGGCCAACGATGCGCCGTCATTGTCGAT
TATGGCGCTGGCGATTGTCAGCAATCTTGGCTTTTTAACGCCTATCGATCCGTTGCTCGGTAAATTTATCGCCGCCGGAT
TAATTATCGCCTTTATGCTGCTGCACCTGCGCTCCGTTGAAGGCGGCGCAGCGTTTCAGACGCTAATTACCATCGCCAAA
ATTATCCCGTTCACTATCGTCATTGGTCTTGGGATCTTCTGGTTTAAAGCGGAGAATTTTGCCGCCCCTGCTACCACTGC
GATTGGCGCAACGGGCAGCTTTATGGCGCTGCTGGCGGGGATCTCTGCCACCAGTTGGTCGTATACCGGCATGGCCTCTA
TCTGTTATATGACCGGCGAAATTAAAAACCCCGGCAAAACCATGCCACGAGCGCTGATTGGTTCCTGTCTGCTGGTTCTG
GTGCTCTACACCCTGCTGGCGCTGGTGATTTCCGGCCTGATGCCCTTCGACAAACTCGCCAATTCTGAAACGCCGATTTC
CGACGCCCTGACCTGGATCCCCGCACTCGGCAGCACCGCTGGGATCTTTGTTGCCATCACGGCGATGATCGTCATTCTTG
GTTCGCTTTCCAGCTGCGTGATGTACCAGCCGCGGCTGGAATACGCGATGGCGAAAGACAACCTGTTCTTCAAATGCTTC
GGCCATGTGCATCCGAAATACAACACGCCGGATGTCTCCATCATTTTGCAAGGGGCGCTGGGGATCTTCTTCATCTTCGT
TTCCGATCTCACCAGCCTGCTGGGCTATTTCACCCTGGTAATGTGTTTCAAAAATACCCTCACCTTCGGCTCCATCATCT
GGTGTCGTAAACGCGACGATTACAAACCGCTGTGGCGTACTCCGGCTTTCGGGCTGATGACCCCCCTCGCCATTGCGTCA
AGCCTCATTCTGGTCGCCTCAACCTTTGTCTGGGCACCGATTCCCGGCCTTATCTGCGCCGTCATCGTTATTGCCACTGG
TCTGCCTGCTTACGCCTTCTGGGCGAAGCGTAGCCGCCAGCTCAACGCTTTGTCGTAA

Upstream 100 bases:

>100_bases
AACATCATATGTTGTTATATTCATCATGCATTGTCATGTCACCTTTTAAATGACTGCAAACTCTCCCCTACAACGTGTTG
GACAAGAAAAAGGTATCGCT

Downstream 100 bases:

>100_bases
TGTTATCTGGAGAAAATAAAATGTTGGATATTGATAAAAGCACTGTGGACTTTCTGGTCACCGAAAATATGGTTCAGGAA
GTGGAAAAAGTTCTCAGCCA

Product: putative fructoselysine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYAELSTAYPENGADYVYL
KNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAK
IIPFTIVIGLGIFWFKAENFAAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKTMPRALIGSCLLVL
VLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCF
GHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTPLAIAS
SLILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS

Sequences:

>Translated_445_residues
MGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYAELSTAYPENGADYVYL
KNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAK
IIPFTIVIGLGIFWFKAENFAAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKTMPRALIGSCLLVL
VLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCF
GHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTPLAIAS
SLILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS
>Mature_444_residues
GSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQMCVYAELSTAYPENGADYVYLK
NAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLTPIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKI
IPFTIVIGLGIFWFKAENFAAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKTMPRALIGSCLLVLV
LYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCVMYQPRLEYAMAKDNLFFKCFG
HVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLVMCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTPLAIASS
LILVASTFVWAPIPGLICAVIVIATGLPAYAFWAKRSRQLNALS

Specific function: May be involved in fructoselysine transport

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI187423910, Length=426, Percent_Identity=26.9953051643192, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7657591, Length=426, Percent_Identity=26.9953051643192, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71979932, Length=464, Percent_Identity=26.5086206896552, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI186910308, Length=439, Percent_Identity=21.8678815489749, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI186910306, Length=439, Percent_Identity=21.8678815489749, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI186910304, Length=439, Percent_Identity=21.8678815489749, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI115648063, Length=390, Percent_Identity=22.3076923076923, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI115648022, Length=390, Percent_Identity=22.3076923076923, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI33286428, Length=461, Percent_Identity=23.8611713665944, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI110347453, Length=352, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7657683, Length=398, Percent_Identity=25.6281407035176, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI181337167, Length=354, Percent_Identity=24.2937853107345, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4507047, Length=166, Percent_Identity=27.710843373494, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI9790235, Length=457, Percent_Identity=22.5382932166302, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI258614005, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258614003, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI114326544, Length=192, Percent_Identity=23.4375, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI114326550, Length=192, Percent_Identity=23.4375, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082250, Length=445, Percent_Identity=99.5505617977528, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=349, Percent_Identity=29.2263610315186, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082023, Length=332, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081708, Length=350, Percent_Identity=24, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788480, Length=272, Percent_Identity=27.2058823529412, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790575, Length=324, Percent_Identity=27.1604938271605, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081869, Length=422, Percent_Identity=22.7488151658768, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994972, Length=324, Percent_Identity=27.7777777777778, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=389, Percent_Identity=27.5064267352185, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71995382, Length=389, Percent_Identity=27.5064267352185, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71993915, Length=388, Percent_Identity=24.7422680412371, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982612, Length=418, Percent_Identity=24.8803827751196, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71982608, Length=418, Percent_Identity=24.8803827751196, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71990446, Length=426, Percent_Identity=24.6478873239437, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566699, Length=341, Percent_Identity=23.4604105571848, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532491, Length=404, Percent_Identity=22.7722772277228, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540018, Length=396, Percent_Identity=25.7575757575758, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI193208714, Length=391, Percent_Identity=23.7851662404092, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32566695, Length=391, Percent_Identity=23.7851662404092, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982623, Length=272, Percent_Identity=24.6323529411765, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=402, Percent_Identity=23.3830845771144, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=399, Percent_Identity=23.0576441102757, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17568033, Length=347, Percent_Identity=25.3602305475504, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321492, Length=353, Percent_Identity=24.6458923512748, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667468, Length=409, Percent_Identity=25.9168704156479, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357367, Length=399, Percent_Identity=26.5664160401003, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24641995, Length=366, Percent_Identity=26.2295081967213, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24641993, Length=366, Percent_Identity=26.2295081967213, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24651635, Length=360, Percent_Identity=24.7222222222222, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24651633, Length=360, Percent_Identity=24.7222222222222, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221331183, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17647653, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24664379, Length=404, Percent_Identity=25, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI221512776, Length=432, Percent_Identity=23.3796296296296, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24666159, Length=432, Percent_Identity=23.3796296296296, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45550968, Length=451, Percent_Identity=26.1640798226164, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921172, Length=451, Percent_Identity=26.1640798226164, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281366235, Length=353, Percent_Identity=25.4957507082153, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI116007820, Length=353, Percent_Identity=25.4957507082153, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24668806, Length=404, Percent_Identity=23.019801980198, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356285, Length=404, Percent_Identity=23.019801980198, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24668802, Length=404, Percent_Identity=23.019801980198, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI116007818, Length=355, Percent_Identity=25.6338028169014, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI85725152, Length=355, Percent_Identity=25.6338028169014, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI161077963, Length=364, Percent_Identity=22.8021978021978, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRLA_ECO57 (Q8X845)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B86002
- PIR:   E91156
- RefSeq:   NP_289918.1
- RefSeq:   NP_312248.1
- ProteinModelPortal:   Q8X845
- EnsemblBacteria:   EBESCT00000028601
- EnsemblBacteria:   EBESCT00000057779
- GeneID:   915924
- GeneID:   961536
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4731
- KEGG:   ecs:ECs4221
- GeneTree:   EBGT00050000009005
- HOGENOM:   HBG467352
- OMA:   SISHADQ
- ProtClustDB:   PRK11357
- BioCyc:   ECOL83334:ECS4221-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 47543; Mature: 47412

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1219c4d4)-; HASH(0x1222c360)-; HASH(0x11a7b530)-; HASH(0x12144bb4)-; HASH(0xeca0aa8)-; HASH(0x12168ad4)-; HASH(0x11863770)-; HASH(0x11468f94)-; HASH(0x12029b24)-; HASH(0x10fd7f08)-; HASH(0x11ca9cb0)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQM
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
CVYAELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLT
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
PIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKIIPFTIVIGLGIFWFKAENF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
AAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKTMPRALIGSCLLVL
CCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHH
VLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCV
HHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLV
EECCHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTPLAIASSLILVASTFVWAPIPGLICA
HHHHHHCCHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VIVIATGLPAYAFWAKRSRQLNALS
HHHHHCCCHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
GSQELQRKLGFWAVLAIAVGTTVGSGIFVSVGEVAKAAGTPWLTVLAFVIGGLIVIPQM
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
CVYAELSTAYPENGADYVYLKNAGSRPLAFLSGWASFWANDAPSLSIMALAIVSNLGFLT
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
PIDPLLGKFIAAGLIIAFMLLHLRSVEGGAAFQTLITIAKIIPFTIVIGLGIFWFKAENF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
AAPATTAIGATGSFMALLAGISATSWSYTGMASICYMTGEIKNPGKTMPRALIGSCLLVL
CCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHH
VLYTLLALVISGLMPFDKLANSETPISDALTWIPALGSTAGIFVAITAMIVILGSLSSCV
HHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MYQPRLEYAMAKDNLFFKCFGHVHPKYNTPDVSIILQGALGIFFIFVSDLTSLLGYFTLV
EECCHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MCFKNTLTFGSIIWCRKRDDYKPLWRTPAFGLMTPLAIASSLILVASTFVWAPIPGLICA
HHHHHHCCHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VIVIATGLPAYAFWAKRSRQLNALS
HHHHHCCCHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796