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The map label for this gene is mppA [H]

Identifier: 209396617

GI number: 209396617

Start: 1869600

End: 1871213

Strand: Direct

Name: mppA [H]

Synonym: ECH74115_1977

Alternate gene names: 209396617

Gene position: 1869600-1871213 (Clockwise)

Preceding gene: 209400888

Following gene: 209397767

Centisome position: 33.55

GC content: 48.2

Gene sequence:

>1614_bases
ATGAAGCACTCTGTTTCAGTCACGTGTTGTGCGCTGTTGGTCAGCAGCATTTCTCTTTCGTATGCTGCAGAAGTTCCGAG
CGGCACAGTACTGGCAGAGAAGCAGGAGCTGGTGCGCCACATTAAAGATGAGCCTGCGTCGCTGGATCCCGCTAAAGCCG
TGGGCCTGCCAGAGATTCAGGTCATTCGCGATCTGTTTGAAGGACTGGTGAATCAGAACGAGAAAGGGGAGATTGTCCCC
GGCGTTGCGACTCAGTGGAAAAGTAATGACAACCGTATCTGGACTTTTACCCTGCGCGATAACGCAAAATGGGCGGATGG
CACACCGGTAACGGCGCAAGATTTTGTCTGCAGCTGGCAGCGTCTGGTGGACCCGAAAACGCTATCGCCATTTGCATGGT
TTGCCGCGCTGGCGGGAATCAACAACGCACAGGCGATTATTGATGGTAAAGCTACACCTGACCAGCTTGGCGTCACCGCA
GTTGATGTCCATACTTTGAAAATTCAGCTTGATAAACCGTTGCCGTGGTTTGTGAATTTAACCGCTAACTTTGCCTTCTT
CCCGGTGCAAAAAGCCAACGTAGAAAGCGGTAAAGAGTGGACGAAACCCGGAAATCTGATCGGCAATGGCGCTTATGTTC
TTAAAGAGCGCGTAGTCAATGAAAAACTGGTCGTGGTACCGAATACCCATTATTGGGATAACGCCAAAACGGTACTGCAA
AAAGTGACCTTCCTGCCAATTAATCAGGAATCCGCAGCCACTAAGCGTTACCTCGCGGGGGATATTGATATCACCGAATC
CTTCCCGAAAAATATGTATCAGAAGCTGTTGAAGGATATTCCGGGGCAGGTTTATACGCCGCCGCAGCTCGGGACCTATT
ATTATGCGTTTAACACGCAAAAAGGGCCGACGGCAGATCAGCGCGTTCGTCTGGCATTAAGTATGACGATAGATCGCCGC
CTGATGACCGAAAAAGTATTAGGGACGGGCGAAAAGCCAGCGTGGCATTTTACACCAGATGTTACCGCCGGATTTACGCC
GGAACCTTCGCCGTTTGAACAAATGAGTCAGGAAGAACTGAATGCGCAGGCAAAAACTTTGTTGAGCGCAGCTGGTTATG
GTCCGCAAAAACCGCTGAAGCTGACGCTTTTGTATAACACTTCAGAAAACCATCAAAAAATTGCGATTGCTGTAGCATCG
ATGTGGAAAAAGAACCTTGGCGTAGATGTTAAATTGCAAAATCAGGAATGGAAAACCTATATCGATAGCCGTAACACCGG
CAATTTTGATGTTATCCGCGCCTCATGGGTGGGGGATTATAATGAACCCTCCACTTTCCTGACATTATTAACGTCAACGC
ATTCAGGAAATATTTCACGCTTTAACAATCCGGCATACGACAAAGTTCTGGCCCAGGCATCGACGGAAAATACCGTTAAA
GCGCGTAATGCCGATTACAACGCGGCAGAAAAAATCCTCATGGAGCAAGCACCGATTGCACCAATTTATCAATATACCAA
TGGACGATTAATCAAACCGTGGCTGAAAGGTTATCCCATTAATAACCCTGAGGATGTGGCGTACAGTCGGACTATGTATA
TTGTGAAGCATTGA

Upstream 100 bases:

>100_bases
TTATGCTTCCTGTGTCACTTTCTGATGGAAGTTGTTTGCATTTCTTTAAGGCGAAACAAATAATTACGCATCAATTTTAA
TGTCGGTTAGAGGGAAACTT

Downstream 100 bases:

>100_bases
TGTGATGGGAACTGGCGTTACCCTTGTGGATAACGCCAGTGATGTCTGATTTAGCGACCCTGTTCCGGCGGTGTAATGTT
ATCCATATACAGCGTCTGGC

Product: periplasmic murein peptide-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVCSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDVHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH

Sequences:

>Translated_537_residues
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVCSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDVHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
>Mature_537_residues
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVCSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDVHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH

Specific function: Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI87081878, Length=537, Percent_Identity=99.6275605214153, Blast_Score=1104, Evalue=0.0,
Organism=Escherichia coli, GI1787495, Length=531, Percent_Identity=48.0225988700565, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1789397, Length=529, Percent_Identity=42.34404536862, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787762, Length=538, Percent_Identity=28.2527881040892, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789887, Length=473, Percent_Identity=24.9471458773784, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1789966, Length=466, Percent_Identity=21.8884120171674, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787052, Length=503, Percent_Identity=20.8747514910537, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59869; Mature: 59869

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQ
CCCCCHHHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCHHH
VIRDLFEGLVNQNEKGEIVPGVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVCSWQ
HHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
RLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDVHTLKIQLDKPLPWFVNL
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEEEEEEEEECCCCCEEEEE
TANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
EECEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQ
HHHEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECC
KGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEEL
CCCCHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
NAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTY
HHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECCCCHHHH
IDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
CCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEE
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
ECCCCCHHHHHHHHHCCCCCCEEEECCCEEECHHHCCCCCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQ
CCCCCHHHHHHHHHHHHHHHEEECCCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCHHH
VIRDLFEGLVNQNEKGEIVPGVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVCSWQ
HHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
RLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDVHTLKIQLDKPLPWFVNL
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEEEEEEEEECCCCCEEEEE
TANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
EECEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQ
HHHEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECC
KGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEEL
CCCCHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
NAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTY
HHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECCCCHHHH
IDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
CCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEE
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
ECCCCCHHHHHHHHHCCCCCCEEEECCCEEECHHHCCCCCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495761; 9097039; 9278503 [H]