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The map label for this gene is sstT

Identifier: 209396321

GI number: 209396321

Start: 4082659

End: 4083903

Strand: Direct

Name: sstT

Synonym: ECH74115_4404

Alternate gene names: 209396321

Gene position: 4082659-4083903 (Clockwise)

Preceding gene: 209395978

Following gene: 209397929

Centisome position: 73.27

GC content: 54.94

Gene sequence:

>1245_bases
ATGACTACGCAACGTTCACCGGGGCTATTCCGGCGTCTGGCTCATGGCAGCCTGGTAAAACAAATCCTGGTCGGCCTTGT
TCTGGGGATTCTTCTGGCATGGATCTCAAAACCCGCGGCGGAAGCTGTTGGTCTGTTAGGTACTTTGTTCGTCGGCGCAC
TGAAAGCCGTTGCCCCCATCCTGGTGTTGATGCTGGTGATGGCATCTATTGCTAACCACCAGCACGGGCAGAAAACCAAT
ATCCGCCCTATTTTGTTCCTCTATCTGCTGGGTACCTTCTCTGCTGCTCTGGCCGCAGTCGTTTTCAGCTTCGCCTTCCC
TTCTACCCTGCACTTATCCAGTAGCGCGGGTGATATTTCGCCACCGTCAGGCATTGTAGAAGTGATGCGCGGGCTGGTAA
TGAGCATGGTTTCCAACCCCATCGACGCGCTGCTGAAAGGTAACTACATCGGGATCCTGGTGTGGGCAATTGGCCTCGGT
TTCGCACTGCGTCACGGTAACGAGACCACCAAAAACCTGGTCAACGATATGTCGAATGCCGTCACCTTTATGGTGAAACT
GGTCATTCGCTTCGCACCGATTGGTATTTTTGGTCTGGTTTCTTCTACCCTGGCAACCACCGGTTTCTCCACACTGTGGG
GCTACGCGCAACTGCTGGTCGTGCTGGTTGGCTGTATGTTACTGGTGGCGCTGGTGGTTAACCCATTGCTGGTGTGGTGG
AAAATTCGTCGTAACCCGTTCCCGCTGGTGCTGCTGTGCCTGCGCGAAAGCGGCGTGTATGCCTTCTTCACCCGCAGCTC
TGCGGCGAACATTCCGGTGAATATGGCACTGTGTGAAAAGCTGAATCTGGATCGCGATACCTATTCCGTTTCTATTCCGC
TGGGAGCCACCATCAATATGGCGGGCGCAGCAATCACCATTACCGTGTTGACGCTGGCTGCGGTTAATACGCTGGGTATT
CCGGTCGATCTGCCCACAGCGCTGCTGTTGAGCGTAGTGGCTTCTCTGTGTGCCTGTGGCGCATCCGGCGTGGCGGGGGG
TTCTTTGCTGCTGATCCCACTGGCCTGTAATATGTTCGGTATTTCGAACGATATCGCCATGCAGGTGGTTGCCGTCGGCT
TTATTATCGGCGTATTGCAGGACTCTTGCGAAACCGCGCTGAACTCTTCAACTGACGTGCTGTTCACTGCGGCAGCTTGC
CAGGCGGAAGACGATCGTCTGGCAAATAGCGCCCTGCGTAATTAA

Upstream 100 bases:

>100_bases
TTTCCTTATACTCGACCTTGCAAACACTTTGTTACATCCTGAAAGATGCGTCGACAGAACGCACCAGGGATGTGCGACAA
CACAATGAAAGGATCGAAAA

Downstream 100 bases:

>100_bases
TTGTTTAACCCCTTTCGTCTATGGCGGGAGGGGTTTTCTCTACTTTAAACGGATCAATTCCCCTTTTCTGCATCCGCCAG
AAACGAATGATATTCAGGCC

Product: serine/threonine transporter SstT

Products: NA

Alternate protein names: Na(+)/serine-threonine symporter

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTN
IRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLG
FALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWW
KIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGI
PVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAAC
QAEDDRLANSALRN

Sequences:

>Translated_414_residues
MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTN
IRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLG
FALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWW
KIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGI
PVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAAC
QAEDDRLANSALRN
>Mature_413_residues
TTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTNI
RPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGF
ALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWWK
IRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGIP
VDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQ
AEDDRLANSALRN

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)

COG id: COG3633

COG function: function code E; Na+/serine symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI4827012, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI21314632, Length=265, Percent_Identity=27.5471698113208, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI223468566, Length=273, Percent_Identity=27.1062271062271, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169790839, Length=244, Percent_Identity=23.3606557377049, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI5032093, Length=273, Percent_Identity=27.1062271062271, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI223468564, Length=266, Percent_Identity=27.8195488721804, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789473, Length=414, Percent_Identity=100, Blast_Score=819, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=353, Percent_Identity=24.0793201133144, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790514, Length=426, Percent_Identity=24.4131455399061, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=24.0566037735849, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71996953, Length=271, Percent_Identity=26.1992619926199, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983099, Length=275, Percent_Identity=25.0909090909091, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71983106, Length=275, Percent_Identity=25.0909090909091, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193206505, Length=267, Percent_Identity=27.7153558052434, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SSTT_ECO57 (P0AGE5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85970
- PIR:   C91125
- RefSeq:   NP_289663.1
- RefSeq:   NP_311998.1
- ProteinModelPortal:   P0AGE5
- SMR:   P0AGE5
- EnsemblBacteria:   EBESCT00000024117
- EnsemblBacteria:   EBESCT00000058927
- GeneID:   916190
- GeneID:   958142
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4442
- KEGG:   ecs:ECs3971
- GeneTree:   EBGT00050000009806
- HOGENOM:   HBG289387
- OMA:   THIRPIL
- ProtClustDB:   PRK13628
- BioCyc:   ECOL83334:ECS3971-MONOMER
- HAMAP:   MF_01582
- InterPro:   IPR001991
- InterPro:   IPR023025
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 43478; Mature: 43347

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x119bf09c)-; HASH(0xecf0a0c)-; HASH(0x11992590)-; HASH(0x1143e96c)-; HASH(0x114ff190)-; HASH(0x1192ddf8)-; HASH(0x1171bc54)-; HASH(0xecb5f30)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHCH
>Mature Secondary Structure 
TTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDIS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
PPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFALRHGNETTKNLVNDMSNA
CCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWW
HHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINM
HHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEC
AGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFG
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHC
ISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDDRLANSALRN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796