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The map label for this gene is aaeA [H]

Identifier: 209396247

GI number: 209396247

Start: 4225198

End: 4226127

Strand: Reverse

Name: aaeA [H]

Synonym: ECH74115_4558

Alternate gene names: 209396247

Gene position: 4226127-4225198 (Counterclockwise)

Preceding gene: 209399458

Following gene: 209400336

Centisome position: 75.84

GC content: 53.87

Gene sequence:

>930_bases
GTGAAAACACTAATAAGAAAATTCTCCCGTACGGCCATCACGGTCGTATTAGTCATTCTGGCCTTCATCGCAATTTTTAA
TGCCTGGGTCTATTACACCGAATCCCCCTGGACGCGTGACGCGCGCTTTAGCGCTGACGTCGTTGCGATCGCGCCGGACG
TTTCTGGACTCATTACCCAGGTGAATGTTCATAACCAGCTGGTGAAAAAAGGACAGGTTCTGTTCACCATCGACCAGCCG
CGCTATCAAAAGGCGCTTGAGGAAGCGCAAGCCGATGTTGCTTATTATCAGGTACTGGCACAGGAGAAACGCCAGGAGGC
CGGACGTCGTAACCGTCTCGGTGTGCAGGCGATGTCTCGCGAAGAGATCGACCAGGCCAACAACGTACTACAAACGGTTC
TGCATCAGTTAGCGAAAGCGCAGGCGACCCGCGATCTGGCAAAACTGGATCTTGAACGCACGGTGATCCGCGCGCCAGCA
GATGGCTGGGTGACCAACCTCAACGTCTATACCGGTGAGTTTATTACTCGTGGATCAACGGCGGTTGCGCTGGTGAAACA
GAACTCTTTCTATGTACTGGCCTATATGGAAGAAACTAAGCTGGAAGGGGTGCGCCCTGGGTATCGTGCAGAGATCACGC
CGCTTGGCAGTAACAAAGTGCTGAAAGGGACTGTTGATAGTGTTGCCGCTGGGGTCACCAACGCCAGCAGCACGCGTGAC
GACAAAGGGATGGCGACCATCGACTCTAACCTTGAATGGGTGCGTTTGGCGCAACGTGTTCCGGTTCGTATTCGTCTCGA
CAACCAGCAAGAGAACATCTGGCCTGCGGGCACCACTGCTACAGTGGTGGTCACTGGCAAACAAGATCGCGACGAAAGCC
AGGATTCGTTCTTCCGTAAAATGGCCCATCGCCTGCGTGAGTTTGGTTAA

Upstream 100 bases:

>100_bases
ACAGGTATCTACGACTTTGTCTGGCATCCGGCGTTGTTCAACACCGCGCTCTATTGCTGCTTGTTTTATTTGATATCGCG
ACTGTTCGTTTGAGGTTGAA

Downstream 100 bases:

>100_bases
TCACGATGGATATTTTCTCCATTGCTAACCAACATATTCGCTTTGCGGTAAAACTGGCGACCGCCATTGTACTGGCGCTG
TTTGTTGGCTTTCACTTCCA

Product: p-hydroxybenzoic acid efflux subunit AaeA

Products: NA

Alternate protein names: pHBA efflux pump protein A [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHNQLVKKGQVLFTIDQP
RYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPA
DGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRD
DKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG

Sequences:

>Translated_309_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHNQLVKKGQVLFTIDQP
RYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPA
DGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRD
DKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG
>Mature_309_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHNQLVKKGQVLFTIDQP
RYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPA
DGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRD
DKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=99.3548387096774, Blast_Score=626, Evalue=0.0,
Organism=Escherichia coli, GI87081951, Length=282, Percent_Identity=40.4255319148936, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1790519, Length=301, Percent_Identity=28.9036544850498, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788711, Length=310, Percent_Identity=25.4838709677419, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789041, Length=288, Percent_Identity=26.7361111111111, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022871
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 34646; Mature: 34646

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCCHHHEE
VNVHNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSR
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCEEECCCE
AVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRD
EEEEEECCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHCCCCCCCCCC
DKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRK
CCCCEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHH
MAHRLREFG
HHHHHHHCC
>Mature Secondary Structure
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCCHHHEE
VNVHNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSR
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCEEECCCE
AVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRD
EEEEEECCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHCCCCCCCCCC
DKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRK
CCCCEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHH
MAHRLREFG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA